Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Bin-Bing S. Zhou"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered. In this study, an MTX-
Externí odkaz:
https://doaj.org/article/c2af4a4018994ca9a8533fc34c6e6f4b
Autor:
Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Publikováno v:
Blood Science, Vol 5, Iss 1, Pp 39-50 (2023)
Tumor relapse is the major cause of treatment failure in childhood acute lymphoblastic leukemia (ALL), yet the underlying mechanisms are still elusive. Here, we demonstrate that phosphoribosyl pyrophosphate synthetase 2 (PRPS2) mutations drive ALL re
Externí odkaz:
https://doaj.org/article/98b98f79a4104f64b0f67302fa87b235
Autor:
Yan Xu, Houshun Fang, Yao Chen, Yabin Tang, Huiying Sun, Ziqing Kong, Fan Yang, Renate Kirschner-Schwabe, Liang Zhu, Alex Toker, Ning Xiao, Bin-Bing S. Zhou, Hui Li
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103881- (2022)
Summary: Mutations in RAS pathway genes are highly prevalent in acute lymphoblastic leukemia (ALL). However, the effects of RAS mutations on ALL cell growth have not been experimentally characterized, and effective RAS-targeting therapies are being s
Externí odkaz:
https://doaj.org/article/40e05a2d452446e8a0089403384e9b42
Autor:
Chao Tang, Ming-Hao Li, Ya-Li Chen, Hui-Ying Sun, Sheng-Li Liu, Wei-Wei Zheng, Meng-Yi Zhang, Hui Li, Wei Fu, Wen-Jun Zhang, Ai-Bin Liang, Zhong-Hua Tang, Deng-Li Hong, Bin-Bing S. Zhou, Cai-Wen Duan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-14 (2018)
Abstract Background Considerable efforts have been devoted toward the uncovering of the molecular mechanisms underlying the maintenance of hematopoietic stem cells (HSCs) by the normal bone marrow (BM) niche. Previously, we demonstrated that a chemot
Externí odkaz:
https://doaj.org/article/cb81d3acaec643adb29517fd2771d6aa
Autor:
Lili Song, Peifeng Li, Huiying Sun, Lixia Ding, Jing Wang, Benshang Li, Bin-Bing S. Zhou, Haizhong Feng, Yanxin Li
Publikováno v:
Blood Science. 5:39-50
Autor:
Ji-Yuan Teng, Ding-Peng Yang, Chao Tang, Hou-Shun Fang, Hui-Ying Sun, Yue-Ning Xiang, Xiao-Meng Li, Fan Yang, Rui-Xue Xia, Fu Fan, Jingjing Liu, Jiyang Yu, Jin-Chuan Hu, Ben-Shang Li, Hui Li, Fei-Long Meng, Cai-Wen Duan, Bin-Bing S. Zhou
Publikováno v:
Leukemia.
Autor:
Bin-Bing S. Zhou, Ignacio I. Wistuba, Robert T. Abraham, Erwin R. Boghaert, Lioudmila Tchistiakova, Kimberly Marquette, Kiran Khandke, Douglas Armellino, Deborah Evans, Philip R. Hamann, Arthur Kunz, Maureen Dougher, Latha Sridharan, Janet Gruzas, Carol Rios, Sung E. Choe, Carmen Behrens, Veronica Diesl, Shuguang Huang, Maha Karnoub, John F. DiJoseph, Jonathon Golas, Michelle Baxter, Ping Yuan, Maximillian T. Follettie, Kenneth G. Geles, Marc Damelin
Supplementary Figures 1-6, Tables 1-5, Methods from Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186952fe8cbb4a85ba21bc2960b81f6a
https://doi.org/10.1158/0008-5472.22387940.v1
https://doi.org/10.1158/0008-5472.22387940.v1
Autor:
Lijuan Du, Pandurang Kolekar, Jiaoyang Cai, Jeffery M. Klco, Houshun Fang, Xiaotu Ma, Bin-Bing S. Zhou, Omkar Pathak, Huiying Sun, Samuel W. Brady, Hong-Zhuan Chen, Yu Liu, Benshang Li, Hui Li, Xiaomeng Li, Lixia Ding, Cornelia Eckert, Renate Kirschner-Schwabe, Malwine J. Barz, Shuhong Shen, Jinghui Zhang, Cai-Wen Duan, Fan Yang, Chao Tang, Arend von Stackelberg, Yao Chen, Tianyi Wang
Publikováno v:
Nature Cancer. 2:819-834
Chemotherapy is a standard treatment for pediatric acute lymphoblastic leukemia (ALL), which sometimes relapses with chemoresistant features. However, whether acquired drug-resistance mutations in relapsed ALL pre-exist or are induced by treatment re
Publikováno v:
Genome Instability & Disease. 1:301-309
Cancer cells evolve throughout disease progression and tumor relapse. Such evolution is a dynamic process resulting in genotypic and phenotypic cellular changes, conferring a high level of cell plasticity. Data derived from next-generation sequencing
Autor:
Jie Zhao, Ke Xu, Fan Yang, Ludmil B. Alexandrov, Edgar Sioson, Cheng Cheng, Samuel W. Brady, Shuhong Shen, Lele Sun, Liqing Tian, Benshang Li, Heather L. Mulder, Tianyi Wang, Yu Liu, Diane Flasch, James R. Downing, Ting Nien Lin, Xiaofan Zhu, Hui Zhang, Lijuan Du, Ching-Hon Pui, Matthew A. Myers, Yongjin Li, Ningling Wang, Michael Rusch, Karol Szlachta, Xiaotu Ma, Liu Yang, Jingyan Tang, Bin-Bing S. Zhou, Xin Zhou, Benjamin J. Raphael, Jinghui Zhang, Hui Li, Hui Ying Sun, Lixia Ding, Li Dong, Ying Shao, Jiaoyang Cai, Jingliao Zhang, Yingchi Zhang, Hongye Sun, Michael N. Edmonson, Kohei Hagiwara, John Easton, Yanling Liu, Jun J. Yang
Publikováno v:
Blood
To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alteration