Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Bindu Santhamma"'
Autor:
Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang, Prabhakar Pitta Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra Lee Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Zhenming Xu, Brij B. Singh, Philip T. Valente, Yidong Chen, Zhao Lai, Manjeet Rao, Edward R. Kost, Tyler Curiel, Rajeshwar R. Tekmal, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-18 (2024)
Abstract Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The precise m
Externí odkaz:
https://doaj.org/article/9ac36726d5db494b89c1884b726a9b5c
Autor:
Nicole Spencer, Alondra Lee Rodriguez Sanchez, Rahul Gopalam, Panneerdoss Subbarayalu, Daisy M. Medina, Xue Yang, Paulina Ramirez, Lois Randolph, Emily Jean Aller, Bindu Santhamma, Manjeet K. Rao, Rajeshwar Rao Tekmal, Hareesh B. Nair, Edward R. Kost, Ratna K. Vadlamudi, Suryavathi Viswanadhapalli
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17426 (2023)
Endometrial cancer (ECa) is the most common female gynecologic cancer. When comparing the two histological subtypes of endometrial cancer, Type II tumors are biologically more aggressive and have a worse prognosis than Type I tumors. Current treatmen
Externí odkaz:
https://doaj.org/article/64006e65c45b44ea84569a84e639c587
Autor:
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh V. Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Li, Viswanadhapalli et al utilized multiple in vitro, ex vivo and in vivo models of TNBC to investigate LIFR inhibition. The authors reported that HDAC inhibition in TNBC cells led to an increase of LIFR expression and over activation of the downstre
Externí odkaz:
https://doaj.org/article/8b39ff553a7a47e7a5a926087847574b
Autor:
Weiwei Tang, Kumaraguruparan Ramasamy, Sureshkumar M. A. Pillai, Bindu Santhamma, Swapna Konda, Prabhakar Pitta Venkata, Logan Blankenship, Junhao Liu, Zexuan Liu, Kristin A. Altwegg, Behnam Ebrahimi, Uday P. Pratap, Xiaonan Li, Philip T. Valente, Edward Kost, Gangadhara R. Sareddy, Ratna K. Vadlamudi, Hareesh B. Nair, Rajeshwar R. Tekmal, Suryavathi Viswanadhapalli
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Endometrial cancer (EC) is the fourth most common cancer in women. Advanced-stage EC has limited treatment options with a poor prognosis. There is an unmet need for the identification of actionable drivers for the development of targeted the
Externí odkaz:
https://doaj.org/article/1cfca25be46f4749a68da61a6d728416
Autor:
Hareesh B Nair, Bindu Santhamma, Naveen K Krishnegowda, Kalarikkal V Dileep, Klaus J Nickisch
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151182 (2016)
Use of estrogen or estrogen/progestin combination was an approved regimen for menopausal hormonal therapy (MHT). However, more recent patient-centered studies revealed an increase in the incidence of breast cancer in women receiving menopausal hormon
Externí odkaz:
https://doaj.org/article/af532240aaac41fd840aff5c551d9b81
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07cd43c1488eac97dde539175fac68e
https://doi.org/10.1158/1535-7163.c.6538359.v1
https://doi.org/10.1158/1535-7163.c.6538359.v1
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary Figure S1 shows SPR studies and Biotin EC359 pull down assays; Supplementary Figure S2 shows superimposition of hLIFR onto the mLIFR -hLIF complex; Supplementary Figure S3 shows sequence alignment of human (P42702) and mouse (P42703) LI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ee451be075a9d46cb02b1970ab4b84
https://doi.org/10.1158/1535-7163.22506315
https://doi.org/10.1158/1535-7163.22506315
Autor:
Ratna K. Vadlamudi, Klaus J. Nickisch, Hareesh B. Nair, Rajeshwar R. Tekmal, Manjeet K. Rao, Vijaya Manthati, Andrew J. Brenner, Ganesh V. Raj, Marek Bajda, Ramachandran Murali, Xinlei Pan, Kam Y.J. Zhang, Kalarickal V. Dileep, Alejandra Chávez-Riveros, Annabel Chang, Xiaonan Li, Kristin A. Altwegg, Uday P. Pratap, Rajni Sonavane, Shihong Ma, Mengxing Li, Mei Zhou, Bindu Santhamma, Gangadhara R. Sareddy, Yiliao Luo, Suryavathi Viswanadhapalli
Supplementary methods section contain description of synthesis and characterization of EC330 and EC359, SPR studies, structural and sequence comparison of human and mouse LIFR, energy minimization of hLIFR, Protein and ligand preparation, molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f80ccb9927594621014305b0b7429d
https://doi.org/10.1158/1535-7163.22506309.v1
https://doi.org/10.1158/1535-7163.22506309.v1
Supplementary Data from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
Autor:
Ratna K. Vadlamudi, Hariprasad Vankayalapati, Manjeet K. Rao, Tim H.-M. Huang, Stan McHardy, Rajeshwar R. Tekmal, Gangadhara R. Sareddy, Daohong Zhou, Yaxia Yuan, Ganesh V. Raj, Zhao Lai, Yidong Chen, Bindu Santhamma, Ben H. Park, Shihong Ma, Xiaonan Li, John R. Sanchez, Behnam Ebrahimi, Uday P. Pratap, Junhao Liu, Zexuan Liu, Samaya Krishnan, Dimple Chakravarty, Monica Mann, Suryavathi Viswanadhapalli, Kristin A. Altwegg
Supplementary Data from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959d7bbb0ef81c60f20cfbe0f25bc169
https://doi.org/10.1158/0008-5472.22432383
https://doi.org/10.1158/0008-5472.22432383
Autor:
Ratna K. Vadlamudi, Hariprasad Vankayalapati, Manjeet K. Rao, Tim H.-M. Huang, Stan McHardy, Rajeshwar R. Tekmal, Gangadhara R. Sareddy, Daohong Zhou, Yaxia Yuan, Ganesh V. Raj, Zhao Lai, Yidong Chen, Bindu Santhamma, Ben H. Park, Shihong Ma, Xiaonan Li, John R. Sanchez, Behnam Ebrahimi, Uday P. Pratap, Junhao Liu, Zexuan Liu, Samaya Krishnan, Dimple Chakravarty, Monica Mann, Suryavathi Viswanadhapalli, Kristin A. Altwegg
Supplementary Figure from A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d89245a913219976866a2fc67bad0a4
https://doi.org/10.1158/0008-5472.22432380
https://doi.org/10.1158/0008-5472.22432380