Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Bingyuan Ji"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7324-7338 (2024)
Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved
Externí odkaz:
https://doaj.org/article/f5fcc34011144430baeaef891122c010
Autor:
Rumin Zhang, Dandan Li, Huiling Mao, Xiaonan Wei, MingDong Xu, Shengnan Zhang, Yunlu Jiang, Chunmei Wang, Qing Xin, Xiaoyu Chen, Guorong Li, Bingyuan Ji, Maocai Yan, Xin Cai, Bo Dong, Harpal S. Randeva, Chuanxin Liu, Jing Chen
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract G protein-coupled receptor (GPCR) heterodimers are new targets for the treatment of depression. Increasing evidence supports the importance of serotonergic and orexin-producing neurons in numerous physiological processes, possibly via a cruc
Externí odkaz:
https://doaj.org/article/05e4dc3ad34b451d81a6473323282b1f
Publikováno v:
Cells, Vol 11, Iss 23, p 3897 (2022)
Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous disease that primarily results from impaired insulin secretion or insulin resistance (IR). G protein-coupled receptors (GPCRs) are proposed as therapeutic targets for T2DM. GPCRs transduc
Externí odkaz:
https://doaj.org/article/e18a06eb3a8f4631a5d90204a308289e
Autor:
Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang, Jing Chen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function. We investigated the effec
Externí odkaz:
https://doaj.org/article/d9327eb1eda3469a941cf56a33593d5e
Autor:
Jing Chen, Xiaoyu Chen, Sheng Li, Yunlu Jiang, Huiling Mao, Rumin Zhang, Bingyuan Ji, Maocai Yan, Xin Cai, Chunmei Wang
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101629- (2020)
The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within the C-terminus of APJ is essential for the recruitment of β-arrestins.
Externí odkaz:
https://doaj.org/article/d2ca35ccbd0f4a558b86ce368f8b8b8f
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increas
Externí odkaz:
https://doaj.org/article/82cbb9800c04456a821d0b836b67d710
Autor:
Qingjie Xue, Xiuzhen Li, Chunqing Yang, Bingyuan Ji, Yunqing Li, Yingchun Yan, Xinxin Yang, Chunmei Wang, Ting Chen
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 10, Pp 2260-2268 (2017)
In this study, purified GM-CSF and LMP2A mRNAs were amplified by PCR. Then, the GM-CSF and LMP2A sequences were connected by the polypeptide linker (Gly4Ser)3 using gene splicing by overlap extension. The constructed fusion gene GC2A was inserted int
Externí odkaz:
https://doaj.org/article/ab56e8a89f114ab7b2e95ef13975472f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains u
Externí odkaz:
https://doaj.org/article/b95284a5e1cf475f8009fe61dee4dae2
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Extracellular signal-regulated kinase 1/2 (ERK1/2), an important member of the mitogen-activated protein kinase family, is found in many organisms, and it participates in intracellular signal transduction. Various stimuli induce phosphorylation of ER
Externí odkaz:
https://doaj.org/article/92e7f78a2f8e40778c1abf86ddc387a2
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Hyaluronan and proteoglycan link protein 2 (Hapln2) is important for the binding of chondroitin sulfate proteoglycans to hyaluronan. Hapln2 deficiency leads to the abnormal expression of extracellular matrix (ECM) proteins and dysfunctional neuronal
Externí odkaz:
https://doaj.org/article/e5d27e99538341c294160621a9704776