Astrocyte-secreted neurocan controls inhibitory synapse formation and function

Autor: Irala, Dolores, Wang, Shiyi, Sakers, Kristina, Nagendren, Leykashree, Ulloa Severino, Francesco Paolo, Bindu, Dhanesh Sivadasan, Savage, Justin T., Eroglu, Cagla

Publikováno v: In Neuron 15 May 2024 112(10):1657-1675

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Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation.

Autor: Wang S; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Baumert R; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Séjourné G; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Bindu DS; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Department of Neonatology, Children's Mercy Hospital, Kansas City, MO, USA., Dimond K; College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA., Sakers K; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Vazquez L; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Moore J; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Tan CX; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Takano T; Division of Molecular Systems for Brain Function, Kyushu University Institute for Advanced Study, Medical Institute of Bioregulation, Japan.; Japan Science and Technology Agency, PRESTO, Japan., Rodriguez MP; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Soderling SH; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., La Spada AR; The Department of Neurology, Duke University Medical Center, Durham, NC, USA.; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, CA, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, CA, USA., Eroglu C; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

Autor: Chen X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Wolfe DA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Bindu DS; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA., Zhang M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Taskin N; Allen Institute for Brain Science, Seattle, WA, USA., Goertsen D; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Shay TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Sullivan E; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Huang SF; Department of Neurosurgery, Clinical Neuroscience Center, Zurich University Hospital, University of Zurich, Zurich, Switzerland., Kumar SR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Arokiaraj CM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Plattner V; Sainsbury Wellcome Centre, University College London, London, UK., Campos LJ; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Mich J; Allen Institute for Brain Science, Seattle, WA, USA., Monet D; Allen Institute for Brain Science, Seattle, WA, USA., Ngo V; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Ding X; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA., Omstead V; Allen Institute for Brain Science, Seattle, WA, USA., Weed N; Allen Institute for Brain Science, Seattle, WA, USA., Bishaw Y; Allen Institute for Brain Science, Seattle, WA, USA., Gore B; Allen Institute for Brain Science, Seattle, WA, USA., Lein ES; Allen Institute for Brain Science, Seattle, WA, USA., Akrami A; Sainsbury Wellcome Centre, University College London, London, UK., Miller C; Cortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA., Levi BP; Allen Institute for Brain Science, Seattle, WA, USA., Keller A; Department of Neurosurgery, Clinical Neuroscience Center, Zurich University Hospital, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland., Ting JT; Allen Institute for Brain Science, Seattle, WA, USA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA., Fox AS; Department of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA., Eroglu C; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA., Gradinaru V; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 13. Date of Electronic Publication: 2023 Jan 13.