Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Binod Jacob"'
Autor:
Kyathanahalli S. Janardhan, Radhakrishna Sura, Smita Salian-Mehta, Thierry Flandre, Xavier Palazzi, Doris Zane, Bhanu Singh, Binod Jacob, Renee Rosemary Hukkanen, Muthafar Al-Haddawi, Bindu Bennet, Victoria Laast, Donna Lee, Richard Peterson, Annette Romeike, Frederic Schorsch, Magali Guffroy
Publikováno v:
Toxicologic pathology. 50(8)
Nonclinical toxicology studies that are required to support human clinical trials of new drug candidates are generally conducted in a rodent and a non-rodent species. These studies typically contain a vehicle control group and low, intermediate, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2273f2dc43a1f87ae26f6ebf23230e3
https://pubmed.ncbi.nlm.nih.gov/36226581
https://pubmed.ncbi.nlm.nih.gov/36226581
Autor:
Michael S. Thibodeau, Manoj Bhaskaran, Aleksandra Zalewska, Balasubramanian Manickam, Justin D. Vidal, Jonathan Werner, Wendy G. Halpern, Karyn Colman, Sean McKeag, Benjamin Sefing, Darren Fegley, Karen S. Regan, Binod Jacob, Eveline de Rijk, Vimala Vemireddi, George A. Parker, Hitoshi Kandori
Publikováno v:
Toxicologic Pathology. 49:977-989
The sexual maturity status of animals in nonclinical safety studies can have a significant impact on the microscopic assessment of the reproductive system, the interpretation of potential test article–related findings, and ultimately the assessment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b875dc51afa16eb8629752f0d10e9768
https://doi.org/10.1177/0192623321990631
https://doi.org/10.1177/0192623321990631
Autor:
Anna-Mari Karkkainen, Philip Manfre, Elaine O’Loughlin, Juha Kuosmanen, Gonzalo Zeballos Zeballos, Kimmo Lehtimäki, Binod Jacob, Takayuki Tsuchiya, Geoffrey B. Varty, Matthew E. Kennedy, Nicholas T Gatto, Thomas W. Rosahl, Sophia Bardehle, Christian Mirescu, Anjali McCullough
Advances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimental in vivo models with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d07f472de9c117ab0bb2ba15fbe88e
https://doi.org/10.1101/2020.12.17.423334
https://doi.org/10.1101/2020.12.17.423334
Autor:
Nicole Navratil, Melanie A. Greeley, Kristi L. Helke, Vimala Vemireddi, Sean McKeag, Binod Jacob, Alain Stricker-Krongrad, Keith N. Nelson, Julius Haruna, Charlotte Hollinger, Aaron M. Sargeant, Derek Brocksmith
Publikováno v:
Toxicologic pathology. 44(3)
Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species. Although swine have been used extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d05ffa6ca6f22fda60201fc94f63016
https://pubmed.ncbi.nlm.nih.gov/26534940
https://pubmed.ncbi.nlm.nih.gov/26534940
Publikováno v:
Handbook of Toxicology, Third Edition ISBN: 9781439890134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06ec72a31f35fbf24cd2c0795d71691c
https://doi.org/10.1201/b16632-2
https://doi.org/10.1201/b16632-2
Publikováno v:
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 19(3)
Fourteen cattle on a Kansas pasture died from ingestion of a wood preservative compound containing sodium fluoride and copper naphthenate. Clinical signs included depression, anorexia, ataxia, diarrhea, and recumbency. Grossly visible lesions include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbd0f2fd4b947e0c1dce665231fada
https://pubmed.ncbi.nlm.nih.gov/17459864
https://pubmed.ncbi.nlm.nih.gov/17459864
Publikováno v:
Handbook of Toxicology, Second Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6782775d5e5b8aba2ccad988e5a742
https://doi.org/10.1201/9781420042078.ch1
https://doi.org/10.1201/9781420042078.ch1