Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Bin-Hai Kuang"'
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 10, Pp o2006-o2006 (2008)
In the title compound, C20H17ClN4O2S, the dihedral angle between the two benzene rings is 65.9 (1)°; the corresponding angle between the 4-chlorophenyl and thiadiazole rings is 3.4 (8)°. The conformations of the N—H and C=O bonds are anti with re
Externí odkaz:
https://doaj.org/article/814f4eb067f246b08662a32a6fa08b89
Publikováno v:
International Journal of Pharmacology. 11:920-928
A B S T R A C T The MIFs was applied to a data set of 40 N-phenylhomophthalimide derivatives of APN inhibitors to generate the 3D-QSAR model at various 3D grid spacing. The cross-validated correlation coefficient q 2 LMO (0.6204) and r 2 pred (0.9810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66a8a891e6e341709ea75b7b5d1317e
https://doi.org/10.3923/ijp.2015.920.928
https://doi.org/10.3923/ijp.2015.920.928
Publikováno v:
Medicinal Chemistry. 11:764-770
The 3D-QSARs models of 29 flavone-8-acetic acid derivatives of aminopeptidase N inhibitors were generated by applying the molecular interaction fields at various 3D grid spacing. The cross-validated correlation coefficient q 2 LMO (0.6019) and conven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e37853826a1301264bbca911247ecd
https://doi.org/10.2174/1573406411666150714111256
https://doi.org/10.2174/1573406411666150714111256
Publikováno v:
Medicinal Chemistry. 10:376-381
Diels-Alder reaction between furan and maleic anhydride resulted in 5,6-dehydro norcantharidin, then norcantharidin was obtained by reduction. The substituted-carboxylic acid was condensed with N-aminothiourea in presence of phosphorus oxychloride, y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68c699fddf9f9f34250552a943b7f46
https://doi.org/10.2174/15734064113099990037
https://doi.org/10.2174/15734064113099990037
Publikováno v:
Journal of molecular modeling. 22(10)
Aminopeptidase N (APN) is a zinc-dependent ectopeptidase involved in cell proliferation, secretion, invasion, and angiogenesis, and is widely recognized as an important cancer target. However, the mechanisms whereby ligands leave the active site of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31346a86692e40d71c364c2c0f0f9d68
https://pubmed.ncbi.nlm.nih.gov/27624165
https://pubmed.ncbi.nlm.nih.gov/27624165
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 26:222-230
The CB1 receptor belongs to the G-protein-coupled receptor superfamily. CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. In this study, we report the synthesis and in vitro binding affinity assay of some 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d9be85e93dbe5cd3058c81460e1935
https://doi.org/10.3109/14756366.2010.491794
https://doi.org/10.3109/14756366.2010.491794
Autor:
Bin-Hai Kuang, Fang Xiong, Gang Li, Guo-Gang Tu, Xi Mai, Shao-Hua Li, Wenfang Xu, Huawei Zhu, Hui-Ming Huang
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6663-6668
The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfe0d6669dedd02b2c3bfca57202d5f
https://doi.org/10.1016/j.bmc.2008.05.081
https://doi.org/10.1016/j.bmc.2008.05.081
Autor:
Shao-Hua, Li, Gang, Li, Hui-Ming, Huang, Fang, Xiong, Xi, Mai, Bin-Hai, Kuang, Cheng-Mei, Liu, Guo-Gang, Tu
Publikováno v:
Die Pharmazie. 64(2)
Aminopeptidase N (APN) is a zinc-dependent ectopeptidase which plays an important role in the invasion of metastatic tumors. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49c462f1ce223593bd06632f67f9bce2
https://pubmed.ncbi.nlm.nih.gov/19320275
https://pubmed.ncbi.nlm.nih.gov/19320275
Publikováno v:
Zeitschrift für Kristallographie-New Crystal Structures, Vol 227, Iss 3, Pp 375-376 (2012)
C14H13NO6 ,h exagonal, P62 (no. 171), a =1 0.085(1) A, c =1 1.677(2) A,V =1 028.5 A 3 , Z =3 , R gt (F) =0 .0504, wRref(F 2 ) =0 .1386, T =2 98 K. Source of material Aniline (0.9 3g ,0 .0 1m ol) was added dropwise to as olution of dihydro-3,4-bis-(ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f599d1ec9ddb3550b0ce53c3d7368744
https://doaj.org/article/3c3a1568b3bf48268897fdea9633847e
https://doaj.org/article/3c3a1568b3bf48268897fdea9633847e
Autor:
Cheng-Mei Liu, Shi-Yuan Luo, Shao-Hua Li, Hui-Ming Huang, Guo-Gang Tu, Bin-Hai Kuang, Fang Xiong
Publikováno v:
Zeitschrift für Kristallographie-New Crystal Structures, Vol 224, Iss 2, Pp 201-202 (2009)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669a11eeb83498f973b7767fd97632a2
https://doaj.org/article/37f54a9d686247d38206be17659681a2
https://doaj.org/article/37f54a9d686247d38206be17659681a2