Zobrazeno 1 - 10 of 528 pro vyhledávání: '"Binghe, Wang"'
1
Akademický článek
Click chemistry and drug delivery: A bird's-eye view
Autor: Shameer M. Kondengadan, Shubham Bansal, Ce Yang, Dongning Liu, Zach Fultz, Binghe Wang
Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 1990-2016 (2023)
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. T
Externí odkaz: https://doaj.org/article/159e168f4a6245538a5e6628789ce0c4
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2
Akademický článek
Biotin conjugates in targeted drug delivery: is it mediated by a biotin transporter, a yet to be identified receptor, or (an)other unknown mechanism(s)?
Autor: Ravi Tripathi, Anchala Guglani, Rujuta Ghorpade, Binghe Wang
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Conjugation of drugs with biotin is a widely studied strategy for targeted drug delivery. The structure–activity relationship (SAR) studies through H3-biotin competition experiments conclude with the presence of a free carboxylic acid being essenti
Externí odkaz: https://doaj.org/article/b9a9f53c77814a6b840b49a26d930222
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3
Akademický článek
Upregulation of p53 through induction of MDM2 degradation: improved potency through the introduction of an alkylketone sidechain on the anthraquinone core
Autor: Ravi Tripathi, Abiodun Anifowose, Wen Lu, Xiaoxiao Yang, Binghe Wang
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2370-2381 (2022)
Overexpression of ubiquitin ligase MDM2 causes depletion of the p53 tumour-suppressor and thus leads to cancer progression. In recent years, anthraquinone analogs have received significant attention due to their ability to downregulate MDM2, thereby
Externí odkaz: https://doaj.org/article/1b1c5832c6254715b94a2b961073e185
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4
Akademický článek
A reservoir drying method for enhancing recovery of tight gas
Autor: Liehui ZHANG, Yu XIONG, Yulong ZHAO, Hongming TANG, Jingjing GUO, Chunsheng JIA, Qiang LEI, Binghe WANG
Publikováno v: Petroleum Exploration and Development, Vol 49, Iss 1, Pp 144-155 (2022)
Based on the study of damage mechanisms of generalized water blocking and related water-blocking removal methods, the drying agents for enhancing tight gas reservoir recovery were developed, and the basic properties, injection mode and drying effect
Externí odkaz: https://doaj.org/article/9535172493c943e396af6745afcb79b3
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5
Akademický článek
Nature's marvels endowed in gaseous molecules I: Carbon monoxide and its physiological and therapeutic roles
Autor: Xiaoxiao Yang, Wen Lu, Christopher P. Hopper, Bowen Ke, Binghe Wang
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1434-1445 (2021)
Nature has endowed gaseous molecules such as O2, CO2, CO, NO, H2S, and N2 with critical and diverse roles in sustaining life, from supplying energy needed to power life and building blocks for life's physical structure to mediating and coordinating c
Externí odkaz: https://doaj.org/article/a0c158f7ba8a44269dc5b79ed322d66c
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6
Akademický článek
Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage
Autor: Dominik Bakalarz, Marcin Surmiak, Xiaoxiao Yang, Dagmara Wójcik, Edyta Korbut, Zbigniew Śliwowski, Grzegorz Ginter, Grzegorz Buszewicz, Tomasz Brzozowski, Jakub Cieszkowski, Urszula Głowacka, Katarzyna Magierowska, Zhixiang Pan, Binghe Wang, Marcin Magierowski
Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 456-475 (2021)
Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity. We are interested in further development of metal-free CO-based therapeutics for oral
Externí odkaz: https://doaj.org/article/84974910c66e4a31b9e63f91767064e2
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8
Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor
Autor: Nicola Bauer, Xiaoxiao Yang, Zhengnan Yuan, Binghe Wang
Publikováno v: Chemical Science. 14:3215-3228
Redox activity and unreliable carbon monoxide production of CO donor, CORM-A1, presents new complications in its use for studying CO biology.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b47a71c938a31d22e3d0ac9b0f686ac8
https://doi.org/10.1039/d3sc00411b
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9
Akademický článek
Design and synthesis of benzopyran-based inhibitors of the hypoxia-inducible factor-1 pathway with improved water solubility
Autor: Jalisa H. Ferguson, Zeus De Los Santos, Saroja N. Devi, Stefan Kaluz, Erwin G. Van Meir, Sarah K. Zingales, Binghe Wang
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 992-1001 (2017)
While progress has been made in treating cancer, cytotoxic chemotherapeutic agents are still the most widely used drugs and are associated with severe side-effects. Drugs that target unique molecular signalling pathways are needed for treating cancer
Externí odkaz: https://doaj.org/article/5b1f57a865f84b7198b25962377a1156
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