Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Binyam Bezabeh"'
Autor:
R. James Christie, Arnaud C. Tiberghien, Qun Du, Binyam Bezabeh, Ryan Fleming, Amanda Shannon, Shenlan Mao, Shannon Breen, Jing Zhang, Haihong Zhong, Jay Harper, Herren Wu, Philip W. Howard, Changshou Gao
Publikováno v:
Antibodies, Vol 6, Iss 4, p 20 (2017)
Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by selecting stable conjugation positions or hydrolysis of the thiosuccinimide. Here, we investigate
Externí odkaz:
https://doaj.org/article/d8a3eda79f854774ad8483d0cf099f77
Autor:
Robert Hollingsworth, Emil Michelotti, Nazzareno Dimasi, Andrew Buchanan, Philip Martin, Maureen Kennedy, David Stewart, John Meekin, Binyam Bezabeh, Ryan Fleming, Kelly McGlinchey, Kathy Mulgrew, Patrick Strout, Cui Chen, Allison Marrero, Jon Chesebrough, Leslie Wetzel, Raymond Rothstein, Jay Harper, Jonathan Rios-Doria
Figure S1. Expression of tumor-associated antigens in mouse tumor cell lines; Table S1. Number of complete responses in CT26 tumor-bearing mice that were treated with EphA2-Tub or EphA2-PBD; Figure S2. Activity of EphA2-Tub and EphA2-PBD in the Renca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15729cf380a40b828f0636c11caf6ec
https://doi.org/10.1158/0008-5472.22413317
https://doi.org/10.1158/0008-5472.22413317
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Purpose: To use preclinical models to identify a dosing schedule that improves tolerability of highly potent pyrrolobenzodiazepine dimers (PBDs) antibody drug conjugates (ADCs) without compromising antitumor activity.Experimental Design: A series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bff01a2c0da935c0ea2819fe0a9ef9
https://doi.org/10.1158/1078-0432.c.6526344
https://doi.org/10.1158/1078-0432.c.6526344
Autor:
Rakesh Dixit, Nazzareno Dimasi, Phillip W. Howard, Arnaud Tiberghien, Luke Masterson, Cui Chen, Neki Patel, Shannon Breen, Patricia C. Ryan, Molly Reed, Marlon Rebelatto, Kapil Vashisht, Binyam Bezabeh, Jay Harper, Haihong Zhong, Michele Gunsior, Xiang Qing Yu, Shameen Afif-Rider, Bo Zheng, Pauline M. Ryan, Mary Jane Masson Hinrichs
Supplementary Figure 1. (a,b) Structure of the payloads SG3249 and SG3400; Supplementary Figure 2. PK concentration vs. time profile of R347-SG3400 in monkeys after either a single IV injection of 4.5mg/kg or 3 weekly IV injections of 1.5mg/kg; Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18262bd2056388988e5e07e301278edb
https://doi.org/10.1158/1078-0432.22466538
https://doi.org/10.1158/1078-0432.22466538
Autor:
Robert Hollingsworth, Emil Michelotti, Nazzareno Dimasi, Andrew Buchanan, Philip Martin, Maureen Kennedy, David Stewart, John Meekin, Binyam Bezabeh, Ryan Fleming, Kelly McGlinchey, Kathy Mulgrew, Patrick Strout, Cui Chen, Allison Marrero, Jon Chesebrough, Leslie Wetzel, Raymond Rothstein, Jay Harper, Jonathan Rios-Doria
Immunogenic cell death (ICD) is the process by which certain cytotoxic drugs induce apoptosis of tumor cells in a manner that stimulates the immune system. In this study, we investigated whether antibody–drug conjugates (ADCS) conjugated with pyrro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6170bbc937f404240a8439cdd3db8730
https://doi.org/10.1158/0008-5472.c.6508682.v1
https://doi.org/10.1158/0008-5472.c.6508682.v1
Autor:
