Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Binding prediction"'
Autor:
Yiyu Hong, Junsu Ha, Jaemin Sim, Chae Jo Lim, Kwang-Seok Oh, Ramakrishnan Chandrasekaran, Bomin Kim, Jieun Choi, Junsu Ko, Woong-Hee Shin, Juyong Lee
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract We introduce an advanced model for predicting protein–ligand interactions. Our approach combines the strengths of graph neural networks with physics-based scoring methods. Existing structure-based machine-learning models for protein–liga
Externí odkaz:
https://doaj.org/article/7e379bec9c5c44859c5da2655445f68a
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Modelling the regulatory mechanisms that determine cell fate, response to external perturbation, and disease state depends on measuring many factors, a task made more difficult by the plasticity of the epigenome. Scanning the genome for the sequence
Externí odkaz:
https://doaj.org/article/496bb8568f2448649dc95139d145780c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Immunotherapy has ushered in a new era of cancer treatment, yet cancer remains a leading cause of global mortality. Among various therapeutic strategies, cancer vaccines have shown promise by activating the immune system to specifically target cancer
Externí odkaz:
https://doaj.org/article/3a07a74712ae482e8efc71c0e1d1c564
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The identification of protein binding residues helps to understand their biological processes as protein function is often defined through ligand binding, such as to other proteins, small molecules, ions, or nucleotides. Methods predicting b
Externí odkaz:
https://doaj.org/article/2b3dcdd6452b40dbbaff9693ba42b48b
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract Cross‐species prediction of TF binding remains a major challenge due to the rapid evolutionary turnover of individual TF binding sites, resulting in cross‐species predictive performance being consistently worse than within‐species perf
Externí odkaz:
https://doaj.org/article/e8e5949bd0dd41db8b4a321930fe9d74
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract For ligand binding prediction, it is crucial for molecular docking programs to integrate template-based modeling with a precise scoring function. Here, we proposed the CoDock-Ligand docking method that combines template-based modeling and th
Externí odkaz:
https://doaj.org/article/ab97bbfcb2914538b9e088f49bb3e638
Publikováno v:
Naučno-tehničeskij Vestnik Informacionnyh Tehnologij, Mehaniki i Optiki, Vol 23, Iss 5, Pp 989-1000 (2023)
Solving the problem of predicting the immune response against foreign protein sequence fragments processed by cells is one of the major milestones on the road to the personalized cancer vaccine development. The selection of peptides participating i
Externí odkaz:
https://doaj.org/article/d7f4674fa6e541f6807ff0e82ac8a0bc
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1097 (2024)
Peanut allergy, a prevalent and potentially severe condition affecting millions worldwide, has been linked to specific human leukocyte antigens (HLAs), suggesting increased susceptibility. Employing an immunoinformatic strategy, we developed a “log
Externí odkaz:
https://doaj.org/article/726d5774db8849caa64568c471c6cd12
Autor:
Yaqing Yang, Zhonghui Wei, Gabriel Cia, Xixi Song, Fabrizio Pucci, Marianne Rooman, Fuzhong Xue, Qingzhen Hou
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Major histocompatibility complex Class II (MHCII) proteins initiate and regulate immune responses by presentation of antigenic peptides to CD4+ T-cells and self-restriction. The interactions between MHCII and peptides determine the specificity of the
Externí odkaz:
https://doaj.org/article/b3e1da7d4a5945d2b7ba5241f41096db
Autor:
Kari Lybeck, Stig Tollefsen, Heidi Mikkelsen, Siri Kulberg Sjurseth, Claus Lundegaard, Claus Aagaard, Ingrid Olsen, Gregers Jungersen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium avium subspecies paratuberculosis (MAP) is a global concern in modern livestock production worldwide. The available vaccines against paratuberculosis do not offer optimal protection and interfere with the diagnosis of bovine tuberculosi
Externí odkaz:
https://doaj.org/article/95f5f3e0bfb641d3999ec4fe58997243