Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bindu Chandrasekhar"'
Autor:
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Benter
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132215 (2015)
Cationic polyamidoamine (PAMAM) dendrimers are branch-like spherical polymers being investigated for a variety of applications in nanomedicine including nucleic acid drug delivery. Emerging evidence suggests they exhibit intrinsic biological and toxi
Externí odkaz:
https://doaj.org/article/b91dbb0d9ccc45409a029ce0092c54a9
Autor:
Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Ibrahim F Benter
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141657 (2015)
Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members, namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular dysfunction. Angiotensin-(1-7) [Ang-(1-7)] can prevent the development of
Externí odkaz:
https://doaj.org/article/c133290b35db4e68aa2f3e080bf07c45
Autor:
Saghir Akhtar, Mariam H M Yousif, Gursev S Dhaunsi, Fatma Sarkhouh, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67813 (2013)
Diabetes mellitus leads to vascular complications but the underlying signalling mechanisms are not fully understood. Here, we examined the role of ErbB2 (HER2/Neu), a transmembrane receptor tyrosine kinase of the ErbB/EGFR (epidermal growth factor re
Externí odkaz:
https://doaj.org/article/9828ec605115477086f99b23630bf5c1
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39066 (2012)
This study characterized the effects of diabetes and/or ischemia on epidermal growth factor receptor, EGFR, and/or erbB2 signaling pathways on cardiac function. Isolated heart perfusion model of global ischemia was used to study the effect of chronic
Externí odkaz:
https://doaj.org/article/63c540eb05354aab8496fdad745a5dde
Autor:
Hussa, Alshahwan, Bedoor, Qabazard, Alyaa, Mousa, Bindu, Chandrasekhar, Krishna, Santhosh, Mariam H M, Yousif
Publikováno v:
European Journal of Pharmacology. 933:175265
Hydrogen sulfide (Hthe effects of chronic treatment of diabetic rats with GYY4137 (slow releasing Hdiabetes was induced by a single intraperitoneal (ip) injection of streptozotocin (STZ; 55 mg/kg). Sprague Dawley (SD; n = 10-12/group) rats were rando
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6945457f4929b05781841c759a67b05c
https://doi.org/10.1016/j.ejphar.2022.175265
https://doi.org/10.1016/j.ejphar.2022.175265
Publikováno v:
Diabetes. 69
The underlying mechanisms leading to diabetes-induced vascular complications are not fully understood. We have previously shown that epidermal growth factor receptor (EGFR), which is part of the four membered family of EGFR/ErbB receptor tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b801f239fc6370e20a8562b204d68b06
https://doi.org/10.2337/db20-455-p
https://doi.org/10.2337/db20-455-p
Autor:
Bashayer Al-Zaid, Bindu Chandrasekhar, Saghir Akhtar, Sreeja Attur, Ahmed Z. El-Hashim, Ibrahim F. Benter
Publikováno v:
International Journal of Pharmaceutics. 514:353-363
The in vivo impact of two generation 6 cationic polyamidoamine (PAMAM) dendrimers on cellular signaling via extracellular-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK), as well as their relationship to epidermal gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0bbcb234ffdad8fc6315b19daa73dd
https://doi.org/10.1016/j.ijpharm.2016.03.039
https://doi.org/10.1016/j.ijpharm.2016.03.039
Autor:
Ibrahim F. Benter, Ahmed Z. El-Hashim, Mariam H. M. Yousif, Bindu Chandrasekhar, Waleed M. Renno, Saghir Akhtar
We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor (EGFR)-ERK1/2-Rho kinase (ROCK)-a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd2091d780196f4a9c0837b3ddce6ca
https://hdl.handle.net/10576/11477
https://hdl.handle.net/10576/11477
Publikováno v:
Diabetes. 67
Upregulation of epidermal growth factor receptor (EGFR) signaling is involved in development of diabetes-induced vascular dysfunction. Polyamidoamine (PAMAM) dendrimers (branch-like polymers) might be novel inhibitors of EGFR for they inhibit EGFR ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::717890b332797940eeef4a4917b56c6e
https://doi.org/10.2337/db18-480-p
https://doi.org/10.2337/db18-480-p
Autor:
Sreeja Attur, Bindu Chandrasekhar, Abeer T. Al-Khaldi, Ibrahim F. Benter, Gursev S. Dhaunsi, Fatima Sarkhou, Saghir Akhtar, Mariam H. M. Yousif
Publikováno v:
Journal of Drug Targeting. 23:506-518
The epidermal growth factor receptors, EGFR and EGFR2 (ErbB2), appear important mediators of diabetes-induced vascular dysfunction. We investigated whether targeted dual inhibition of EGFR and ErbB2 with Lapatinib would be effective in treating diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a92b0bbe316ce82d9a310a81d3559e
https://doi.org/10.3109/1061186x.2015.1057150
https://doi.org/10.3109/1061186x.2015.1057150