Philip Howard, Cui Tracy Chen, Haihong Zhong, Nazzareno Dimasi, John Meekin, Paul Hynes, David A. Tice, Kenneth C. Anderson, Elaine M. Hurt, Xiaodong Xiao, Krista Kinneer, Reena Varkey, Yu-Tzu Tai, Ronald Herbst, Ryan Fleming, Shannon Breen, Suneetha Thomas, Binyam Bezabeh, Leslie Wetzel, Ruoyan Chen, Matt Flynn
Publikováno v:
Leukemia. 33:766-771
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6135659601af5645d71933863cdf90bd
https://doi.org/10.1038/s41375-018-0278-7
https://doi.org/10.1038/s41375-018-0278-7
Autor:
John Meekin, Haihong Zhong, Maureen Kennedy, Rosa A. Carrasco, Ronald Herbst, Sandrina Phipps, Binyam Bezabeh, R. James Christie, Karma Dacosta, David A. Tice, Emily E. Bosco, Jiping Zha, Rakesh Dixit, Partha S. Chowdhury, Joanne Ayriss, Qun Du, Zhan Xiao, Darrin Sabol, MaryJane Hinrichs, Cui Chen, Shannon Breen, Lee Brown, Molly Reed
Publikováno v:
Oncotarget
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. A greater understanding of the molecular characteristics of breast tumors could ultimately lead to improved tumor-targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ad154b2ef7e44c63da1dd1a359911a
https://doi.org/10.18632/oncotarget.25160
https://doi.org/10.18632/oncotarget.25160
Autor:
Saravanan Rajan, Binyam Bezabeh, Li Zhuang, Changshou Gao, Carl Hay, Erin Sult, Peter Cariuk, Michael A. Bowen, Ryan Fleming, Andrew Buchanan, Nazzareno Dimasi, Herren Wu, Kris Sachsenmeier, Jincheng Wu
Publikováno v:
mAbs. 9:438-454
We developed an IgG1 domain-tethering approach to guide the correct assembly of 2 light and 2 heavy chains, derived from 2 different antibodies, to form bispecific monovalent antibodies in IgG1 format. We show here that assembling 2 different light a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33def00fd0cb500796b2baf1e5a76c3
https://doi.org/10.1080/19420862.2016.1277301
https://doi.org/10.1080/19420862.2016.1277301
Autor:
Robert E. Hollingsworth, Adeela Kamal, Haihong Zhong, Ryan Fleming, Nazzareno Dimasi, Herren Wu, Mary Jane Hinrichs, Xiang-Qing Yu, Pamela Thompson, Robert M. Woods, Patrick Strout, Song Cho, Cui Chen, Molly Reed, Rakesh Dixit, Binyam Bezabeh, Fengying Huang, Jay Harper, Xizhe Gao, Shenlan Mao, Changshou Gao
Publikováno v:
Journal of Controlled Release. 236:100-116
Antibody-drug conjugates (ADCs) are among the most promising empowered biologics for cancer treatment. ADCs are commonly prepared by chemical conjugation of small molecule cytotoxic anti-cancer drugs to antibodies through either lysine side chains or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c2272903e2d1065a7e37d4befb96bc
https://doi.org/10.1016/j.jconrel.2016.06.025
https://doi.org/10.1016/j.jconrel.2016.06.025
Autor:
Binyam Bezabeh, DW Jenkins, Vanessa Muniz-Medina, Ryan Fleming, Herren Wu, Jy Li, Leslie Wetzel, Samuel R. Perry, Jane K. Osbourn, Nazzareno Dimasi, Changshou Gao, Steve Coats, Marlon Rebelatto
Publikováno v:
Cancer Research. 76:PD5-08
Current HER2-targeted drugs are ineffective in killing cancer cells expressing relatively low levels of HER2. Therefore, more than 60% of breast cancer patients are ineligible for HER2-targeted therapies because of lack of HER2 overexpression and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::baecdbe81f5fdc52473d2b3d1dbf6ee8
https://doi.org/10.1158/1538-7445.sabcs15-pd5-08
https://doi.org/10.1158/1538-7445.sabcs15-pd5-08