Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Binlu Huang"'
Autor:
Yibing Bai, Tongzhou Li, Qinshu Wang, Weiqiang You, Haochen Yang, Xintian Xu, Ziyi Li, Yu Zhang, Chengsong Yan, Lei Yang, Jiaqian Qiu, Yuanhua Liu, Shiyang Chen, Dongfang Wang, Binlu Huang, Kexin Liu, Bao- Liang Song, Zhuozhong Wang, Kang Li, Xin Liu, Guangchuan Wang, Weiwei Yang, Jianfeng Chen, Pei Hao, Zemin Zhang, Zhigang Wang, Zheng-Jiang Zhu, Chenqi Xu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 334-360 (2024)
Abstract Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC). It is therefore important to study tu
Externí odkaz:
https://doaj.org/article/a0b9d1b7b5d2433d90da1229130e43db
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 5, Pp 737-750 (2013)
Abstract Wnt/β‐catenin signalling is widely implicated in embryogenesis, tissue homeostasis and tumorigenesis. The key event in Wnt signalling activation is β‐catenin accumulation, which is controlled by both its production and degradation. How
Externí odkaz:
https://doaj.org/article/82fa8314413642d7a5cd03a33e5deae3
Publikováno v:
The Journal of Cell Biology
Kapinos et al. show that nuclear pore complex permeability and cargo release functionalities are concomitantly regulated by karyopherin occupancy and turnover in a systematic continuum. This highlights increasingly important roles for the soluble nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a72074c4f7dea53da9c02809cfc16b
https://doi.org/10.1083/jcb.201702092
https://doi.org/10.1083/jcb.201702092
Publikováno v:
Nature metabolism. 2(2)
Cholesterol metabolism produces essential membrane components as well as metabolites with a variety of biological functions. In the tumour microenvironment, cell-intrinsic and cell-extrinsic cues reprogram cholesterol metabolism and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad64a7f3616a8344c8676315236b2e47
https://pubmed.ncbi.nlm.nih.gov/32694690
https://pubmed.ncbi.nlm.nih.gov/32694690
Publikováno v:
NUCLEUS
Nuclear pore complexes (NPCs) mediate molecular transport between the nucleus and cytoplasm in eukaryotic cells. Tethered within each NPC lie numerous intrinsically disordered proteins known as FG nucleoporins (FG Nups) that are central to this proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42260744b4fadcaaa557a4199b2873fd
https://doi.org/10.1080/19491034.2015.1090061
https://doi.org/10.1080/19491034.2015.1090061
Autor:
Guixin Zhu, Yajie Ding, Binlu Huang, Fan Zhongyun, Libing Mu, Miao Ding, Wei Wu, Juan Liang, Yu Fu
Publikováno v:
Journal of Biological Chemistry. 289:15482-15494
The Rac1/JNK cascade plays important roles in DNA damage-induced apoptosis. However, how this cascade is activated upon DNA damage remains to be fully understood. We show here that, in untreated cells, Tiam1, a Rac1-specific guanine nucleotide exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c89b37321bb1bd854a47b310e8440a2
https://doi.org/10.1074/jbc.m114.553388
https://doi.org/10.1074/jbc.m114.553388
Publikováno v:
EMBO Molecular Medicine
Wnt/β-catenin signalling is widely implicated in embryogenesis, tissue homeostasis and tumorigenesis. The key event in Wnt signalling activation is β-catenin accumulation, which is controlled by both its production and degradation. However, much mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f25161e89103dac97dca6a66ebe1450
https://doi.org/10.1002/emmm.201202218
https://doi.org/10.1002/emmm.201202218
Autor:
Ye-Guang Chen, Christof Niehrs, Lei Gao, Binlu Huang, Yu Fu, Wei Wu, Ying Wang, Ursula Fenger, Guixin Zhu, Chan Gao, Juan Liang
Publikováno v:
Journal of Biological Chemistry. 285:10890-10901
The beta-catenin-lymphoid enhancer factor (LEF) protein complex is the key mediator of canonical Wnt signaling and initiates target gene transcription upon ligand stimulation. In addition to beta-catenin and LEF themselves, many other proteins have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f5067b0578735c64ad74a3842a1ceb
https://doi.org/10.1074/jbc.m109.058347
https://doi.org/10.1074/jbc.m109.058347
Publikováno v:
Genesdevelopment. 27(12)
The R-spondin (RSPO) family of secreted proteins (RSPO1–RSPO4) has pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. Recently, leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32a2b4530c566ddb3cc59fbf952ab28
https://pubmed.ncbi.nlm.nih.gov/23756652
https://pubmed.ncbi.nlm.nih.gov/23756652
Publikováno v:
Journal of genetics and genomics = Yi chuan xue bao. 36(6)
The human pituitary tumor transforming gene (hPTTG) serves as a marker for malignancy grading in several cancers. hPTTG is involved in multiple cellular pathways including cell transformation, apoptosis, DNA repair, genomic instability, mitotic contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a88e4bde3a1bb68133f56273c3fed4a
https://pubmed.ncbi.nlm.nih.gov/19539243
https://pubmed.ncbi.nlm.nih.gov/19539243