Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Binding, Competitive/drug effects"'
Autor:
Simonas Masiulis, Rooma Desai, Tomasz Uchański, Itziar Serna Martin, Duncan Laverty, Dimple Karia, Tomas Malinauskas, Jasenko Zivanov, Els Pardon, Abhay Kotecha, Jan Steyaert, Keith W. Miller, A. Radu Aricescu
Publikováno v:
Nature
Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99ddfc1e90bf2f8c4ef5adae2031142
https://hdl.handle.net/20.500.14017/f9fb4511-ea37-4521-ab26-627d95b587ef
https://hdl.handle.net/20.500.14017/f9fb4511-ea37-4521-ab26-627d95b587ef
Autor:
Philip Seeman, Irina Vitcu, Pablo Rusjan, Romina Mizrahi, David C. Mamo, Shitij Kapur, Ariel Graff-Guerrero, Nathalie Ginovart, Alan A. Wilson, Matthaeus Willeit
Publikováno v:
Hum Brain Mapp
Human Brain Mapping, Vol. 29, No 4 (2008) pp. 400-10
Human Brain Mapping, Vol. 29, No 4 (2008) pp. 400-10
The D(2) receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [(11)C]‐(+)‐PHNO is a PET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32f0ad0e12b49b20efe3f2ed646ada6
https://doi.org/10.1002/hbm.20392
https://doi.org/10.1002/hbm.20392
Autor:
Rossen Radkov, Solange Kharoubi-Hess, Danièle Schaer, Käthi Geering, Jean-Daniel Horisberger, Nikolai N. Modyanov
Publikováno v:
Biochemical and Biophysical Research Communications, vol. 356, no. 1, pp. 142-6
Cardiac steroids inhibit Na,K-ATPase and the related non-gastric H,K-ATPase, while they do not interact with gastric H,K-ATPase. Introducing an arginine, the residue present in the gastric H,K-ATPase, in the second extracellular loop at the correspon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a2ea1f58dda6a4087dd8fa3573114
https://doi.org/10.1016/j.bbrc.2007.02.119
https://doi.org/10.1016/j.bbrc.2007.02.119
Autor:
Elli Leppä, Peer Wulff, Waltraud Ogris, Marco Capogna, Peter Somogyi, H. Hoeger, Esa R. Korpi, Anni-Maija Linden, William Wisden, Werner Sieghart, A. Oberto, C. Halbsguth, Theofanis Karayannis, D. W. Cope, Francesco Ferraguti
Publikováno v:
Cope, D W, Halbsguth, C, Karayannis, T, Wulff, P, Ferraguti, F, Hoeger, H, Leppä, E, Linden, A-M, Oberto, A, Ogris, W, Korpi, E R, Sieghart, W, Somogyi, P, Wisden, W & Capogna, M 2005, ' Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation ', The European journal of neuroscience, vol. 21, no. 11, pp. 3002-16 . https://doi.org/10.1111/j.1460-9568.2005.04127.x
Europe PubMed Central
Europe PubMed Central
Zolpidem is a hypnotic benzodiazepine site agonist with some gamma-aminobutyric acid (GABA)(A) receptor subtype selectivity. Here, we have tested the effects of zolpidem on the hippocampus of gamma2 subunit (gamma2F77I) point mutant mice. Analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a0e4e690a4883f85a630b50b1ff98
https://doi.org/10.1111/j.1460-9568.2005.04127.x
https://doi.org/10.1111/j.1460-9568.2005.04127.x
Autor:
Rustam H. Ziganshin, Daniel Bertrand, Titia K. Sixma, Victor I. Tsetlin, Alexander Fish, Prakash Rucktooa, Alexey V. Osipov, Igor E. Kasheverov, Alexey Yu. Khruschov, Maxim N. Zhmak, August B. Smit, Dieter D’hoedt
Publikováno v:
Journal of Neurochemistry, Vol. 111, No 4 (2009) pp. 934-44
Kasheverov, I E, Zhmak, M N, Fish, A, Rucktooa, P, Khruschov, A Y, Osipov, A V, Ziganshin, R H, D'Hoedt, D, Bertrand, D, Sixma, T K, Smit, A B & Tsetlin, V I 2009, ' Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor ', Journal of Neurochemistry, vol. 111, pp. 934-944 . https://doi.org/10.1111/j.1471-4159.2009.06359.x
Journal of Neurochemistry, 111, 934-944. Wiley-Blackwell
