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Akademický článek

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

Autor: Diarmaid J. Murphy, Yahya H. Dallal Bashi, Clare F. McCoy, Peter Boyd, Leeanne Brown, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Bríd Devlin, R. Karl Malcolm

Publikováno v: International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100112- (2022)

We have previously reported a multipurpose silicone elastomer vaginal ring providing sustained release of dapivirine (an antiretroviral) and levonorgestrel (a progestin) for HIV prevention and hormonal contraception. During initial development, issue

Externí odkaz: https://doaj.org/article/98d3571e295347d6bdcf8ce0b2fa4992

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Akademický článek

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

Autor: Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck, R. Karl Malcolm

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100081- (2021)

Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human immunodeficiency virus (HIV) transmission via vaginal sex. Following Phase I trials, significant

Externí odkaz: https://doaj.org/article/33201504c4cc4078bdec85999ffab7fe

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Akademický článek

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

Autor: Yahya H. Dallal Bashi, Diarmaid J. Murphy, Clare F. McCoy, Peter Boyd, Leeanne Brown, Matthew Kihara, François Martin, Nicole McMullen, Kyle Kleinbeck, Bindi Dangi, Patrick Spence, Bashir Hansraj, Brid Devlin, R. Karl Malcolm

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100091- (2021)

A dapivirine-releasing silicone elastomer vaginal ring for reducing women's risk of HIV acquisition has recently been approved. A next-generation multipurpose vaginal ring releasing dapivirine and levonorgestrel is currently in development, offering

Externí odkaz: https://doaj.org/article/b7f3a5a85e75423d8f768cfe40fff198

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Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

Autor: Bashir Hansraj, Patrick Spence, Diarmaid J. Murphy, Brid Devlin, Kyle Kleinbeck, R. Karl Malcolm, Bindi Dangi, Peter Boyd, Matthew Kihara, Clare McCoy, Nicole McMullen, Leeanne Brown, Yahya H. Dallal Bashi, Francois Martin

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100091-(2021)
International Journal of Pharmaceutics: X
Dallal Bashi, Y H, Murphy, D J, McCoy, C F, Boyd, P, Brown, L, Kihara, M, Martin, F, McMullen, N, Kleinbeck, K, Dangi, B, Spence, P, Hansraj, B, Devlin, B & Malcolm, R K 2021, ' Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel ', International Journal of Pharmaceutics: X, vol. 3, 100091 . https://doi.org/10.1016/j.ijpx.2021.100091

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de38dbedfa67eab5fc840a0342ea6e47
https://doi.org/10.1016/j.ijpx.2021.100091

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Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis

Autor: J. Paul Zimmer, Julie M. Nauroth, Ying Chun Liu, Norman Salem, Melissa V. Olson, Bindi Dangi

Publikováno v: Inflammation Research. 62:1003-1013

This study was designed to determine the anti-inflammatory activity of docosahexaenoic acid (DHA), alone and in combination with eicosapentaenoic acid (EPA), in a murine model of rheumatoid arthritis, collagen induced arthritis (CIA). The CIA was ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87bb5b9e5361a2577f954c4849d117e
https://doi.org/10.1007/s00011-013-0658-4

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Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis

Autor: Bindi Dangi, Martin Purschke, Maik Schroeder, Dieter Manstein, Cordula Dierkes, Beate Gomolka, Karsten H. Weylandt, Nora R. Huang, Cheng-Ying Chiu

Publikováno v: Inflammation Research. 61:967-976

Enzymatically oxygenated lipid products derived from omega-3 and omega-6 fatty acids play an important role in inflammation dampening. This study examined the anti-inflammatory effects of n-6 docosapentaenoic acid-derived (17S)-hydroxy-docosapentaeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046ab4030937de6bebaefe4595c7711d
https://doi.org/10.1007/s00011-012-0489-8

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Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6)

Autor: Marcus Obeng, Gloria Chung, Eileen Bailey-Hall, Linda M. Arterburn, Todd Hallenbeck, Julie M. Nauroth, Bindi Dangi

Publikováno v: Biochemical Pharmacology. 79:251-260

17S-HDPAn-6 (17S-hydroxydocosa-4Z,7Z,10Z,13Z,15E-pentaenoic acid) and 10S,17S-HDPAn-6 (10S,17S-dihydroxydocosa-4Z,7Z,11E,13Z,15E-pentaenoic acid) are potent anti-inflammatory resolvins derived from DPAn-6 (docosapentaenoic acid n-6) and are analogous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e239afe0ae82b7772a4f4c0faea7926
https://doi.org/10.1016/j.bcp.2009.08.001

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Biogenic Synthesis, Purification, and Chemical Characterization of Anti-inflammatory Resolvins Derived from Docosapentaenoic Acid (DPAn-6)

Autor: Linda M. Arterburn, Micah Hazzy Needham, Bindi Dangi, Marcus Obeng, Julie M. Nauroth, Krishna Raman, Mah Teymourlouei

Publikováno v: Journal of Biological Chemistry. 284:14744-14759

Enzymatically oxygenated derivatives of the ω-3 fatty acids cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) and cis-5,8,11,14,17-eicosapentaenoic acid, known as resolvins, have potent inflammation resolution activity (Serhan, C. N., Clish, C. B., Bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1352a5c32588d26e6b089908c0647c
https://doi.org/10.1074/jbc.m809014200

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Solution Structure and Dynamics of the Human−Escherichia coli Thioredoxin Chimera: Insights into Thermodynamic Stability

Autor: Bindi Dangi, John M. Louis, Angela M. Gronenborn, Anatoliy Dobrodumov

Publikováno v: Biochemistry. 41:9376-9388

We have determined the high-resolution solution structure of the oxidized form of a chimeric human and Escherichia coli thioredoxin (TRX(HE)) by NMR. The overall structure is well-defined with a rms difference for the backbone atoms of 0.27 +/- 0.06

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7020eeece630c1c9b7393ec6c6d1c5c1
https://doi.org/10.1021/bi0258501

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Posttranscriptional Activation of the Transcriptional Activator Rob by Dipyridyl in Escherichia coli

Autor: Robert G. Martin, Judah L. Rosner, Bindi Dangi, Angela M. Gronenborn

Publikováno v: Journal of Bacteriology. 184:1407-1416

The transcriptional activator Rob consists of an N-terminal domain (NTD) of 120 amino acids responsible for DNA binding and promoter activation and a C-terminal domain (CTD) of 169 amino acids of unknown function. Although several thousand molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d203840b1b72c6051842c789a1f22a
https://doi.org/10.1128/jb.184.5.1407-1416.2002

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