Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bingwei V Yang"'
Autor:
Joel C. Barrish, Aberra Fura, Guoxiang Shen, Jingwu Duan, David S. Nirschl, Jonathan Lippy, Stephen T. Wrobleski, Rosemary Zhang, Lidia M. Doweyko, Bingwei V. Yang, Lauren Haque, Murray McKinnon, Shuqun Lin, Luisa Salter-Cid, Sidney Pitt, William J. Pitts, Percy H. Carter, John S. Sack, Gary L. Schieven, Bin Jiang, John Hynes, Gregory D. Brown, John S. Tokarski, Zhonghui Lu, Javed Khan, Steven G. Nadler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5721-5726
A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold. Preliminary studies identified (R)-(2,2-dimethylcyclopentyl)amine as a preferred C4 substituent on the pyrrolopyr
Autor:
Jingwu Duan, Stephen T. Wrobleski, Joel C. Barrish, Jagabandhu Das, Gary L. Schieven, Steven H. Spergel, Charu Chaudhry, Percy H. Carter, John S. Tokarski, Damaso Ovalle, John S. Sack, Aberra Fura, Zhonghui Lu, James Kempson, Luisa Salter-Cid, William J. Pitts, Junqing Guo, Yuval Blatt, John Hynes, Shuqun Lin, Hong Wu, Bin Jiang, Bingwei V. Yang, Javed Khan
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(20)
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
Autor:
Robert M. Townsend, Hai Yun Xiao, Joel C. Barrish, Sium Habte, Arthur M. Doweyko, Steven G. Nadler, Hua Gong, Bingwei V. Yang, John H. Dodd, Tram N. Huynh, John E. Somerville, Mark D. Cunningham, Lorraine I. McKay, David J. Shuster, Michele McMahon, David S. Weinstein, Lidia M. Doweyko, Wayne Vaccaro, Deborah A. Holloway
Publikováno v:
Journal of Medicinal Chemistry. 53:8241-8251
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification of 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepr
Autor:
Bingwei V. Yang, Lidia M. Doweyko
Publikováno v:
Tetrahedron Letters. 46:2857-2860
The highly regioselective Diels–Alder reactions of 9-substituted anthracenes and 2-acetamidoacrylate afford a series of novel and conformationally constrained bicyclic bisaryl α-amino acids.
Autor:
Margaret A. Rushing, Sheryl L. Santoro, Barbara J. Kamicker, Bingwei V Yang, Michael A. Letavic, Camilla D. Bertsche, Bronk Brian Scott, Laura J. L. Norcia, Shigeru F. Hayashi, Nicole L. Kolosko, David M. George
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1955-1958
Modification of the cladinose C-4" position via manipulation of the corresponding keto derivatives afforded two stereochemically pure series of compounds. The synthesis and structure determination of these compounds is described within. The in vitro
Autor:
Bingwei V. Yang, Mark A. Massa
Publikováno v:
The Journal of Organic Chemistry. 61:5149-5152
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:605-610
Helicobacter pylori urease is a nickel-containing enzyme that hydrolyzes urea to bicarbonate and ammonia. Andrews et al. (J. Am. Chem. Soc. 1986, 108, 7124) have shown that amides and esters of phosphoric acid are slow, tight-binding inhibitors of ur
Publikováno v:
The Journal of Organic Chemistry. 60:1285-1297
Publikováno v:
Tetrahedron Letters. 35:3025-3028
Beckmann rearrangement of erythromycin A 9(E)-oxime with toluenesulfonyl chloride in ethyl ether at −45°C generates 9,11-imino ether IV which leads to azithromycin. The 9,11-imino ether can also be readily obtained from isomerization of its isomer