Zobrazeno 1 - 10
of 11 385
pro vyhledávání: '"Binding assay"'
Publikováno v:
BioTechniques, Pp 1-10 (2024)
Avidin-biotin binding, the most robust non-covalent protein-ligand interaction occurring in nature, has wide-ranging applications in biotechnology. A frequent challenge in these applications is accurately determining the number of unoccupied biotin b
Externí odkaz:
https://doaj.org/article/c3a988544e4e41a998d75a6da60b4f19
Autor:
Andrić Deana B., Dukić-Stefanović Slađana, Krunić Mihajlo J., Jevtić Ivana I., Penjišević Jelena Z., Šukalović Vladimir B., Kostić-Rajačić Slađana
Publikováno v:
Journal of the Serbian Chemical Society, Vol 89, Iss 3, Pp 291-303 (2024)
Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most noted as a neurotransmitter, an activator of the utmost subtype family of G-protein- coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors treat central nervous sy
Externí odkaz:
https://doaj.org/article/47afa94e4ac443949c6748901a92f248
Autor:
Ji Youn Lee, Ho Young Kim, Paul Martorano, Aladdin Riad, Michelle Taylor, Robert R. Luedtke, Robert H. Mach
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionDopamine D3 receptor (D3R) ligands have been studied for the possible treatment of neurological and neuropsychiatric disorders. However, selective D3R radioligands for in vitro binding studies have been challenging to identify due to the
Externí odkaz:
https://doaj.org/article/749d70c6f3d64d56a3d27ba12f3a01ef
Autor:
Hossein Fasihi, Elham Rezaee, Mahsa Mehranfar, Mojdeh Safari, Motahareh Sabbagh Bajestani, Soraya Shahhosseini, Mona Khoramjouy, Mehrdad Faizi, Sayyed Abbas Tabatabai
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101411- (2024)
Benzodiazepines (BZD) are widely used in neurological disorders. The use of classical benzodiazepines is limited due to side effects. In this study, based on the structure–activity relationship (SAR) of Benzodiazepine receptors, new derivatives of
Externí odkaz:
https://doaj.org/article/a71fb3b33c9a45308b703fcb1231b375
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Xyleborus affinis, one of the most important pests of rubber trees, has caused severe damage to the natural rubber industry in Hainan province. The ability to detect host plants through a sensitive and specific olfactory system is crucial for Xylebor
Externí odkaz:
https://doaj.org/article/0280fbca52184c03b43e7a9e13ea00ad
Autor:
Masako Osawa, Takurou Akiya, Funa Ogawa, Takao Suzuki, Masaki Yamagami, Tadashi Umemoto, Akira Ideno
Publikováno v:
BioTechniques, Vol 75, Iss 1, Pp 21-30 (2023)
Quantitative bioanalysis is essential when establishing pharmacokinetic properties during the drug development process. To overcome challenges of sensitivity, specificity and process complexity associated with the conventional analysis of antisense o
Externí odkaz:
https://doaj.org/article/c59bd1e7c8ef452f9e11b7123f8f6485
Autor:
Honggang Xiang, Renxiao Wang
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
The autophagy-related 12 (ATG12)–autophagy-related 5 (ATG5)–autophagy-related 16-like 1 (ATG16L1) ternary complex forms a dimer that facilitates the translocation of autophagy-related 8 (ATG8) proteins from autophagy-related 3 (ATG3) to phosphati
Externí odkaz:
https://doaj.org/article/a1fe9862698341739f883e7a32397bf2
Autor:
Elham Rezaee, Fatemeh Ahmadi, Mahsa Shabaninia, Mona Khoramjouy, Zahra Azizi Farsani, Soraya Shahhosseini, Sayyed Abbas Tabatabai, Mehrdad Faizi
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 250-262 (2023)
Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer u
Externí odkaz:
https://doaj.org/article/45301b9ec83443fc83427fbbc0a54c96
Publikováno v:
Journal of Integrative Agriculture, Vol 22, Iss 2, Pp 514-525 (2023)
Chemosensory proteins (CSPs) perform several functions in insects. This study performed the gene expression, ligand-binding, and molecular docking assays on the EforCSP3 identified in the parasitoid wasp Encarsia formosa, to determine whether EforCSP
Externí odkaz:
https://doaj.org/article/e804ab355298432ba23564879e3c3008
Autor:
Ryoko Sasaki, Mary Ann Suico, Keisuke Chosa, Yuriko Teranishi, Takashi Sato, Asuka Kagami, Shunsuke Kotani, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto, Tomohiro Yamashita, Takeshi Yokoyama, Mineyuki Mizuguchi, Hirofumi Kai, Tsuyoshi Shuto
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 1, Pp 54-62 (2023)
Hereditary ATTR amyloidosis is caused by the point mutation in serum protein transthyretin (TTR) that destabilizes its tetrameric structure to dissociate into monomer. The monomers form amyloid fibrils, which are deposited in peripheral nerves and or
Externí odkaz:
https://doaj.org/article/73aa628980de4100b6bdb344612c5194