Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Binggui Sun"'
Autor:
Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu, Xuekun Li
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-27 (2023)
Abstract Previous studies have shown that Ogt-mediated O-GlcNAcylation is essential for neuronal development and function. However, the function of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in astrocytes remains largely unknown. Here we show tha
Externí odkaz:
https://doaj.org/article/cff9bbf32161460396f938618c10ac86
Autor:
Jing Wang, Yufei Mei, Xiaoqin Zhang, Xiaojie Wei, Yiping Zhang, Dongpi Wang, Jinjin Huang, Keqing Zhu, Guoping Peng, Binggui Sun
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112152- (2023)
Summary: Hyperactivity of pyramidal neurons (PNs) in CA1 is an early event in Alzheimer’s disease. However, factors accounting for the hyperactivity of CA1 PNs remain to be completely investigated. In the present study, we report that the serotoner
Externí odkaz:
https://doaj.org/article/0645f90432734621b4a5b4183d0ec181
Autor:
Lauren Herl Martens, Jiasheng Zhang, Sami J. Barmada, Ping Zhou, Sherry Kamiya, Binggui Sun, Sang-Won Min, Li Gan, Steven Finkbeiner, Eric J. Huang, Robert V. Farese Jr
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/e1a9c0e0f6b14866a258fab75e500c8f
Autor:
Weize Xu, Xicheng Zhang, Feng Liang, Yuhang Cao, Ziyi Li, Wenzheng Qu, Jinyu Zhang, Yanhua Bi, Chongran Sun, Jianmin Zhang, Binggui Sun, Qiang Shu, Xuekun Li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Tet (Ten eleven translocation) family proteins-mediated 5-hydroxymethylcytosine (5hmC) is highly enriched in the neuronal system, and is involved in diverse biological processes and diseases. However, the function of 5hmC in astrocyte remains complet
Externí odkaz:
https://doaj.org/article/a24122d7dab44d058f7fb28a4625f8eb
Autor:
Yang He, Mengdi Wei, Yan Wu, Huaping Qin, Weinan Li, Xiaolin Ma, Jingjing Cheng, Jinshuai Ren, Ye Shen, Zhong Chen, Binggui Sun, Fu-De Huang, Yi Shen, Yu-Dong Zhou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly
Externí odkaz:
https://doaj.org/article/55e5dfe1d82d42c0af364801b3a94fc4
Autor:
Junchen Chen, Xiaoxue Dong, Xuejun Cheng, Qiang Zhu, Jinyu Zhang, Qian Li, Xiaoli Huang, Min Wang, Liping Li, Weixiang Guo, Binggui Sun, Qiang Shu, Wen Yi, Xuekun Li
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108905- (2021)
Summary: Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an important function in diverse biological processes and diseases. However, the roles of Ogt in regulating neurogenesis remain largely unknown. Here, we show that
Externí odkaz:
https://doaj.org/article/696d204f2c3e45bb805cae6e4f6415ee
Autor:
Lanqi Li, Yu Zhang, Binggui Sun, Heng Zhang, Wenyang Tao, Jinhu Tian, Xingqian Ye, Shiguo Chen
Publikováno v:
Journal of Functional Foods, Vol 40, Iss , Pp 554-563 (2018)
In the present study, the neuroprotective effects of Chinese bayberry leaves proanthocyanidin (BLPs) were investigated by targeting at Aβ fibrillization and neurotoxicity. Two types of BLPs, the Sephadex-LH20 purified BLPs (SPBLPs) and the ultrasoun
Externí odkaz:
https://doaj.org/article/784e4f138f9a49899b869cb274a85ee3
Autor:
Heng Zhang, Ling Zhang, Dongming Zhou, Xiao He, Dongpi Wang, Hongyu Pan, Xiaoqin Zhang, Yufei Mei, Qi Qian, Tingting Zheng, Frank E. Jones, Binggui Sun
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 171-180 (2017)
Accumulation of amyloid β (Aβ) induces neuronal, synaptic, and cognitive deficits in patients and animal models of Alzheimer's disease (AD). The underlying mechanisms, however, remain to be fully elucidated. In the present study, we found that Aβ
Externí odkaz:
https://doaj.org/article/ba2813ffe31f47f08148beb0e2eb4d45
Autor:
Hongyu Pan, Dongpi Wang, Xiaoqin Zhang, Dongming Zhou, Heng Zhang, Qi Qian, Xiao He, Zhaoling Liu, Yunjin Liu, Tingting Zheng, Ling Zhang, Mingkai Wang, Binggui Sun
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 707-718 (2016)
Adult hippocampal neurogenesis was impaired in several Alzheimer's disease models overexpressing mutant human amyloid precursor protein (hAPP). However, the effects of wild-type hAPP on adult neurogenesis and whether the impaired adult hippocampal ne
Externí odkaz:
https://doaj.org/article/d57ffc222fd942e8977010fc872c15de
Autor:
Yaling Hu, Kelei Cao, Fang Wang, Weiying Wu, Weihao Mai, Liyao Qiu, Yuxiang Luo, Woo-ping Ge, Binggui Sun, Ligen Shi, Junming Zhu, Jianmin Zhang, Zhiying Wu, Yicheng Xie, Shumin Duan, Zhihua Gao
Publikováno v:
Nature Metabolism. 4:1756-1774
Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about the metabolic determinants in microglia. By mining large datase