Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Bimal N. Desai"'
Autor:
Michael S. Schappe, Marta E. Stremska, Gregory W. Busey, Taylor K. Downs, Philip V. Seegren, Suresh K. Mendu, Zachary Flegal, Catherine A. Doyle, Eric J. Stipes, Bimal N. Desai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Efficient removal of apoptotic cells by phagocytosis underlies tissue development, wound repair, host defense and organ homeostasis. Here, authors identify TRPM7 as a regulator of cargo acidification and Ca2+ signaling during apoptotic cell clearance
Externí odkaz:
https://doaj.org/article/91b4d7f5e2564ec69283f69be2f00ae0
Autor:
Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that invo
Externí odkaz:
https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a21
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/859a309be79849488b8e83c2c9870dc1
Autor:
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101130- (2021)
Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling pro
Externí odkaz:
https://doaj.org/article/3bac5da2881d485a8632564ecf041a48
Autor:
Bénédicte F. Py, Mingzhi Jin, Bimal N. Desai, Anirudh Penumaka, Hong Zhu, Maike Kober, Alexander Dietrich, Marta M. Lipinski, Thomas Henry, David E. Clapham, Junying Yuan
Publikováno v:
Cell Reports, Vol 6, Iss 6, Pp 1122-1128 (2014)
Caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1β (IL-1β) secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of
Externí odkaz:
https://doaj.org/article/b44a020f82154fb5b96661a67e2a8b58
Autor:
Scott Yeudall, Clint M. Upchurch, Philip V. Seegren, Caitlin M. Pavelec, Jan Greulich, Michael C. Lemke, Thurl E. Harris, Bimal N. Desai, Kyle L. Hoehn, Norbert Leitinger
Publikováno v:
Science Advances. 8
Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are deficient in both ACC isoforms in myeloid cells. ACC deficiency altered the lipidomic, tra
Autor:
Ulrike Lorenz, Shih Yi Guo, Christopher B. Medina, Yu-Hsin Chiu, Adishesh K. Narahari, Bimal N. Desai, Douglas A. Bayliss, Hong-Yu Gao, Elizabeth C. Gonye, Catherine A. Doyle, Joanna K. Sandilos, Mahmut Parlak, Thomas P. Conrads, Ming-Ming Zhou, Kodi S. Ravichandran
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Activation of Pannexin 1 (PANX1) ion channels causes release of intercellular signaling molecules in a variety of (patho)physiological contexts. PANX1 can be activated by G protein-coupled receptors (GPCRs), including α1-adrenergic receptors (α1-AR
Autor:
Renata Polanowska-Grabowska, Srabani Sahu, Norbert Leitinger, Noriko Inada, Alexandra Kadl, Subramanian Senthivinayagam, Nathaniel P. Oberholtzer, Kevin W. Aylor, Susanna R. Keller, Ulrike M. Lorenz, Bimal N. Desai, Seichii Uchiyama, Vlad Serbulea, Thurl E. Harris, Limor Steinberg, Bijoy Kundu, Prathiba Jayaguru, Clint M Upchurch, Suresh K. Mendu, Akshaya K. Meher, Mahendra D. Chordia
Publikováno v:
Molecular Metabolism, Vol 44, Iss, Pp 101130-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling prot
Autor:
Suresh K. Mendu, Marta E. Stremska, Bimal N. Desai, Julia K. Krupa, Clare A. Parker, Michael S. Schappe, Eric J. Stipes, Jason S. Rogers, Justin S. A. Perry, Emily K. Moser, Thomas J. Braciale
Publikováno v:
Sci Signal
The thymic development of regulatory T (T(reg)) cells, crucial suppressors of the responses of effector T (T(eff)) cells, is governed by the transcription factor FOXP3. Despite the clinical importance of T(reg) cells, there is a dearth of druggable m
Autor:
Mina Farah, Sean R Cuddy, Parijat Kundu, Chris Boutell, Philip V. Seegren, Austin R Schinlever, Anna R. Cliffe, Taylor K Downs, Sara Dochnal, Jon B. Suzich, Bimal N. Desai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2012f87b5503d8c76eeca70098c8414e
https://doi.org/10.7554/elife.58037.sa2
https://doi.org/10.7554/elife.58037.sa2