Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Bindhu, Karanam"'
Autor:
Andrew J, Kassick, Jinlong, Jiang, Jaime, Bunda, David, Wilson, Jianming, Bao, Huagang, Lu, Peter, Lin, Richard G, Ball, George A, Doss, Xinchun, Tong, Kwei-Lan C, Tsao, Hong, Wang, Gary, Chicchi, Bindhu, Karanam, Richard, Tschirret-Guth, Koppara, Samuel, Donald F, Hora, Sanjeev, Kumar, Maria, Madeira, Waisi, Eng, Richard, Hargreaves, Mona, Purcell, Liza, Gantert, Jacquelyn, Cook, Robert J, DeVita, Sander G, Mills
Publikováno v:
Journal of medicinal chemistry. 56(14)
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba
Autor:
Jinqi, Liu, Judith N, Gorski, Stephen J, Gold, Dunlu, Chen, Shirley, Chen, Gail, Forrest, Yoshiki, Itoh, Donald J, Marsh, David G, McLaren, Zhu, Shen, Lisa, Sonatore, Ester, Carballo-Jane, Stephanie, Craw, Xiaoming, Guan, Bindhu, Karanam, Junichi, Sakaki, Daphne, Szeto, Xinchun, Tong, Jianying, Xiao, Ryo, Yoshimoto, Hong, Yu, Thomas P, Roddy, James, Balkovec, Shirly, Pinto
Publikováno v:
Obesity (Silver Spring, Md.). 21(7)
Investigation was conducted to understand the mechanism of action of diacylglycerol acyltransferase 1 (DGAT1) using small molecules DGAT1 inhibitors, compounds K and L.Biochemical and stable-label tracer approaches were applied to interrogate the fun