Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Binu Tharakan"'
Autor:
Bobby D. Robinson, Claire L. Isbell, Anu R. Melge, Angela M. Lomas, Chinchusha Anasooya Shaji, C. Gopi Mohan, Jason H. Huang, Binu Tharakan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection against secondary injuries following traumatic brain injury (TBI). Microvascular hyperperme
Externí odkaz:
https://doaj.org/article/2356e89712b944149e98f1ef54b49734
Autor:
Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong, Xu Peng
Publikováno v:
Clinical and Translational Medicine, Vol 6, Iss 1, Pp 1-5 (2017)
Abstract Background Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart
Externí odkaz:
https://doaj.org/article/069ffd40d78f423d9d9ca45e40bbe8d2
Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer’s disease
Autor:
Gabriela Seplovich, Yazan Bouchi, Juan Pablo de Rivero Vaccari, Jennifer C. Munoz Pareja, Andrew Reisner, Laura Blackwell, Yehia Mechref, Kevin K. Wang, J. Adrian Tyndall, Binu Tharakan, Firas Kobeissy
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 6, Pp 1644-1664 (2025)
Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer’s disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the p
Externí odkaz:
https://doaj.org/article/741913501cac42edb488a2c4254fcde5
Autor:
Himakarnika Alluri, Rickesha L Wilson, Chinchusha Anasooya Shaji, Katie Wiggins-Dohlvik, Savan Patel, Yang Liu, Xu Peng, Madhava R Beeram, Matthew L Davis, Jason H Huang, Binu Tharakan
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154427 (2016)
Microvascular hyperpermeability that occurs at the level of the blood-brain barrier (BBB) often leads to vasogenic brain edema and elevated intracranial pressure following traumatic brain injury (TBI). At a cellular level, tight junction proteins (TJ
Externí odkaz:
https://doaj.org/article/93f1622d98e241efa0d0f3d8c0d3d952
Publikováno v:
Journal of Neurotrauma. 40:502-513
Traumatic brain injury (TBI) is a major cause of death and disability in the United States, exacting a debilitating physical, social, and financial strain. Therefore, it is crucial to examine the impact of TBI on medically underserved communities in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e424583f0d945bd71d793dc0f3d70b
https://doi.org/10.1089/neu.2021.0455
https://doi.org/10.1089/neu.2021.0455
Autor:
Aliyah Anderson, O'lisa Yaa Waithe, Saravanakumar Muthusamy, Gabriela Seplovich, Oluwatoyin Olagunju, Binu Tharakan
Publikováno v:
Physiology. 38
The blood-brain barrier (BBB) is a semi-permeable and protective barrier of the brain, primarily composed of endothelial cells interconnected by tight junction proteins, that regulates the movement of ions and molecules between the blood and the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e1ea16e0f1e8a6e6cb09ed49f88978c
https://doi.org/10.1152/physiol.2023.38.s1.5732827
https://doi.org/10.1152/physiol.2023.38.s1.5732827
Autor:
Binu, Tharakan, Felicia A, Hunter, Saravanakumar, Muthusamy, Sonya, Randolph, Crystal, Byrd, Veena N, Rao, E Shyam P, Reddy, Ed W, Childs
Publikováno v:
Shock. 57:309-315
ERG (ETS-related gene) is a member of the ETS (Erythroblast-transformation specific) family of transcription factors abundantly present in vascular endothelial cells. Recent studies demonstrate that ERG has important roles in blood vessel stability a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a609b0207c96c8c6e93e086dbb764e
https://doi.org/10.1097/shk.0000000000001899
https://doi.org/10.1097/shk.0000000000001899
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0fcd3e5244737be4507f9889b5fa88f
https://doi.org/10.1096/fasebj.2022.36.s1.r6191
https://doi.org/10.1096/fasebj.2022.36.s1.r6191
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75a83015109e1dc3149bec6a072af14f
https://doi.org/10.1096/fasebj.2022.36.s1.r5129
https://doi.org/10.1096/fasebj.2022.36.s1.r5129
Autor:
Binu Tharakan, Felicia A. Hunter, Saravanakumar Muthusamy, O'lisa Y. Waithe, Veena N. Rao, E. Shyam P. Reddy, Ed W. Childs
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7edd9973e43ab1fab610a58ed9dac8
https://doi.org/10.1096/fasebj.2022.36.s1.r5832
https://doi.org/10.1096/fasebj.2022.36.s1.r5832