Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Binli Tao"'
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83062 (2013)
Cystin is a novel cilia-associated protein that is disrupted in the cpk mouse, a well-characterized mouse model of autosomal recessive polycystic kidney disease (ARPKD). Interestingly, overexpression of the Myc gene is evident in animal models of ARP
Externí odkaz:
https://doaj.org/article/61897734627f4bbc8fc2f9d31b483abf
Publikováno v:
Physiology. 38
The circadian clock regulates Na+ transport with a necessary diurnal variation for optimal health. The clock gene, Bmal1, is known to regulate mitochondrial O2 consumption, but whether or how this occurs in the kidney has not been established. An est
Autor:
Dingguo Zhang, Joshua S. Speed, John Miller Allan, Chunhua Jin, Megan K Rhoads, David M. Pollock, Reham H Soliman, Jennifer S. Pollock, Ijeoma E. Obi, Randee Sedaka, Binli Tao
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F710-F719
Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor Bmal1. A high-salt diet induces a phase shift in Bmal1 expression in the renal inner medulla that is dependent on endothelin type B (ETB
Autor:
Dingguo Zhang, Paramita Pati, Thomas H. Neder, Malgorzata Kasztan, Jennifer S. Pollock, Jennifer A Valcin, Binli Tao, Karen L. Gamble, Bryan K. Becker, Jodi R. Paul, Chunhua Jin, Jackson Colson, David M. Pollock, Megan K Rhoads, McKenzi A King, Shannon M. Bailey
Publikováno v:
Function (Oxford, England)
Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL/6J mice were fed ad
Autor:
Megan K Rhoads, Malgorzata Kasztan, Joshua S. Speed, Reham H Soliman, Binli Tao, Jermaine G. Johnston, Bryan K. Becker, Kelly A. Hyndman, Aron M. Geurts, Chunhua Jin, David M. Pollock, Jennifer S. Pollock
Publikováno v:
Hypertension
The diurnal rhythms of sodium handling and blood pressure are thought to be regulated by clock genes, such as Bmal1. However, little is known about the regulation of these factors by Bmal1, especially in rats. Using a novel whole-body Bmal1 knockout
Publikováno v:
Hypertension. 72
Kidney function follows a 24-hour rhythm that is subject to regulation by so-called circadian clock genes. Previous studies suggested a potential role of circadian gene Bmal1 in regulating renal excretory function and blood pressure, yet the mechanis
Publikováno v:
Journal of Biological Chemistry. 286:41937-41948
Most cystic fibrosis (CF) cases are caused by the ΔF508 mutation in the CF transmembrane conductance regulator (CFTR), which disrupts both the processing and gating of this chloride channel. The cell surface expression of ΔF508-CFTR can be “rescu
Publikováno v:
Acta Physiologica. 225:e13178
AIM The objective of this study is to determine if ambrisentan (ETA selective antagonist) and hydroxyurea (HU) treatment has a synergistic effect on renal injury in sickle cell nephropathy when compared to HU treatment alone. The premise of the study
Autor:
Binli Tao, Patricia N. Fultz
Publikováno v:
Virology. 259(1):166-175
During 14 months of infection of a pig-tailed macaque, the acutely lethal simian immunodeficiency virus SIVsmmPBj14 (SIV-PBj14) evolved from the minimally pathogenic strain SIVsmm9. The virus isolated at 8 months (SIV-PBj8) exhibited properties of bo
Autor:
Lisa M. Guay-Woodford, Binli Tao, John C. Kappes, Andreas Kispert, Brian J. Siroky, Su Bu, Zhihua Yang
Publikováno v:
Journal of the American Society of Nephrology : JASN. 20(12)
Primary cilia are dynamic, complex structures that contain 500 proteins, including several related to polycystic kidney disease. How these proteins target to cilia and assemble is unknown. We previously identified Cys1 as the gene responsible for dis