Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Billy W Newton"'
Autor:
Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankel
Publikováno v:
eLife, Vol 7 (2018)
The HIV-1 Tat protein hijacks P-TEFb kinase to activate paused RNA polymerase II (RNAP II) at the viral promoter. Tat binds additional host factors, but it is unclear how they regulate RNAP II elongation. Here, we identify the cytoplasmic ubiquitin l
Externí odkaz:
https://doaj.org/article/4861f751eab349dcb5a30cc8610f90bd
Autor:
Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
Publikováno v:
eLife, Vol 4 (2015)
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response phosphorylate eIF2 serine-51, inhibiting nucleotide exchange by eIF2B. ISRIB, a potent drug-like smal
Externí odkaz:
https://doaj.org/article/12e8ad8456444891baa5b27de57a8417
Autor:
Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun-Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A. P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using aff
Externí odkaz:
https://doaj.org/article/6403bbe7a8b6480aacd27d46627e36f2
Autor:
Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 12, Pp 3931-3944 (2018)
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling casca
Externí odkaz:
https://doaj.org/article/de2f24e8cce94c43a4850912c342577e
Autor:
Nilanjana Chatterjee, Evangelos Pazarentzos, Manasi K. Mayekar, Philippe Gui, David V. Allegakoen, Gorjan Hrustanovic, Victor Olivas, Luping Lin, Erik Verschueren, Jeffrey R. Johnson, Matan Hofree, Jenny J. Yan, Billy W. Newton, John V. Dollen, Charles H. Earnshaw, Jennifer Flanagan, Elton Chan, Saurabh Asthana, Trey Ideker, Wei Wu, Junji Suzuki, Benjamin A. Barad, Yuriy Kirichok, James S. Fraser, William A. Weiss, Nevan J. Krogan, Asmin Tulpule, Amit J. Sabnis, Trever G. Bivona
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2317-2330.e8 (2019)
Summary: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene
Externí odkaz:
https://doaj.org/article/83f131016a464f1dbca868c93b137b5a
Autor:
Joshua R. Kane, David J. Stanley, Judd F. Hultquist, Jeffrey R. Johnson, Nicole Mietrach, Jennifer M. Binning, Stefán R. Jónsson, Sarah Barelier, Billy W. Newton, Tasha L. Johnson, Kathleen E. Franks-Skiba, Ming Li, William L. Brown, Hörður I. Gunnarsson, Adalbjorg Adalbjornsdóttir, James S. Fraser, Reuben S. Harris, Valgerður Andrésdóttir, John D. Gross, Nevan J. Krogan
Publikováno v:
Cell Reports, Vol 11, Iss 8, Pp 1236-1250 (2015)
HIV-1 encodes the accessory protein Vif, which hijacks a host Cullin-RING ubiquitin ligase (CRL) complex as well as the non-canonical cofactor CBFβ, to antagonize APOBEC3 antiviral proteins. Non-canonical cofactor recruitment to CRL complexes by vir
Externí odkaz:
https://doaj.org/article/32dad078585f4d2fb8b9087c87103840
Autor:
Zeynep Cakir, Samuel J. Lord, Yuan Zhou, Gwendolyn M. Jang, Benjamin J. Polacco, Manon Eckhardt, David Jimenez-Morales, Billy W. Newton, Adam L. Orr, Jeffrey R. Johnson, Alexandre da Cruz, R. Dyche Mullins, Nevan J. Krogan, Robert W. Mahley, Danielle L. Swaney
Publikováno v:
Molecular & cellular proteomics : MCP, vol 22, iss 5
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647c091248c059db9dbcf0b93760d397
https://doi.org/10.1101/2022.06.06.495052
https://doi.org/10.1101/2022.06.06.495052
Autor:
Jeffrey R. Johnson, David C. Crosby, Judd F. Hultquist, Andrew P. Kurland, Prithy Adhikary, Donna Li, John Marlett, Justine Swann, Ruth Hüttenhain, Erik Verschueren, Tasha L. Johnson, Billy W. Newton, Michael Shales, Viviana A. Simon, Pedro Beltrao, Alan D. Frankel, Alexander Marson, Jeffery S. Cox, Oliver I. Fregoso, John A.T. Young, Nevan J. Krogan
Publikováno v:
Cell reports, vol 39, iss 2
Cell Reports, 39 (2)
Cell Reports, 39 (2)
Viruses must effectively remodel host cellular pathways to replicate and evade immune defenses, and they must do so with limited genomic coding capacity. Targeting post-translational modification (PTM) pathways provides a mechanism by which viruses c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6761189536151f78dc8ad100c5fe511
Autor:
Matan Hofree, Yuriy Kirichok, Trey Ideker, Amit J. Sabnis, Benjamin A Barad, Victor Olivas, Luping Lin, Charles H. Earnshaw, Philippe Gui, Nevan J. Krogan, Billy W. Newton, Asmin Tulpule, Manasi K. Mayekar, Elton Chan, Wei Wu, Evangelos Pazarentzos, Trever G. Bivona, Erik Verschueren, Jenny Jiacheng Yan, James S. Fraser, Saurabh Asthana, David V. Allegakoen, Nilanjana Chatterjee, John Von Dollen, William A. Weiss, Junji Suzuki, Gorjan Hrustanovic, Jeffrey R. Johnson, Jennifer Flanagan
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2317-2330.e8 (2019)
Cell reports, vol 28, iss 9
Cell reports, vol 28, iss 9
Summary: Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinase1 (PDHK1) is a synthetic-essential gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79e374b70d7e1cfafcce37c90064549
http://www.sciencedirect.com/science/article/pii/S2211124719309672
http://www.sciencedirect.com/science/article/pii/S2211124719309672
Autor:
Billy W. Newton, Michelle Trester-Zedlitz, Mark von Zastrow, Grace E. Peng, Nikoleta G. Tsvetanova, Jeffrey R. Johnson, Nevan J. Krogan, Andrew P. Kurland, David Jimenez-Morales
Publikováno v:
The Journal of Biological Chemistry
Endosomal signaling downstream of G-protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. However, our knowledge of the functional consequences of intracellular signaling is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712684f871ff48f7eba6676f979b6239
http://europepmc.org/articles/PMC8294583
http://europepmc.org/articles/PMC8294583