Zobrazeno 1 - 10
of 951
pro vyhledávání: '"Bin SHAO"'
Autor:
Bin Shao, Jiawei Yan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Inspired by the success of large language models (LLMs), we develop a long-context generative model for genomes. Our multiscale transformer model, megaDNA, is pre-trained on unannotated bacteriophage genomes with nucleotide-level tokenizatio
Externí odkaz:
https://doaj.org/article/ee84320e97d64542b1c2d28b9af3a99e
Autor:
Yue Zhang, Xiao-Jing Liu, Xin-Ran Zhai, Yao Yao, Bin Shao, Yu-Han Zhen, Xin Zhang, Zhe Xiao, Li-Fang Wang, Ming-Lian Zhang, Zhi-Min Chen
Publikováno v:
International Journal of Ophthalmology, Vol 17, Iss 8, Pp 1403-1410 (2024)
AIM: To investigate the effects of fibrillin-1 (FBN1) deletion on the integrity of retina-blood barrier function and the apoptosis of vascular endothelial cells under diabetic conditions. METHODS: Streptozotocin (STZ)-induced diabetic mice were used
Externí odkaz:
https://doaj.org/article/13b7fd72c9084c90b45e94ab0247aecf
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Objective Investigating the early biomechanical effects of the one-hole split endoscope (OSE) technique on lumbar spine after decompression surgery. Methods A retrospective analysis was conducted on 66 patients with lumbar spinal stenosis (L
Externí odkaz:
https://doaj.org/article/c1f4c02c93954500bd6606e6b70a724f
Autor:
Xinyi Zhou, Xiaoyu Yang, Shenzhen Huang, Guifeng Lin, Kexin Lei, Qian Wang, Weimin Lin, Hanwen Li, Xingying Qi, Dutmanee Seriwatanachai, Shengyong Yang, Bin Shao, Quan Yuan
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract N6‐methyladenosine (m6A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role in oral mucosal immunity remains ambiguous. Periodontitis is a special but prevalent infectious di
Externí odkaz:
https://doaj.org/article/1c744283f4ca4743899140915f62d8ef
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Translation elongation is essential for maintaining cellular proteostasis, and alterations in the translational landscape are associated with a range of diseases. Ribosome profiling allows detailed measurements of translation at the genome s
Externí odkaz:
https://doaj.org/article/4a19ce39273348e8a8e77454bb363d00
Autor:
Ge Song, Minghui Li, Shumin Fan, Mengmeng Qin, Bin Shao, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He, Qiang Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 836-853 (2024)
Conventional chemotherapy based on cytotoxic drugs is facing tough challenges recently following the advances of monoclonal antibodies and molecularly targeted drugs. It is critical to inspire new potential to remodel the value of this classical ther
Externí odkaz:
https://doaj.org/article/6bdd5bd49e0a4a4693082e385c63c1af
Publikováno v:
IEEE Access, Vol 12, Pp 176728-176738 (2024)
One of the primary concerns in the design and practical use of fully integrated switched capacitor (SC) DC-DC converters is their load-dependent output voltage ripple. In this paper, an all-digital control technique to reduce the output ripple of ful
Externí odkaz:
https://doaj.org/article/1cf383edb15c42e1b485e23eb0dcdd1f
Autor:
Yusong Wang, Tong Wang, Shaoning Li, Xinheng He, Mingyu Li, Zun Wang, Nanning Zheng, Bin Shao, Tie-Yan Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Geometric deep learning has been revolutionizing the molecular modeling field. Despite the state-of-the-art neural network models are approaching ab initio accuracy for molecular property prediction, their applications, such as drug discover
Externí odkaz:
https://doaj.org/article/71536d430cfd44f18d739029f207ec11
Publikováno v:
Symmetry, Vol 16, Iss 11, p 1536 (2024)
The efficiency of rock excavation depends on cut blasting. However, medium-deep hole cutting blasting faces the challenges of large clamping action and unsatisfactory blasting efficiency. The study proposes sectional charge cutting blasting technolog
Externí odkaz:
https://doaj.org/article/289f04ba86f140ba9b6f0ca8a8839d8b
Autor:
Hanfang Jiang, Jianxin Zhong, Jing Wang, Guohong Song, Lijun Di, Bin Shao, Ruyan Zhang, Yaxin Liu, Anjie Zhu, Nan Wang, Huiping Li
Publikováno v:
Cancer Medicine, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract Background Cyclin‐dependent kinase (CDK) 4/6 inhibitor plus endocrine therapy (ET) become standard‐of‐care for patients with hormone receptor‐positive, human epidermal growth factor receptor‐2 negative (HR+/HER2−) metastatic brea
Externí odkaz:
https://doaj.org/article/2ce3716600334395a7d32beb2fb0348e