Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Binuraj R. K. Menon"'
Autor:
Jonathan Latham, Jean-Marc Henry, Humera H. Sharif, Binuraj R. K. Menon, Sarah A. Shepherd, Michael F. Greaney, Jason Micklefield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with
Externí odkaz:
https://doaj.org/article/0433d1f6927342b4876e95b9f595c6da
Autor:
Binuraj R. K. Menon
Publikováno v:
Nature Chemistry. 13:101-106
Ingrained prejudices and a lack of action addressing discrimination are some of the main reasons why academic chemistry is overwhelmingly white. Data and discussions on racial inequalities are often greeted with scepticism and cynicism within the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c5e5f526bd7c69aec2c25eef4a3497
https://doi.org/10.1038/s41557-020-00632-8
https://doi.org/10.1038/s41557-020-00632-8
The development of enzymatic routes toward amide and carboxylic acid bond formation in bioactive molecular scaffolds using aqueous conditions is a major challenge for biopharmaceutical and fine chemical industrial sectors. We report biocatalytic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911cdb5e69053a8b09f763889e7dc79d
http://wrap.warwick.ac.uk/163508/1/WRAP-Versatile-and-facile-one-pot-biosynthesis-for-amides-and-carboxylic-acids-Menon-2022.pdf
http://wrap.warwick.ac.uk/163508/1/WRAP-Versatile-and-facile-one-pot-biosynthesis-for-amides-and-carboxylic-acids-Menon-2022.pdf
This paper explores the implications for international development policy and practice - specifically within the sectors of building security and justice after conflict - of the departure of those assuming caring roles, predominantly women who become
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb634da38d883970fb1db4c5b5daed1
http://wrap.warwick.ac.uk/142066/7/WRAP-halogenases-biosynthetic-pathway-engineering-Menon-2020.pdf
http://wrap.warwick.ac.uk/142066/7/WRAP-halogenases-biosynthetic-pathway-engineering-Menon-2020.pdf
Autor:
Binuraj R. K. Menon, Matthew Jenner
Publikováno v:
Nature Chemistry. 10:245-247
Rational engineering of biosynthetic assembly lines for production of new compounds is an attractive prospect, yet it presents many challenges. Learning from biology, some of the rules for expanding the chemical diversity of non-ribosomal peptides ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae886aa09999e5f3c22b6058fd0e3d8
https://doi.org/10.1038/nchem.2941
https://doi.org/10.1038/nchem.2941
Autor:
George F. S. Whitehead, Eriko Takano, Simon J. Webb, Binuraj R. K. Menon, Anna D. Peters, Jason Micklefield, Matthew Cummings
Publikováno v:
PLoS Biology
Cummings, M, Peters, A, Whitehead, G, Menon, B, Micklefield, J, Webb, S & Takano, E 2019, ' Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli ', PL o S Biology . https://doi.org/10.1371/journal.pbio.3000347
PLoS Biology, Vol 17, Iss 7, p e3000347 (2019)
Cummings, M, Peters, A, Whitehead, G, Menon, B, Micklefield, J, Webb, S & Takano, E 2019, ' Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli ', PL o S Biology . https://doi.org/10.1371/journal.pbio.3000347
PLoS Biology, Vol 17, Iss 7, p e3000347 (2019)
Polyketides are a class of specialised metabolites synthesised by both eukaryotes and prokaryotes. These chemically and structurally diverse molecules are heavily used in the clinic and include frontline antimicrobial and anticancer drugs such as ery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e491ded97c31c48deeb16b1fe9f8ff
https://pubmed.ncbi.nlm.nih.gov/31318855
https://pubmed.ncbi.nlm.nih.gov/31318855
Autor:
Binuraj R. K. Menon
Publikováno v:
Nature Chemistry. 13:714-714
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fde81bb9792507b070a47eab49f5819
https://doi.org/10.1038/s41557-021-00710-5
https://doi.org/10.1038/s41557-021-00710-5
Autor:
Matthew R, Bennett, Mark L, Thompson, Sarah A, Shepherd, Mark S, Dunstan, Abigail J, Herbert, Duncan R M, Smith, Victoria A, Cronin, Binuraj R K, Menon, Colin, Levy, Jason, Micklefield
Publikováno v:
Angewandte Chemie (International Ed. in English)
Benzylisoquinoline alkaloids (BIAs) are a structurally diverse family of plant secondary metabolites, which have been exploited to develop analgesics, antibiotics, antitumor agents, and other therapeutic agents. Biosynthesis of BIAs proceeds via a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ecd4d586c84f8e837f7a6b323e07049
https://pubmed.ncbi.nlm.nih.gov/29791083
https://pubmed.ncbi.nlm.nih.gov/29791083
Autor:
Eileen Brandenburger, Binuraj R. K. Menon, Jonathan Latham, Jason Micklefield, Sarah A. Shepherd
Publikováno v:
Latham, J, Brandenburger, E, Shepherd, S, Menon, B & Micklefield, J 2018, ' Development of Halogenase Enzymes for Use in Synthesis ', Chemical Reviews, vol. 118, no. 1, pp. 232–269 .
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of biosynthetic precursors, with the halogens introduced often having a profound effect on the biological activity of the resulting natural products. Synthetic endea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16096ea9e38c8942f0a935d0d79b8f30
https://www.research.manchester.ac.uk/portal/en/publications/development-of-halogenase-enzymes-for-use-in-synthesis(41d27fa3-d6d3-49a9-92ea-405527679f4b).html
https://www.research.manchester.ac.uk/portal/en/publications/development-of-halogenase-enzymes-for-use-in-synthesis(41d27fa3-d6d3-49a9-92ea-405527679f4b).html
Autor:
C. V. Karthikeyan, Mark L. Thompson, Colin Levy, Binuraj R. K. Menon, David Leys, Matthew Q. Styles, Sarah A. Shepherd, Anna-Winona Struck, Jonathan Latham, Jason Micklefield
Publikováno v:
Shepherd, S, Chinnan Velmurugan, K, Latham, J, Struck, A-W, Thompson, M, Menon, B, Styles, M, Levy, C, Leys, D & Micklefield, J 2015, ' Extending the Biocatalytic Scope of Regiocomplementary Flavin-Dependent Halogenase Enzymes ', Chemical Science, vol. 6, pp. 3454-3460 . https://doi.org/10.1039/C5SC00913H
Flavin-dependent halogenases are potentially valuable biocatalysts for the regioselective halogenation of aromatic compounds. These enzymes, utilising benign inorganic halides, offer potential advantages over traditional non-enzymatic halogenation ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb38a2fb617aebb90628a2d6fd359f05
https://doi.org/10.1039/c5sc00913h
https://doi.org/10.1039/c5sc00913h