Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Billy Tsai"'
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114619- (2024)
Summary: Autophagosome formation initiated on the endoplasmic reticulum (ER)-associated omegasome requires LC3. Translational regulation of LC3 biosynthesis is unexplored. Here we demonstrate that LC3 mRNA is recruited to omegasomes by directly bindi
Externí odkaz:
https://doaj.org/article/849a6267d168498c9640001419faf8ca
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012289 (2024)
During entry, human papillomavirus (HPV) traffics from the endosome to the trans Golgi network (TGN) and Golgi and then the nucleus to cause infection. Although dynein is thought to play a role in HPV infection, how this host motor recruits the virus
Externí odkaz:
https://doaj.org/article/0cfc2e776dd045388ffe30dc75878d57
Autor:
Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Allen H. Hunter, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the maintenance of ER homeostasis, yet how they are integrated to regulate ER homeostasis and
Externí odkaz:
https://doaj.org/article/7ed998726ce243deacfc094c1e0fad48
Autor:
Madison L Pletan, Billy Tsai
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010948 (2022)
Host cell membranes pose a particular challenge for non-enveloped viruses. Whereas enveloped viruses enter cells by fusing their lipid envelopes with the cellular membrane, non-enveloped viruses generally must (1) enter cells via endocytosis, then (2
Externí odkaz:
https://doaj.org/article/b4dc4b409025441b91a9fd2646c9793e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Degradation of misfolded proteins from the endoplasmic reticulum (ER) is important for maintaining proper cellular protein homeostasis. Here, the authors discovered that the ER membrane protein PGRMC1 binds to misfolded prohormones for recruitment in
Externí odkaz:
https://doaj.org/article/5cc8072cd71947c2ab1c7a0a4630f5fb
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010824 (2022)
Nuclear entry represents the final and decisive infection step for most DNA viruses, although how this is accomplished by some viruses is unclear. Polyomavirus SV40 transports from the cell surface through the endosome, the endoplasmic reticulum, and
Externí odkaz:
https://doaj.org/article/a2571701e3284ca3bb7e9bd73be67df3
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010717 (2022)
Dengue virus (DENV) represents the most common human arboviral infection, yet its cellular entry mechanism remains unclear. The multi-subunit endoplasmic reticulum membrane complex (EMC) supports DENV infection, in part, by assisting the biosynthesis
Externí odkaz:
https://doaj.org/article/48bd62ed7e9445939465e554956a375a
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The endoplasmic reticulum membrane protein complex (EMC) is known to play a role in SV40 viral infection but precise mechanisms are unclear. Here, the authors report that the EMC acts as tether of late endosome–endoplasmic reticulum interorganellar
Externí odkaz:
https://doaj.org/article/65f39b7ff7a54d2399d6e7184374128b
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008946 (2020)
During internalization and trafficking, human papillomavirus (HPV) moves from the cell surface to the endosome where the transmembrane protease γ-secretase promotes insertion of the viral L2 capsid protein into the endosome membrane. Protrusion of L
Externí odkaz:
https://doaj.org/article/cb5e683e26f2456a95b50f81d48c1a17
Publikováno v:
Viruses, Vol 13, Iss 6, p 958 (2021)
To initiate infection, a virus enters a host cell typically via receptor-dependent endocytosis. It then penetrates a subcellular membrane, reaching a destination that supports transcription, translation, and replication of the viral genome. These ste
Externí odkaz:
https://doaj.org/article/685667e6ec8d4862b0eb07f56a89a4f6