Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Binfei Zhou"'
Autor:
Li Zhang, Wenwen Wang, Sun Myoung Kim, Jianjun Wang, Binfei Zhou, Weijia Kong, James Zheng, Xi Lin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/bbea6e328c814c5dbb6723aa1e2c85fa
Autor:
Li Zhang, Wenwen Wang, Sun Myoung Kim, Jianjun Wang, Binfei Zhou, Weijia Kong, James Zheng, Xi Lin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media bet
Externí odkaz:
https://doaj.org/article/c0e54068f0444c78a3ddf9cfb681df98
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4088 (2008)
Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans. Because the mechan
Externí odkaz:
https://doaj.org/article/783e3af1d1eb4928a5bb03020663eb37
Autor:
Jing Wu, Ping Chen, Jingqiao Lu, Feng Xin, Zhu Qingyan, Yongyi Yuan, Zixu Mao, Huijun Yuan, Pu Dai, Xukun Yan, Jianjun Wang, Dongyi Han, Jianguo Zhang, Binfei Zhou, Xi Lin, Jin Zeng, Xue Gao, Shiming Yang, Hui Jiang, Qi Li, Qing Chang, Weiwei Guo
Publikováno v:
Cell Research
De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome
Publikováno v:
The Journal of Gene Medicine. 15:123-133
Background Gene transfer into the inner ear is a promising approach for treating sensorineural hearing loss. The special electrochemical environment of the scala media raises a formidable challenge for effective gene delivery at the same time as keep
Publikováno v:
Biochemical and Biophysical Research Communications. 417:245-250
Mutations in Gjb2 and Gjb6 genes, coding for connexin26 (Cx26) and Cx30 proteins, respectively, are linked to about half of all cases of human autosomal non-syndromic prelingual deafness. Molecular mechanisms of the hearing impairments, however, are
Publikováno v:
EMBO Molecular Medicine
Mutations in the potassium channel subunit KCNQ1 cause the human severe congenital deafness Jervell and Lange-Nielsen (JLN) syndrome. We applied a gene therapy approach in a mouse model of JLN syndrome (Kcnq1 � /� mice) to prevent the development
Publikováno v:
Molecular Cancer Therapeutics. 5:2366-2377
Following surgery, the hormone dependence of breast tumors is exploited for therapy using antagonists such as tamoxifen, although occasional hormone-resistant clones do appear. Another chemotherapeutic strategy uses microtubule inhibitors such as tax
Autor:
Yunfeng, Wang, Yu, Sun, Qing, Chang, Shoeb, Ahmad, Binfei, Zhou, Yeunjung, Kim, Huawei, Li, Xi, Lin
Publikováno v:
The journal of gene medicine. 15(3-4)
Gene transfer into the inner ear is a promising approach for treating sensorineural hearing loss. The special electrochemical environment of the scala media raises a formidable challenge for effective gene delivery at the same time as keeping normal
Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness. To investigate deafness mechanisms underlying Cx26 null mutations, we generated three independent lines of conditional Cx26 null mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6794f9dd64980deff5d0db35547e0af
https://europepmc.org/articles/PMC2713729/
https://europepmc.org/articles/PMC2713729/