Zobrazeno 1 - 10
of 57
pro vyhledávání: '"BinQing, Wei"'
Autor:
Gail D. Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu, Carter T. Fields, Genee Lee, Donglu Zhang, Peter S. Dragovich, Thomas Pillow, BinQing Wei, Jack Sadowsky, Douglas Leipold, Tim Wilson, Amrita Kamath, Michael Mamounas, M. Violet Lee, Ola Saad, Voleak Choeurng, Alexander Ungewickell, Sharareh Monemi, Lisa Crocker, Kevin Kalinsky, Shanu Modi, Kyung Hae Jung, Erika Hamilton, Patricia LoRusso, Ian Krop, Melissa M. Schutten, Renee Commerford, Mark X. Sliwkowski, Eunpi Cho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan. To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzuma
Externí odkaz:
https://doaj.org/article/654b41b090ea4a87be21fb42ec554dae
Autor:
Gail Lewis Phillips, Guangmin Li, Jun Guo, Shang-Fan Yu, Genee Lee, Donglu Zhang, Peter Dragovich, Thomas Pillow, Binqing Wei, M. Violet Lee, Ola Saad, Shab Masih, Douglas Leipold, Lisa Crocker, Melissa Schutten
Publikováno v:
Cancer Research. 82:P2-13
Background: Many HER2-directed antibody-drug conjugates (ADCs) in early development employ trastuzumab linked to tubulin binding agents as the cytotoxic drug. DHES0815A is an ADC consisting of a THIOMABTM humanized IgG1 anti-HER2 monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d3a641b3e31f1f2c5dfe53879c377e
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-33
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-33
Autor:
Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11f71008647153e48985266e826374
https://doi.org/10.1021/acsmedchemlett.1c00473
https://doi.org/10.1021/acsmedchemlett.1c00473
Autor:
Gail Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu, Carter Fields, Genee Lee, Donglu Zhang, Peter Dragovich, Thomas Pillow, BinQing Wei, Jack Sadowsky, Timothy Wilson, Michael Mamounas, M Violet Lee, Ola Saad, Voleak Choeurng, Alexander Ungewickell, Shararah Monemi, Lisa Crocker, Kevin Kalinsky, Shanu Modi, Kyung-Hae Jung, Erika Hamilton, Patricia LoRusso, Ian Krop, Melissa Schutten, Renee Commerford, Mark Sliwkowski, Eunpi Cho, Douglas leipold
Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan. To develop a novel HER2 ADC, we selected an antibody that does not compete with trastuzumab or pertuzumab for binding,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99124dcde0d6f94bd769d813e20dfcab
https://doi.org/10.21203/rs.3.rs-2322502/v1
https://doi.org/10.21203/rs.3.rs-2322502/v1
Autor:
Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne
Publikováno v:
Journal of Medicinal Chemistry. 64:2534-2575
The biological and medicinal impacts of proteolysis-targeting chimeras (PROTACs) and related chimeric molecules that effect intracellular degradation of target proteins via ubiquitin ligase-mediated ubiquitination continue to grow. However, these chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1
https://doi.org/10.1021/acs.jmedchem.0c01845
https://doi.org/10.1021/acs.jmedchem.0c01845
Autor:
BinQing Wei, Kirk Robarge, Sharada S. Labadie, Jinhua Chen, Laura B. Corson, Antonio DiPasquale, Peter S. Dragovich, Charles Eigenbrot, Marie Evangelista, Benjamin P. Fauber, Anna Hitz, Rebecca Hong, Kwong Wah Lai, Wenfeng Liu, Shuguang Ma, Shiva Malek, Thomas O'Brien, Jodie Pang, David Peterson, Laurent Salphati, Deepak Sampath, Steven Sideris, Mark Ultsch, Zijin Xu, Ivana Yen, Dong Yu, Qin Yue, Aihe Zhou, Hans E. Purkey
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
Structure-based design was utilized to optimize 6,6-diaryl substituted dihydropyrone and hydroxylactam to obtain inhibitors of lactate dehydrogenase (LDH) with low nanomolar biochemical and single-digit micromolar cellular potencies. Surprisingly the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0770db4a66cefb70bb9bee4bcf37ca52
https://pubmed.ncbi.nlm.nih.gov/35065235
https://pubmed.ncbi.nlm.nih.gov/35065235
Autor:
Donglu Zhang, Binqing Wei, Jun Guo, Thomas H. Pillow, Buyun Chen, Chenghong Zhang, Leanna Staben, Dewakar Sangaraju, Gail Lewis Phillips, Dian Su, Yong Ma, Cyrus Khojasteh, Sudheer Bobba, Jianshuang Wang, Peter S. Dragovich, Shuai Wang
Publikováno v:
Drug Metabolism and Disposition. 47:547-555
Duocarmycins [including cyclopropyl pyrroloindole (CPI) or cyclopropyl benzoindole (CBI)] are a class of DNA minor-groove alkylators and seco-CPI/CBIs are synthetic pro-forms that can spirocyclize to CPI/CBI. Bis-CPI/CBIs are potential drug candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e255053fc710a12d6fc9d091e76faf
https://doi.org/10.1124/dmd.118.085209
https://doi.org/10.1124/dmd.118.085209
Autor:
Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei
Publikováno v:
Journal of medicinal chemistry. 64(5)
Heterobifunctional compounds that direct the ubiquitination of intracellular proteins in a targeted manner via co-opted ubiquitin ligases have enormous potential to transform the field of medicinal chemistry. These chimeric molecules, often termed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518e
https://pubmed.ncbi.nlm.nih.gov/33596073
https://pubmed.ncbi.nlm.nih.gov/33596073
Autor:
Peter S. Dragovich, Jun Guo, Josefa dela Cruz-Chuh, Guangmin Li, Binqing Wei, Zijin Xu, Leanna Staben, Geoff Del Rosario, Shang-Fan Yu, Thomas H. Pillow, Katherine R. Kozak, Mary Ann Go, Jinhua Chen, Rebecca K. Rowntree, John S. Wai, Carl Ng, Keyang Xu, Donglu Zhang, S. Cyrus Khojasteh, Gail Lewis Phillips
Publikováno v:
Journal of medicinal chemistry. 63(17)
Cytotoxic pyrrolobenzodiazepine (PBD)-dimer molecules are frequently utilized as payloads for antibody-drug conjugates (ADCs), and many examples are currently in clinical development. In order to further explore this ADC payload class, the physicoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f05642a14801d439bd63d27f4c631bb
https://pubmed.ncbi.nlm.nih.gov/32787101
https://pubmed.ncbi.nlm.nih.gov/32787101
Autor:
Leanna Staben, Josefa dela Cruz-Chuh, Hoa Le, Thomas H. Pillow, Binqing Wei, Dian Su, Peter S. Dragovich, Breanna S. Vollmar, Peter W. Fan, S. Cyrus Khojasteh, Gail Lewis Phillips, Yong Ma, Richard Vandlen, Cornelis E. C. A. Hop, Sudheer Bobba, Chenghong Zhang, Jun Guo, Donglu Zhang, Jack Sadowsky, Katherine R. Kozak
Publikováno v:
Bioconjugate Chemistry. 29:267-274
The valine-citrulline (Val-Cit) dipeptide and p-aminobenzyl (PAB) spacer have been commonly used as a cleavable self-immolating linker in ADC design including in the clinically approved ADC, brentuximab vedotin (Adcetris). When the same linker was us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa602fd575a49e02dae4f0df0c8480b
https://doi.org/10.1021/acs.bioconjchem.7b00576
https://doi.org/10.1021/acs.bioconjchem.7b00576