Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Bimal K. Chakrabarti"'
Autor:
Sweety Samal, Supratik Das, Saikat Boliar, Huma Qureshi, Tripti Shrivastava, Naresh Kumar, Sandeep Goswami, Manish Bansal, Bimal K. Chakrabarti
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-19 (2018)
Abstract Background HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The cleaved, native, trimeric form of Envs expose only broadly neutral
Externí odkaz:
https://doaj.org/article/9c2ce722125a482ea4665992252727bf
Autor:
Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005674 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005537.].
Externí odkaz:
https://doaj.org/article/4f9b5b6249ed447c9465f827ff4d945d
Autor:
Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer
Publikováno v:
PLoS Pathogens, Vol 12, Iss 4, p e1005537 (2016)
The simian immunodeficiency virus (SIV) challenge model of lentiviral infection is often used as a model to human immunodeficiency virus type 1 (HIV-1) for studying vaccine mediated and immune correlates of protection. However, knowledge of the struc
Externí odkaz:
https://doaj.org/article/edf0f1ad3b9441d5921afba32fbea940
Autor:
Saikat Boliar, Supratik Das, Manish Bansal, Brihaspati N Shukla, Shilpa Patil, Tripti Shrivastava, Sweety Samal, Sandeep Goswami, C Richter King, Jayanta Bhattacharya, Bimal K Chakrabarti
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122443 (2015)
An ideal HIV-1 Env immunogen is expected to mimic the native trimeric conformation for inducing broadly neutralizing antibody responses. The native conformation is dependent on efficient cleavage of HIV-1 Env. The clade B isolate, JRFL Env is efficie
Externí odkaz:
https://doaj.org/article/1d54ec1ad0de47b3880e836e02483af1
Autor:
Tripti Shrivastava, Saikat Boliar, Huma Qureshi, Sweety Samal, Manish Bansal, Bimal K. Chakrabarti, Naresh Kumar, Supratik Das, Sandeep Goswami
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-19 (2018)
Retrovirology
Retrovirology
Background HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The cleaved, native, trimeric form of Envs expose only broadly neutralizing ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdebf8f7a6c467f2ef1b2bd37ac7076
http://link.springer.com/article/10.1186/s12977-018-0431-4
http://link.springer.com/article/10.1186/s12977-018-0431-4
Autor:
Naresh Kumar, Ashish Tyagi, Andrew B. Ward, Sandeep Goswami, Gabriel Ozorowski, Sweety Samal, Tripti Shrivastava, Bimal K. Chakrabarti
Publikováno v:
Vaccine. 36:1627-1636
Using HIV-1 envelope protein (Env)-based immunogens that closely mimic the conformation of functional HIV-1 Envs and represent the isolates prevalent in relevant geographical region is considered a rational approach towards developing HIV vaccine. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4baccef431bdb97f71b5461e4aec4cd
https://doi.org/10.1016/j.vaccine.2018.01.081
https://doi.org/10.1016/j.vaccine.2018.01.081
Autor:
Barna Dey, Krisha Svehla, Ling Xu, Dianne Wycuff, Tongqing Zhou, Gerald Voss, Adhuna Phogat, Bimal K Chakrabarti, Yuxing Li, George Shaw, Peter D Kwong, Gary J Nabel, John R Mascola, Richard T Wyatt
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000445 (2009)
The human immunodeficiency virus type 1 (HIV-1) exterior envelope glycoprotein, gp120, possesses conserved binding sites for interaction with the primary virus receptor, CD4, and also for the co-receptor, generally CCR5. Although gp120 is a major tar
Externí odkaz:
https://doaj.org/article/07b4d6d270fb4f999075317d8ad2a3b4
Autor:
Shilpa Patil, Saikat Boliar, Suprit Deshpande, Dimiter S. Dimitrov, Richard T. Wyatt, Bimal K. Chakrabarti, Brihaspati N. Shukla, Javier Guenaga, Ali Ghobbeh, Weizao Chen
Publikováno v:
Virology. 519
HIV-1 virus entry into target cells requires the envelope glycoprotein (Env) to first bind the primary receptor, CD4 and subsequently the co-receptor. Antibody access to the co-receptor binding site (CoRbs) in the pre-receptor-engaged state, prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054cac7c41e3f36010db862d2d5e0c14
https://pubmed.ncbi.nlm.nih.gov/29684630
https://pubmed.ncbi.nlm.nih.gov/29684630
Autor:
Brihaspati N. Shukla, Saikat Boliar, Tripti Shrivastava, Sandeep Goswami, Manish Bansal, Sweety Samal, Supratik Das, Shubbir Ahmed, Bimal K. Chakrabarti
Publikováno v:
Virology. 510
Efficient cleavage of HIV-1 Env gp160 into its constituent subunits correlates with selective binding to neutralizing antibodies and are the closest mimetic of native, functional Envs. This was first demonstrated with the clade B Env, JRFL. The corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e273d18eaf13591a326f6a32487435dd
https://pubmed.ncbi.nlm.nih.gov/28689085
https://pubmed.ncbi.nlm.nih.gov/28689085
Autor:
Nicole A. Doria-Rose, Sijy O'Dell, Richard Wilson, Carl-Magnus Hogerkorp, Mario Roederer, Mark K. Louder, John R. Mascola, Nancy S. Longo, Christian Poulsen, Bimal K. Chakrabarti, Javier Guenaga, Stephen D. Schmidt, Mark Connors, Yuxing Li, Richard T. Wyatt, Xueling Wu
Publikováno v:
Journal of Virology. 86:11231-11241
The gp120 CD4 binding site (CD4bs) and coreceptor binding site (CoRbs) are two functionally conserved elements of the HIV-1 envelope glycoproteins (Env). We previously defined the presence of CD4bs-neutralizing antibodies in the serum of an HIV-1-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef6c3aef144111ffdd84d7d03cd50b8
https://doi.org/10.1128/jvi.01543-12
https://doi.org/10.1128/jvi.01543-12