Zobrazeno 1 - 10
of 10 607
pro vyhledávání: '"Binding affinity"'
Autor:
Srinivasarao Mande, Lalitha Repudi, Sanchari Goswami, P. Kumar Nallasivan, Kumaraswamy Gandla
Publikováno v:
Bulletin of the National Research Centre, Vol 48, Iss 1, Pp 1-11 (2024)
Abstract Background Breast cancer, one of the most often diagnosed malignancies worldwide, continues to take countless women's lives. Its treatment usually involves targeting the human estrogen receptor alpha (ERα). Current research explores the pot
Externí odkaz:
https://doaj.org/article/c6014e34a1ec4a99bf8b41877700661e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Human herpes viruses (HHV) are ubiquitous and have been implicated in numerous long-term health conditions. Since the association between viral exposure and long-term health impacts is partially influenced by variation in human leukocyte ant
Externí odkaz:
https://doaj.org/article/b490cbc72d5c47d7afc09b416a380d1f
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations occurring in nucleic acids or proteins may affect the binding affinities of protein-nucleic acid interactions. Although many efforts have been devoted to the impact of protein mutations, few computational studies have ad
Externí odkaz:
https://doaj.org/article/228c65b0bb634957af2b56172b1d59ea
Autor:
Yaqi Xu, Xinyao Sui, Jinhong Li, Liyi Zhang, Pengpeng Wang, Yang Liu, Huijing Shi, Yunhui Zhang
Publikováno v:
Eco-Environment & Health, Vol 3, Iss 3, Pp 308-316 (2024)
Per- and polyfluoroalkyl substances (PFAS) can pass through the placenta and adversely affect fetal development. However, there is a lack of comparison of legacy and emerging PFAS levels among different biosamples in pregnant women and their offsprin
Externí odkaz:
https://doaj.org/article/523e6d22aacd4f80939be1675e8df892
Autor:
Marcus Ho-Hin Shum, Yang Lee, Leighton Tam, Hui Xia, Oscar Lung-Wa Chung, Zhihong Guo, Tommy Tsan-Yuk Lam
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 759-770 (2024)
Coronaviruses (CoVs) pose a major risk to global public health due to their ability to infect diverse animal species and potential for emergence in humans. The CoV spike protein mediates viral entry into the cell and plays a crucial role in determini
Externí odkaz:
https://doaj.org/article/1d830b35b6564d84b59bc45186de6796
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 460-472 (2024)
The application of machine learning techniques in biological research, especially when dealing with limited data availability, poses significant challenges. In this study, we leveraged advancements in method development for predicting protein-protein
Externí odkaz:
https://doaj.org/article/ec75bc088f3c43d29f0503f210929d2f
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract In this study, Density-functional theory/Time-dependent density-functional theory (DFT/TDDFT) and Molecular docking method was used to investigate the effect of methyl acetate, tetrahydrofuran and cyanobenzylidene substituents on the electro
Externí odkaz:
https://doaj.org/article/554c32380227470a83880011da4412fd
Publikováno v:
AIMS Neuroscience, Vol 11, Iss 2, Pp 203-211 (2024)
Obsessive-compulsive disorder (OCD) is a chronic psychiatric disease in which patients suffer from obsessions compelling them to engage in specific rituals as a temporary measure to alleviate stress. In this study, deep learning-based methods were us
Externí odkaz:
https://doaj.org/article/5c6a251affc24b5c900935e12fb05141
Publikováno v:
Iranian Journal of Diabetes and Obesity, Vol 16, Iss 2, Pp 112-121 (2024)
Objective: The VEGF function blockage effectively reduces the progression of diabetic retinopathy. Ranibizumab and bevacizumab are some anti-VEGF monoclonal antibodies (mAb). Considering the importance of affinity maturation of ranibizumab, we aimed
Externí odkaz:
https://doaj.org/article/c3fc5cb9246b413ebc225e517821ee2f
Autor:
Debanjan Roy, Gunjan Gayen, Sabnam Ara Begum, Sandip Ghosh, Sucheto Talukder, Arisha Sarkar, Shritama Aich
Publikováno v:
Iranian Journal of Diabetes and Obesity, Vol 16, Iss 2, Pp 122-126 (2024)
Objective: Bullous pemphigoid is a rare autoimmune skin disorder characterized by blistering, urticarial lesions, which are sometimes associated with adverse drug reactions. Vildagliptin is an oral anti-diabetic agent that selectively inhibits the di
Externí odkaz:
https://doaj.org/article/cc6c0267a7224007ba1bbff25b09c15a