Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bingidimi I. Mobele"'
Autor:
Christopher E. Katz, Bingidimi I. Mobele, Jalal Haddad, Yusuke Yamai, Kazuki Hashimoto, Yujiro Kiyoshima, Justin Caserta
Publikováno v:
Organic Process Research & Development.
Autor:
Yuh-Lin Yang, Min Hu, Shuang Liu, Brandon Miles, Bingidimi I. Mobele, Wenge Cui, Richard E. Olson, Rulin Zhao, Kassoum Nacro, Matthew Isherwood, Bei Wang, Paul C. Lobben, Rasidul Amin, Bang-Chi Chen
Publikováno v:
Organic Process Research & Development. 20:44-50
Herein, we describe the enabling synthesis of (+)-BMS-820836, a 4,7-disubstituted tetrahydroisoquinoline which was developed as a treatment for a range of neurological diseases, including depression and neurophatic pain. In order to advance the drug
Autor:
Bingidimi I. Mobele, Luckner Ulysse, Sripathy Venkatraman, Lawrence Lawless, Xuechuan Hong, Andrew Locke, Ravi Shanker Garigipati, Shengquan Duan, Kenneth He Huang, Alex Smith
Publikováno v:
Organic Process Research & Development. 16:1787-1793
A scalable process for the manufacture of a Hsp90 inhibitor was developed and optimized. Key features in the seven-step process include a selective SNAr reaction followed by an Ullmann-type coupling of indazolone to an aryl halide. This improved proc
Autor:
Kerry Spear, Sripathy Venkatraman, Bingidimi I. Mobele, Cameron Gibb, Brian E. Marron, Grant Andrew Mcnaughton-Smith, Stephen M. Shaw, Mark J. Suto, Luckner Ulysse, Carl A. Lindmark
Publikováno v:
Organic Process Research & Development. 16:1385-1392
A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized Grignard reaction, a direct cyanation of the intermediate trityl alcohol derivative, and an improv
Autor:
Farahnaz Mohammadi, Bingidimi I. Mobele, Luckner Ulysse, Michael D. Ironside, Taryn Kinahan, Graham S. Knox, Steven V. Gagnier
Publikováno v:
Organic Process Research & Development. 10:914-920
(+)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate hydrochloride (CTDP 31,446) is known as a dopamine reuptake inhibitor. This cocaine analogue lacking the tropane skeleton is being considered for potential treatment of cocaine addict
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 24
Publikováno v:
Tetrahedron Letters. 33:5567-5570
Bakers' yeast reduction of 3-acyltetrahydrothiopyran-4-ones is regio- and enantioselective, yielding predominantly (3R,4S)-3-acyl-4- hydroxytetrahydrothiopyranes with high optical purity. This reduction method coupled with the Raney-nickel desulfuriz
Publikováno v:
Tetrahedron Letters. 32:7055-7058
Publikováno v:
Tetrahedron Letters. 32:399-400
Bakers' yeast reduction of 2-phenyltiocyclopentanone, 2-phenylthiocyclohexanone, and 2-phenylthio-2-cyclopentenone affords the corresponding (1S,2R)-2-phenylthiocycloalkanols in optically pure form and excellent diastereomeric excess.