Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Bing K. Jap"'
Solution NMR Approaches for Establishing Specificity of Weak Heterodimerization of Membrane Proteins
Publikováno v:
Journal of the American Chemical Society. 133:20571-20580
Solution NMR provides a powerful approach for detecting complex formation involving weak to moderate intermolecular affinity. However, solution NMR has only rarely been used to detect complex formation between two membrane proteins in model membranes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4754878221c020dd3f0a1f0874739d0e
https://doi.org/10.1021/ja208972h
https://doi.org/10.1021/ja208972h
Publikováno v:
Biochemical and Biophysical Research Communications. 402:291-296
γ-secretase is a membrane protein complex associated with the production of Aβ peptides that are pathogenic in Alzheimer’s disease. We have characterized the activity of γ-secretase complexes under a variety of detergent solubilization and recon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d85d29c613cdbb052835d47bd0853c8
https://doi.org/10.1016/j.bbrc.2010.10.017
https://doi.org/10.1016/j.bbrc.2010.10.017
Publikováno v:
Biochemistry. 46:2553-2563
The gamma-secretase complex is an intramembrane aspartyl protease that cleaves its substrates along their transmembrane regions. Sequential proteolytic processing of amyloid precursor protein by beta- and gamma-secretase produces amyloid beta-peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1334173d851d83e22a66264e31d7a7f7
https://doi.org/10.1021/bi602509c
https://doi.org/10.1021/bi602509c
Publikováno v:
Journal of Molecular Biology. 360:285-296
A double lipid bilayer structure containing opposing tetramers of AQP0 aquaporin, in contact through extracellular face loop regions, was recently modeled using an intermediate-resolution map obtained by electron crystallographic methods. The pores o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bb01b7d59c1c8167d6c18c359fe71a
https://doi.org/10.1016/j.jmb.2006.04.039
https://doi.org/10.1016/j.jmb.2006.04.039
Autor:
Young Do Kwon, Mirjam Beuttler, Bing K. Jap, Carol V. Robinson, Karin Felderer, Michal Sharon, Wolfgang Baumeister, Susanne Witt
Publikováno v:
Structure. 14(7):1179-1188
Summary The processing of propeptides and the maturation of 20S proteasomes require the association of β rings from two half proteasomes. We propose an assembly-dependent activation model in which interactions between helix (H3 and H4) residues of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29848e5310a82584cc761d165814f976
Publikováno v:
Proceedings of the National Academy of Sciences. 102:7499-7504
γ-Secretase is a membrane protein complex that cleaves the β-amyloid precursor protein (APP) within the transmembrane region, after prior processing by β-secretase, producing amyloid β-peptides Aβ 40 and Aβ 42 . Errant production of Aβ-peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a0f4826a58b5a2e149f834be109dfd
https://doi.org/10.1073/pnas.0502768102
https://doi.org/10.1073/pnas.0502768102
Publikováno v:
Journal of Molecular Biology. 335:233-245
To understand the role of the pro-peptide in proteasome assembly, we have determined structures of the Rhodococcus proteasome and a mutant form that prevents the autocatalytic removal of its pro-peptides. The structures reveal that the pro-peptide ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a32faa900c5ec32e4d2e4a93342bc4
https://doi.org/10.1016/j.jmb.2003.08.029
https://doi.org/10.1016/j.jmb.2003.08.029
Publikováno v:
FEBS Letters. 521:24-30
A calmodulin (CaM)-like protein (hCLP) is expressed in human mammary epithelial cells but appears to be limited to certain epithelial cells such as those found in skin, prostate, breast and cervical tissues. A decrease in the expression of this prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0f5d4d8cffe14c903ddf81a8c5bdbb
https://doi.org/10.1016/s0014-5793(02)02780-1
https://doi.org/10.1016/s0014-5793(02)02780-1
Autor:
Peter J. Walian, K G Chandy, Seok-Yong Lee, S Ghanshani, Haixin Sui, C.L Wu, Huilin Li, Bing K. Jap
Publikováno v:
Journal of Molecular Biology. 282:211-216
Potassium channels are integral membrane proteins that play a crucial role in regulating diverse cell functions in both electrically excitable and non-excitable cells. Molecular cloning has revealed a diverse family of genes that encode these protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c495b15be3cb0e3070d74540e43dd09
https://doi.org/10.1006/jmbi.1998.2016
https://doi.org/10.1006/jmbi.1998.2016
Autor:
Kengo Okada, So Iwata, Momi Iwata, Thomas A. Link, Bjarne Rasmussen, Joong W. Lee, John Lee, Bing K. Jap, S. Ramaswamy
Publikováno v:
Science. 281:64-71
Mitochondrial cytochrome bc 1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc 1 complex from bovine heart reveal full vie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a737ae8f48906e87d5fe475fd6bae3c3
https://doi.org/10.1126/science.281.5373.64
https://doi.org/10.1126/science.281.5373.64