Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Binyam Belachew"'
Publikováno v:
Methods in Enzymology ISBN: 9780323914765
Methods Enzymol
Methods Enzymol
Helicases function in most biological processes that utilize nucleic acids including replication, recombination, repair, transcription, splicing, translation and other processes that involve RNA or DNA. They are motor proteins that bind ATP then cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11afdc486e665ac7c3a9ef6c435322ea
https://doi.org/10.1016/bs.mie.2022.03.066
https://doi.org/10.1016/bs.mie.2022.03.066
Publikováno v:
The Enzymes
RNA viruses cause many routine illnesses, such as the common cold and the flu. Recently, more deadly diseases have emerged from this family of viruses. The hepatitis C virus has had a devastating impact worldwide. Despite the cures developed in the U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a8ad6b2f4c7a2f804ca7991fd1a53edf
http://europepmc.org/articles/PMC8562938
http://europepmc.org/articles/PMC8562938
Publikováno v:
Journal of Biological Chemistry. 298:102486
Hepatitis C virus (HCV) is a major cause of liver-related diseases and hepatocellular carcinoma. The helicase domain of one of the nonstructural proteins of HCV, NS3 (nonstructural protein 3), is essential for viral replication; however, its specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd32adaa2d7f57a69519f3c769b1e205
https://doi.org/10.1016/j.jbc.2022.102486
https://doi.org/10.1016/j.jbc.2022.102486
Publikováno v:
Viral Replication Enzymes and their Inhibitors Part B ISBN: 9780323900164
RNA viruses cause many routine illnesses, such as the common cold and the flu. Recently, more deadly diseases have emerged from this family of viruses. The hepatitis C virus has had a devastating impact worldwide. Despite the cures developed in the U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27e4e0a8223a2684fd853a28bc37d92e
https://doi.org/10.1016/bs.enz.2021.09.005
https://doi.org/10.1016/bs.enz.2021.09.005
Autor:
Naresh Gunaganti, Yuet-Kin Leung, Lingtian Zhang, Naga Rajiv Lakkaniga, Brendan Frett, Hong-yu Li, Binyam Belachew
Publikováno v:
European journal of medicinal chemistry. 206
Gene fusions and point mutations of RET kinase are crucial for driving thoracic cancers, including thyroid cancer and non-small cell lung cancer. Various scaffolds based on different heterocycles have been synthesized and evaluated as RET inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af47f273515d3e807dabef02dea8cf97
https://pubmed.ncbi.nlm.nih.gov/32823007
https://pubmed.ncbi.nlm.nih.gov/32823007