Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Binliang Zhang"'
Autor:
Lide Yu, Qinqin Wang, Caolin Wang, Binliang Zhang, Zunhua Yang, Yuanying Fang, Wufu Zhu, Pengwu Zheng
Publikováno v:
Molecules, Vol 24, Iss 19, p 3422 (2019)
Three series of novel thienopyrimidine derivatives 9a−l, 15a−l, and 18a−h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicit
Externí odkaz:
https://doaj.org/article/cd9a5b279d8547d7ba87fbbd38d36a8e
Publikováno v:
Molecules, Vol 23, Iss 7, p 1553 (2018)
Five series of novel phenylsulfonylurea derivatives, 19a–d, 20a–d, 21a–d, 22a–d and 23a–d, bearing 4-phenylaminoquinoline scaffold were designed, synthesized and their IC50 values against four cancer cell lines (HepG-2, A549, PC-3 and MCF-7
Externí odkaz:
https://doaj.org/article/48ccffc2960e4f138645d10ba69703bf
Publikováno v:
Molecules, Vol 22, Iss 11, p 1870 (2017)
Phosphatidylinositol 3-kinase/Protein kinase B/Mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is abnormally active in the growth and proliferation of cancer cells. The inhibition of PI3K kinase can effectively block the conduction of
Externí odkaz:
https://doaj.org/article/d30b93edcbd84a159faede28d9dc245d
Autor:
Xin Sun, Binliang Zhang, Leixuan Luo, Yang Yang, Bin He, Qian Zhang, Linxiao Wang, Shan Xu, Pengwu Zheng, Wufu Zhu
Publikováno v:
Bioorganic chemistry. 129
Blocking the PI3K/AKT/mTOR pathway has been widely recognized as an attractive cancer therapeutic strategy because of its crucial role in cell growth and survival. In this study, a novel series of 2-arylurea-1,3,5-triazine derivatives had been synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4791160941230c4cb5e765e20d199895
https://pubmed.ncbi.nlm.nih.gov/36587506
https://pubmed.ncbi.nlm.nih.gov/36587506
Publikováno v:
RSC chemical biology. 3(10)
Nucleic acids have been extensively modified in different moieties to expand the scope of genetic materials in the past few decades. While the development of unnatural base pairs (UBPs) has expanded the genetic information capacity of nucleic acids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311386595631fe9274bd7309b972e06c
https://pubmed.ncbi.nlm.nih.gov/36320892
https://pubmed.ncbi.nlm.nih.gov/36320892
Autor:
Xin Sun, Zunhua Yang, Qian Zhang, Xiaobo Liu, Pengwu Zheng, Binliang Zhang, Wufu Zhu, Shan Xu, Hehua Xiong
Publikováno v:
New Journal of Chemistry. 44:9053-9063
Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moieties (compounds 21a–l and 22a–l) were designed and their IC50 values were evaluated against three cancer cell lines (A549, MCF-7 and HeLa) and c-Met kinase. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1e7e0277573dfa8f617d6a97b0e87b
https://doi.org/10.1039/d0nj00575d
https://doi.org/10.1039/d0nj00575d
Autor:
Xin Sun, Binliang Zhang, Leixuan Luo, Yang Yang, Bin He, Qian Zhang, Linxiao Wang, Shan Xu, Pengwu Zheng, Wufu Zhu
Publikováno v:
Bioorganic Chemistry. 131:106336
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c9dee78d6a36a9b375ee4bbcb811a2
https://doi.org/10.1016/j.bioorg.2022.106336
https://doi.org/10.1016/j.bioorg.2022.106336
Autor:
Wufu Zhu, Qinqin Wang, Zunhua Yang, Shan Xu, Lai Luogen, Qi Yang, Zixin Luo, Binliang Zhang, Zhen Xiao
Publikováno v:
RSC Advances. 9:29579-29589
A series of thienopyrimidines containing a pyrazoline unit (4a–d, 7a–d and 13a–l) were designed and synthesized. The target compounds were evaluated for antiproliferative activity against A549, HepG2 and MCF-7 cancer cell lines. Among the twent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f56284595a507044f625e872f37090
https://doi.org/10.1039/c9ra06192d
https://doi.org/10.1039/c9ra06192d
Autor:
Ting Xie, Wufu Zhu, Shan Xu, Binliang Zhang, Qi Gu, Pengwu Zheng, Ziqin Liu, Zhen Xiao, Xin Sun, Qian Zhang, Zunhua Yang, Qingqing Jin
Publikováno v:
Bioorganic chemistry. 95
The phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been regarded as promising targets for the treatment of cancer. Herein, we synthesized a new series of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a92153507194ed71fe9e98db4b7c25
https://pubmed.ncbi.nlm.nih.gov/31887474
https://pubmed.ncbi.nlm.nih.gov/31887474
Autor:
Wufu Zhu, Lide Yu, Yuanying Fang, Zunhua Yang, Caolin Wang, Pengwu Zheng, Binliang Zhang, Qinqin Wang
Publikováno v:
Molecules, Vol 24, Iss 19, p 3422 (2019)
Molecules
Volume 24
Issue 19
Molecules
Volume 24
Issue 19
Three series of novel thienopyrimidine derivatives 9a&ndash
l, 15a&ndash
l, and 18a&ndash
h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compound
l, 15a&ndash
l, and 18a&ndash
h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb24c47373cb6ff9ce19cd2c0cd50b52
https://www.mdpi.com/1420-3049/24/19/3422
https://www.mdpi.com/1420-3049/24/19/3422