Výsledky vyhledávání

Lithium, a Common Drug for Bipolar Disorder Treatment, Regulates Amyloid-β Precursor Protein Processing

Autor: Feng Liu, Steven M. Paul, John Ryder, Xin Wu, Yuan Su, Baolin Li, Pat Solenberg, Niles Fox, Kellie A. Brune, Binhui Ni, Yan Zhou

Publikováno v: Biochemistry. 43:6899-6908

Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Although the underlying mechanism(s) of this mood stabilizer remains controversial, recent evidence linking lithium to neurotrophic/neuroprotective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eb1c12633dbd5667b4e618c82d537c
https://doi.org/10.1021/bi035627j

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Neurotensin negatively modulates Akt activity in neurotensin receptor-1-transfected AV12 cells

Autor: Binhui Ni, Melvyn Baez, Feng Liu, Peiyi Yang

Publikováno v: Journal of Cellular Biochemistry. 92:603-611

Neurotensin (NT) regulates a variety of biological processes primarily through interaction with neurotensin receptor-1 (NTR1), a heterotrimeric G-protein-coupled receptor (GPCR). Stimulation of NTR1 has been linked to activation of multiple signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec521c46364bea1c4a142cbf79fa1e8
https://doi.org/10.1002/jcb.20098

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Divergent roles of GSK3 and CDK5 in APP processing

Autor: Yuan Su, Yan Zhou, Binhui Ni, Baolin Li, John Ryder, Feng Liu

Publikováno v: Biochemical and Biophysical Research Communications. 312:922-929

Glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinase 5 (CDK5) are related serine/threonine kinases that have been well studied for their role in tau hyperphosphorylation, however, little is known about their significance in APP processing. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd5beb47378bcbde92bb3ba31515457
https://doi.org/10.1016/j.bbrc.2003.11.014

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Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751

Autor: Feng Liu, Baolin Li, Binhui Ni, Yuan Su

Publikováno v: Experimental Cell Research. 287:387-396

The increased intracellular levels and aberrant processing of the amyloid precursor protein (APP) are associated with beta-amyloid peptide (A beta) production, cerebrovascular amyloid deposition, and amyloid plaque formation. Here we report that APP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7691bbd99ef9e13fc843a91fce733a45
https://doi.org/10.1016/s0014-4827(03)00152-6

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Molecular Cloning, Expression, and Chromosomal Localization of a Human Brain-Specific Na+-Dependent Inorganic Phosphate Cotransporter

Autor: Steven M. Paul, Paul Robert Rosteck, Yansheng Du, Xin Wu, Binhui Ni, Bradley S. DeHoff

Publikováno v: Journal of Neurochemistry. 66:2227-2238

We describe the molecular cloning of a cDNA encoding a human brain Na(+)-dependent inorganic phosphate (P(i)) cotransporter (hBNPI). The nucleotide and deduced amino acid sequences of hBNPI reveal a protein of 560 amino acids with six to eight putati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe4559422d0bc8e6b9ec2cf37a7dc76
https://doi.org/10.1046/j.1471-4159.1996.66062227.x

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α2-Macroglobulin as a β-Amyloid Peptide-Binding Plasma Protein

Autor: Paul A. Hyslop, Steven M. Paul, Zhiyuan Zhang, Kelly R. Bales, Richard C. Dodel, Michele Glinn, Binhui Ni, Yansheng Du

Publikováno v: Journal of Neurochemistry. 69:299-305

The beta-amyloid peptide (A beta) is a normal proteolytic processing product of the amyloid precursor protein, which is constitutively expressed by many, if not most, cells. For reasons that are still unclear, A beta is deposited in an aggregated fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4eda4d48508a07710cdc5c86267b1160
https://doi.org/10.1046/j.1471-4159.1997.69010299.x

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Regional Distribution, Ontogeny, Purification, and Characterization of the Ca2+-Independent Phospholipase A2 from Rat Brain

Autor: Edward A. Dennis, Hsiu-Chiung Yang, Marian Mosior, Binhui Ni

Publikováno v: Journal of Neurochemistry. 73:1278-1287

We purified an 80-kDa Ca 2+ -independent phospholipase A 2 (iPLA 2 ) from rat brain using octyl-Sepharose, ATP-agarose, and calmodulin-agarose column chromatography steps. This procedure gave a 30,000-fold purification and yielded 4 μg of a near-hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc25e1529fa268f94af79348985de061
https://doi.org/10.1046/j.1471-4159.1999.0731278.x

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Selective deposition of amyloid-? protein in the entorhinal-dentate projection of a transgenic mouse model of alzheimer's disease

Autor: Binhui Ni, Yuan Su

Publikováno v: Journal of Neuroscience Research. 53:177-186

Early and selective deposition of amyloid beta protein(Abeta) is thought to be a pathological feature central to Alzheimer's disease (AD). It has been a great challenge to identify the mechanism(s) responsible for the selectivity of Abeta deposition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6323961658718a5ec431a4112f60a8a5
https://doi.org/10.1002/(sici)1097-4547(19980715)53:2<177::aid-jnr6>3.0.co

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