Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Binhua Ling"'
Autor:
Lakmini S. Premadasa, Eunhee Lee, Marina McDew-White, Xavier Alvarez, Sahana Jayakumar, Binhua Ling, Chioma M. Okeoma, Siddappa N. Byrareddy, Smita Kulkarni, Mahesh Mohan
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Intestinal epithelial barrier dysfunction, a hallmark of HIV/SIV infection, persists despite viral suppression by combination antiretroviral therapy (cART). Emerging evidence suggests a critical role for long noncoding RNAs (lncRNAs) in maintaining e
Externí odkaz:
https://doaj.org/article/b8aaee08e439447b9b63705218dcdf2e
Autor:
Sahil Shah, Lilly M. Wong, Kendra Ellis, Brittany Bodnar, Sami Saribas, Julia Ting, Zhengyu Wei, Yuyang Tang, Xianwei Wang, Hong Wang, Binhua Ling, David M. Margolis, J. Victor Garcia, Wenhui Hu, Guochun Jiang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Adeno-associated virus (AAV)-mediated genetic targeting of microglia remains a challenge. Overcoming this hurdle is essential for gene editing in the central nervous system (CNS). Here, we characterized the minimal/native promoter of the HEXB gene, w
Externí odkaz:
https://doaj.org/article/54a2bdcd07e54840b12bb705d5db3997
Autor:
Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo, Kamel Khalili
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno-associated virus-based CRISPR/Cas9 gene editing construct to SIV-infected macaques results in excision of integrated
Externí odkaz:
https://doaj.org/article/8cbe71bbcb2e47d19d5219446802dbe4
Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy
Autor:
Antonio Solis-Leal, Summer Siddiqui, Fei Wu, Mahesh Mohan, Wenhui Hu, Lara A. Doyle-Meyers, Jason P. Dufour, Binhua Ling
Publikováno v:
Viruses, Vol 14, Iss 1, p 139 (2022)
The central nervous system (CNS) HIV reservoir is an obstacle to achieving an HIV cure. The basal ganglia harbor a higher frequency of SIV than other brain regions in the SIV-infected rhesus macaques of Chinese-origin (chRMs) even on suppressive comb
Externí odkaz:
https://doaj.org/article/176c6391be914032b081df1824e3bcdd
Autor:
Summer Siddiqui, Stefanie Perez, Yong Gao, Lara Doyle-Meyers, Brian T Foley, Qingsheng Li, Binhua Ling
Publikováno v:
Viruses, Vol 11, Iss 2, p 105 (2019)
Understanding HIV latent reservoirs in tissues is essential for the development of new strategies targeting these sites for eradication. Here, we assessed the size of latent reservoirs and the source of residual viruses in multiple lymphoid tissues o
Externí odkaz:
https://doaj.org/article/5ff305e0874640bca7ac9686ab0c8807
Autor:
Binhua Ling, Michael Piatak, Linda Rogers, Ann-Marie Johnson, Kasi Russell-Lodrigue, Daria J Hazuda, Jeffrey D Lifson, Ronald S Veazey
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102795 (2014)
Viral reservoirs-persistent residual virus despite combination antiretroviral therapy (cART)-remain an obstacle to cure of HIV-1 infection. Difficulty studying reservoirs in patients underscores the need for animal models that mimics HIV infected hum
Externí odkaz:
https://doaj.org/article/64ee1143fee94ba99bf4d8499b3e3c99
Autor:
Jeremiah D Degenhardt, Paola de Candia, Adrien Chabot, Stuart Schwartz, Les Henderson, Binhua Ling, Meredith Hunter, Zhaoshi Jiang, Robert E Palermo, Michael Katze, Evan E Eichler, Mario Ventura, Jeffrey Rogers, Preston Marx, Yoav Gilad, Carlos D Bustamante
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000346 (2009)
Variation in genes underlying host immunity can lead to marked differences in susceptibility to HIV infection among humans. Despite heavy reliance on non-human primates as models for HIV/AIDS, little is known about which host factors are shared and w
Externí odkaz:
https://doaj.org/article/aef92161213745ddaa6043f88e71a440
Autor:
Antonio Solis-Leal, Nongthombam Boby, Suvadip Mallick, Yilun Cheng, Fei Wu, Grey De La Torre, Jason Dufour, Xavier Alvarez, Vinay Shivanna, Yaozhong Liu, Christine M Fennessey, Jeffrey D Lifson, Qingsheng Li, Brandon F Keele, Binhua Ling
Publikováno v:
bioRxiv
The rebound-competent viral reservoir (RCVR), comprised of virus that is able to persist during antiretroviral therapy (ART) and mediate reactivation of systemic viral replication and rebound viremia after antiretroviral therapy interruption (ATI), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a4de588da68de0e78ce719808d184b
https://europepmc.org/articles/PMC10312542/
https://europepmc.org/articles/PMC10312542/
Publikováno v:
Journal of medical virologyREFERENCES. 95(1)
The gut is a major reservoir in HIV-infected individuals on antiretroviral therapy (ART) and in long-term non-progressors (LTNPs). Whether ART reduces gut infection and reservoirs in LTNPs is unknown. Herein, SIV-infected LTNP Rhesus macaques were tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867c375052446e4f58b3cf9d805608d7
https://pubmed.ncbi.nlm.nih.gov/36181356
https://pubmed.ncbi.nlm.nih.gov/36181356
Publikováno v:
Brief Bioinform
Ribonucleic acid (RNA)-seq data contain not only host transcriptomes but also nonhost information that comprises transcripts from active microbiota in the host cells. Therefore, joint and integrative analyses of both host and meta-transcriptome can r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf2cf67eca5f1e9eae4e05100005b35
https://doi.org/10.1093/bib/bbac111
https://doi.org/10.1093/bib/bbac111