Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Bindu D. Paul"'
Autor:
Chiara Lanzillotta, Antonella Tramutola, Simona Lanzillotta, Viviana Greco, Sara Pagnotta, Caterina Sanchini, Silvia Di Angelantonio, Elena Forte, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà, Flavia Agata Cimini, Ilaria Barchetta, Maria Gisella Cavallo, Andrea Urbani, D. Allan Butterfield, Fabio Di Domenico, Bindu D. Paul, Marzia Perluigi, Joao M.N. Duarte, Eugenio Barone
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103221- (2024)
Brain insulin resistance links the failure of energy metabolism with cognitive decline in both type 2 Diabetes Mellitus (T2D) and Alzheimer's disease (AD), although the molecular changes preceding overt brain insulin resistance remain unexplored. Abn
Externí odkaz:
https://doaj.org/article/981f6d63b120410193df144c24aca2cc
Autor:
Bindu D. Paul, Andrew A. Pieper
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 155 (2024)
Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant
Externí odkaz:
https://doaj.org/article/aa9fed934ac7478e99cc957530a5bc5f
Autor:
Richa Tyagi, Suwarna Chakraborty, Sunil Jamuna Tripathi, Ik-Rak Jung, Sangwon F. Kim, Solomon H. Snyder, Bindu D. Paul
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107199- (2023)
Summary: Maintenance of redox balance plays central roles in a plethora of signaling processes. Although physiological levels of reactive oxygen and nitrogen species are crucial for functioning of certain signaling pathways, excessive production of f
Externí odkaz:
https://doaj.org/article/872d7538b9ac4ec9875a5b192c097dbe
Autor:
Yvonne L. Latour, Johanna C. Sierra, Jordan L. Finley, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Thaddeus M. Smith, Kara M. McNamara, Paula B. Luis, Claus Schneider, Justin Jacobse, Jeremy A. Goettel, M. Wade Calcutt, Kristie L. Rose, Kevin L. Schey, Ginger L. Milne, Alberto G. Delgado, M. Blanca Piazuelo, Bindu D. Paul, Solomon H. Snyder, Alain P. Gobert, Keith T. Wilson
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori, which infects half of the world’s population and causes gastric cancer. Recent studies have highlighted the importance of macrophage imm
Externí odkaz:
https://doaj.org/article/19c8a2f445654133870ff2cc83d6103c
Autor:
Bindu D. Paul, Andrew A. Pieper
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1095 (2023)
The gaseous signaling molecule hydrogen sulfide (H2S) critically modulates a plethora of physiological processes across evolutionary boundaries. These include responses to stress and other neuromodulatory effects that are typically dysregulated in ag
Externí odkaz:
https://doaj.org/article/b70ef0d2984f4ef2880aa549cf2b7980
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1154 (2023)
Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive complications, including significantly increased risk of developing aging-related neurodegenerative disease. As advances in neurocritical care increase the number o
Externí odkaz:
https://doaj.org/article/5d4cea956bb64ef4b78a2f8fffc64ba2
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1470 (2022)
Cysteine is a semi-essential amino acid that not only plays an essential role as a component of protein synthesis, but also in the generation of numerous sulfur-containing molecules such as the antioxidant glutathione and coenzyme A. We previously sh
Externí odkaz:
https://doaj.org/article/429bc619186142979048b365f688669c
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100332- (2021)
Summary: Evaluating redox homeostasis involves gauging the levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) directly in tissues and cells. The brain is especially metabolically active and is particularly vulnerable to exces
Externí odkaz:
https://doaj.org/article/00da5ccbf59f4a5aaf526367e3217fea
Publikováno v:
Redox Biology, Vol 38, Iss , Pp 101772- (2021)
Hydrogen sulfide (H2S) was once considered to have only toxic properties, until it was discovered to be an endogenous signaling molecule. The effects of H2S are dose dependent, with lower concentrations being beneficial and higher concentrations, cyt
Externí odkaz:
https://doaj.org/article/cca2935554154cc1b0f6f0f645267a00
Autor:
Bindu D. Paul, Solomon H. Snyder
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms. Thus, there is an urgent need to develop
Externí odkaz:
https://doaj.org/article/7e7b6cd1452d4a40b1352621c0ccb880