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Automated Generation of Novel Fragments Using Screening Data, a Dual SMILES Autoencoder, Transfer Learning and Syntax Correction.

Autor: Bilsland AE; Beatson Drug Discovery Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U.K., McAulay K; Beatson Drug Discovery Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U.K., West R; Beatson Drug Discovery Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U.K., Pugliese A; Beatson Drug Discovery Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U.K.; BioAscent Discovery Ltd., Bo'Ness Road, Newhouse, Lanarkshire ML1 5UH, U.K., Bower J; Beatson Drug Discovery Unit, Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, U.K.

Publikováno v: Journal of chemical information and modeling [J Chem Inf Model] 2021 Jun 28; Vol. 61 (6), pp. 2547-2559. Date of Electronic Publication: 2021 May 24.

A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.

Autor: Cairney CJ; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Godwin LS; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom., Bilsland AE; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Burns S; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Stevenson KH; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., McGarry L; RNAi Screening Facility, Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Revie J; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Moore JD; Horizon Discovery Ltd, Cambridge Research Park, Waterbeach, Cambridge, United Kingdom., Wiggins CM; Horizon Discovery Ltd, Cambridge Research Park, Waterbeach, Cambridge, United Kingdom., Collinson RS; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom., Mudd C; Horizon Discovery Ltd, Cambridge Research Park, Waterbeach, Cambridge, United Kingdom., Tsonou E; Horizon Discovery Ltd, Cambridge Research Park, Waterbeach, Cambridge, United Kingdom., Sadaie M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Bennett DC; Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, United Kingdom., Narita M; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom., Torrance CJ; PhoreMost Ltd, Baraham Research Campus, Cambridge, United Kingdom., Keith WN; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2017 Aug 14; Vol. 13 (8), pp. e1006942. Date of Electronic Publication: 2017 Aug 14 (Print Publication: 2017).

Cancer prevention and therapy through the modulation of the tumor microenvironment.

Autor: Casey SC; Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA, United States., Amedei A; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Aquilano K; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy., Azmi AS; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, United States., Benencia F; Department of Biomedical Sciences, Ohio University, Athens, OH, United States., Bhakta D; School of Chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India., Bilsland AE; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Boosani CS; Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, United States., Chen S; Ovarian and Prostate Cancer Research Laboratory, Guildford, Surrey, United Kingdom., Ciriolo MR; Department of Biology, University of Rome 'Tor Vergata', Rome, Italy., Crawford S; Department of Biology, Southern Connecticut State University, New Haven, CT, United States., Fujii H; Department of Orthopedic Surgery, Nara Medical University, Kashihara, Japan., Georgakilas AG; Physics Department, School of Applied Mathematics and Physical Sciences, National Technical University of Athens, Athens, Greece., Guha G; School of Chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India., Halicka D; New York Medical College, Valhalla, NY, United States., Helferich WG; University of Illinois at Urbana-Champaign, Champaign-Urbana, IL, United States., Heneberg P; Charles University in Prague, Third Faculty of Medicine, Prague, Czech Republic., Honoki K; Department of Orthopedic Surgery, Nara Medical University, Kashihara, Japan., Keith WN; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Kerkar SP; Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States., Mohammed SI; Department of Comparative Pathobiology, Purdue University Center for Cancer Research, West Lafayette, IN, United States., Niccolai E; University of Florence, Florence, Italy., Nowsheen S; Medical Scientist Training Program, Mayo Graduate School, Mayo Medical School, Mayo Clinic, Rochester, MN, United States., Vasantha Rupasinghe HP; Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, Nova Scotia, Canada., Samadi A; Sanus Biosciences, San Diego, United States., Singh N; Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh, India., Talib WH; Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman, Jordan., Venkateswaran V; Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Whelan RL; Mount Sinai Roosevelt Hospital, Icahn Mount Sinai School of Medicine, New York City, NY, United States., Yang X; University of Illinois at Urbana-Champaign, Champaign-Urbana, IL, United States., Felsher DW; Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: dfelsher@stanford.edu.

Publikováno v: Seminars in cancer biology [Semin Cancer Biol] 2015 Dec; Vol. 35 Suppl, pp. S199-S223. Date of Electronic Publication: 2015 Apr 10.