Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bin N. Zhao"'
Autor:
Kathleen M C Sullivan, Marta Vilalta, Linda S Ertl, Yu Wang, Carolyn Dunlap, Karen Ebsworth, Bin N Zhao, Shijie Li, Yibin Zeng, Zhenhua Miao, Pingchen Fan, Venkat Mali, Christopher Lange, Darren McMurtrie, Ju Yang, Rebecca Lui, Ryan Scamp, Vicky Chhina, Alice Kumamoto, Simon Yau, Ton Dang, Ashton Easterday, Shirley Liu, Shichang Miao, Israel Charo, Thomas J Schall, Penglie Zhang
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286724 (2023)
The interaction of PD-L1 with PD-1 is a major immune checkpoint that limits effector T cell function against cancer cells; monoclonal antibodies that block this pathway have been approved in multiple tumor indications. As a next generation therapy, s
Externí odkaz:
https://doaj.org/article/a53419583b96441186b367f58673ff4f
Autor:
Thomas J. Schall, Israel F. Charo, Irina Kufareva, Rajinder Singh, Bin N. Zhao, Mcmahon Jeffrey P, James Campbell, Yu Wang, Yibin Zeng, Tracy M. Handel, Antoni Krasinski, Catherina L. Salanga, Linda S. Ertl, Ton Dang, Simon Yau, Penglie Zhang
Publikováno v:
J Immunol
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 12
Journal of immunology (Baltimore, Md. : 1950), vol 203, iss 12
C-C chemokine receptor 2 (CCR2) is a key driver of monocyte/macrophage trafficking to sites of inflammation and has long been considered a target for intervention in autoimmune disease. However, systemic administration of CCR2 antagonists is associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36536b2af35fa17dd5dcf55d60a4f339
https://europepmc.org/articles/PMC7028331/
https://europepmc.org/articles/PMC7028331/
Autor:
Bin N. Zhao1, Campbell, James J.1 jcampbell@ChemoCentryx.com, Salanga, Catherina L.2, Ertl, Linda S.1, Yu Wang1, Yau, Simon1, Ton Dang1, Yibin Zeng1, McMahon, Jeffrey P.1, Krasinski, Antoni1, Zhang, Penglie1, Kufareva, Irina2, Handel, Tracy M.2, Charo, Israel F.1, Singh, Rajinder1, Schall, Thomas J.1
Publikováno v:
Journal of Immunology. 12/15/2019, Vol. 203 Issue 12, p3157-3165. 9p.
Autor:
Yu Wang, Zheng Wei, Juan C. Jaen, Trageen Baumgart, Linda S. Ertl, Robert D. Berahovich, Ruiping Zhao, Daniel J. Dairaghi, Jay P. Powers, Antoni Krasinski, Timothy J. Sullivan, Solomon Ungashe, Chia-Lin Tsou, Thomas J. Schall, Andrew M. K. Pennell, Zhenhua Miao, Israel F. Charo, Bin N. Zhao, Landin Boring, Lisa Seitz
Publikováno v:
American journal of physiology. Renal physiology. 305(9)
Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The novel CCR2 antagonist CCX140-B, which is currently in two separate phase 2 clinical trials in diabetic nephropathy, has recently been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a479a469f2d8832cd050d0daa8ccbd72
https://pubmed.ncbi.nlm.nih.gov/23986513
https://pubmed.ncbi.nlm.nih.gov/23986513
Autor:
Juan C. Jaen, Yu Wang, Trageen Baumgart, Robert D. Berahovich, Daniel J. Dairaghi, Jay P. Powers, Antoni Krasinski, Timothy J. Sullivan, Linda S. Ertl, Zhenhua Miao, Matthew J. Walters, Thomas J. Schall, Lisa Seitz, Bin N. Zhao
Publikováno v:
Metabolism: clinical and experimental. 62(11)
Objective CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects. These results support the thesis that insulin resistance and Type 2 diabetes (T2D) are associated with chronic unresolved inflammation. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783f377f1c174082a1990232a96067db
https://pubmed.ncbi.nlm.nih.gov/23953944
https://pubmed.ncbi.nlm.nih.gov/23953944
Autor:
Linda S. Ertl, Solomon Ungashe, Juan C. Jaen, Landin Boring, Antoni Krasinski, Thomas J. Schall, Robert D. Berahovich, Dan Johnson, Yu Wang, Zheng Wei, Daniel J. Dairaghi, Israel F. Charo, Trageen Baumgart, Timothy J. Sullivan, Lisa Seitz, Bin N. Zhao, Chia-Lin Tsou, Pirow Bekker, Andrew M. K. Pennell, Zhenhua Miao, Shichang Miao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics.
The following manuscript was published as a Fast Forward article on February 29, 2012: Sullivan TJ, Dairaghi DJ, Krasinski A, Miao Z, Wang Y, Zhao BN, Baumgart T, Berahovich R, Ertl LS, Pennell A, Seitz L, Miao S, Ungashe S, Wei Z, Johnson D, Boring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eba273e79919da8328026a9e61951f
https://doi.org/10.1124/jpet.111.190918
https://doi.org/10.1124/jpet.111.190918
Autor:
Pirow Bekker, Thomas J. Schall, Emily Wendt, Juan C. Jaen, Matthew J. Walters, Trageen Baumgart, Satish Keshav, Nu Lai, Bin N. Zhao, Andrew M. K. Pennell, Yu Wang, Zheng Wei, Linda S. Ertl, Daniel J. Dairaghi, Solomon Ungashe, J. J. Kim Wright, Mark E. T. Penfold
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 335(1)
The chemokine system represents a diverse group of G protein-coupled receptors responsible for orchestrating cell recruitment under both homeostatic and inflammatory conditions. Chemokine receptor 9 (CCR9) is a chemokine receptor known to be central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c669087925f998ee5392707d9d1776
https://pubmed.ncbi.nlm.nih.gov/20660125
https://pubmed.ncbi.nlm.nih.gov/20660125