Kasheverov, I E, Zhmak, M N, Fish, A, Rucktooa, P, Khruschov, A Y, Osipov, A V, Ziganshin, R H, D'Hoedt, D, Bertrand, D, Sixma, T K, Smit, A B & Tsetlin, V I 2009, ' Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor ', Journal of Neurochemistry, vol. 111, pp. 934-944 . https://doi.org/10.1111/j.1471-4159.2009.06359.x
Journal of Neurochemistry, 111, 934-944. Wiley-Blackwell
alpha-Conotoxins interact with nicotinic acetylcholine receptors (nAChRs) and acetylcholine-binding proteins (AChBPs) at the sites for agonists/competitive antagonists. alpha-Conotoxins blocking muscle-type or alpha7 nAChRs compete with alpha-bungaro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4088b7e0e780a119be9debdb83db1a9
https://archive-ouverte.unige.ch/unige:5107
https://archive-ouverte.unige.ch/unige:5107
Publikováno v:
European Journal of Neuroscience, Vol. 26, No 9 (2007) pp. 2633-2642
The lateral septal area is rich in vasopressin V(1A) receptors and is densely innervated by vasopressinergic axons, originating mainly from the bed nucleus of the stria terminalis and the amygdala. Genetic and behavioral studies provide evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a94f0ccf270dd766f7797b0f55626a6d
https://pubmed.ncbi.nlm.nih.gov/17970727
https://pubmed.ncbi.nlm.nih.gov/17970727
Autor:
Antoniou, K., Galanopoulos, A., Vlachou, S., Kourouli, T., Nahmias, V., Thermos, K., Panagis, G., Daifoti, Z., Marselos, M., Papahatjis, D., Spyraki, C.
Newly developed cannabinoids may hold the promise of the development of useful and safe drugs. This study aimed to investigate the behavioral effects of the novel 1',1'-dithiolane delta8-HC analogue AMG-3, a cannabinomimetic molecule with high affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::5402306520c48997d1c15e36b305c594
http://olympias.lib.uoi.gr/jspui/handle/123456789/23524
http://olympias.lib.uoi.gr/jspui/handle/123456789/23524
Autor:
Fabrizio Bordi, Marco Mor, Mirko Rivara, Vigilio Ballabeni, Elisabetta Barocelli, Simona Bertoni, Valentina Zuliani, Federica Vacondio, Pierre-Alain Carrupt, Silvia Rivara, Bernard Testa, Francesca Magnanini, Claudia Silva, Pier Vincenzo Plazzi
Publikováno v:
European Journal of Pharmaceutical Sciences, Vol. 23, No 1 (2004) pp. 89-98
H3-antagonists possess promising pharmacological effects on awakening, learning and memory, but few data on their access to the central nervous system (CNS) have been reported so far. The purpose of this work was to investigate the relationships betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ef7428a7cc596e4255405314482dd9
https://archive-ouverte.unige.ch/unige:10671
https://archive-ouverte.unige.ch/unige:10671
Publikováno v:
J. Neurochemistry, 82(2), 430-438. Blackwell Publishing Ltd
Journal of Neurochemistry, 82(2), 430-438. Blackwell Publishing Ltd
Journal of Neurochemistry, 82(2), 430-438. Blackwell Publishing Ltd
The binding characteristics of [(125) I]insulin-like growth factor (IGF)-I were studied in human brain and pituitary gland. Competition binding studies with DES(1-3)IGF-I and R-3 -IGF-I, which display high affinity for the IGF-I receptor and low affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d1780843f5997678f513b20e6e131361
https://research.rug.nl/en/publications/35e69d8f-cec3-45c9-be2e-c0a1c81930be
https://research.rug.nl/en/publications/35e69d8f-cec3-45c9-be2e-c0a1c81930be
The articles comprising this volume were first presented at the World Congress on Neurohypophysial Hormones held in Bordeaux, France on September 8-12, 2001. This conference brought together more than 170 scientists from 18 countries who belong to th