Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

Autor: Samia M. Mostafa, Ismail Salama, Mohamed Gomaa, Kirsty J. McLean, Mohamed A. Helal, Safaa M. Kishk, Claire Simons, Luiz Pedro S. de Carvalho, Sakshi Sood, Andrew W. Munro

Publikováno v: Bioorganic & Medicinal Chemistry
Kishk, S, Mclean, K, Sood, S, Helal, M, Gomaa, M, Salama, I, Mostafa, S, de Carvalho, L P, Munro, A & Simons, C 2019, ' Synthesis and Biological Evaluation of Novel cYY Analogues targeting Mycobacterium tuberculosis CYP121A1 ', Bioorganic & Medicinal Chemistry, vol. 27, no. 8, doi: 10.1016/j.bmc.2019.02.051, pp. 1546-1561 . https://doi.org/10.1016/j.bmc.2019.02.051

Graphical abstract
The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dab9ab9352bf0f38c06f000a0f7ea9
https://pubmed.ncbi.nlm.nih.gov/30837169

Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues

Autor: Simon M. Ametamey, Sanja Batinac, Silvana Raić-Malić, Gerd Folkers, Erik De Clercq, Leonardo Scapozza, Anass Johayem

Synthesis of pyrimidine derivatives with a side-chain attached to the C-6 of pyrimidine ring (6-14) is reported. Target compounds 8 and 12 were subjected to in vitro phosphorylation tests, determination of their binding affinities to herpes simplex v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaed2184ce72ddc1631cc4083cb1cfc
https://www.bib.irb.hr/149197