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pro vyhledávání: '"Billy Li"'
Akademický článek
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Autor:
Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, Tao Sun, Gokul Ramaswami, Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
Publikováno v:
Nature
A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2133daa32404237ba4de0cbbbe42bfa
https://doi.org/10.1038/s41586-022-05052-x
https://doi.org/10.1038/s41586-022-05052-x
Akademický článek
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Autor:
Philipp Reautschnig, Nicolai Wahn, Jacqueline Wettengel, Annika E. Schulz, Ngadhnjim Latifi, Paul Vogel, Tae-Won Kang, Laura S. Pfeiffer, Christine Zarges, Ulrike Naumann, Lars Zender, Jin Billy Li, Thorsten Stafforst
Publikováno v:
Nature Biotechnology. 40:759-768
RNA base editing represents a promising alternative to genome editing. Recent approaches harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA (ADAR) to circumvent problems caused by ectopic expression of engineered editing enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fccc722c72bc8f732617b21e535164a
https://doi.org/10.1038/s41587-021-01105-0
https://doi.org/10.1038/s41587-021-01105-0
Autor:
Shi-Bin Hu, Jacki Heraud-Farlow, Tao Sun, Zhen Liang, Ankita Goradia, Scott Taylor, Carl R Walkley, Jin Billy Li
Publikováno v:
bioRxiv
SummaryEffective immunity requires the innate immune system to distinguish foreign (non-self) nucleic acids from cellular (self) nucleic acids. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA editing enzyme ADAR1 to prevent their dsRNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a473c78b5117f8d848866cc5c040021f
https://europepmc.org/articles/PMC9900771/
https://europepmc.org/articles/PMC9900771/
Autor:
Dongdong Li, Jin Billy Li, Qiangfeng Cliff Zhang, Peishan Yi, Zhiwen Zhu, Guangshuo Ou, Yufan Liu, Wei Li
Publikováno v:
Science. 373:984-991
Protein kinase activity must be precisely regulated, but how a cell governs hyperactive kinases remains unclear. In this study, we generated a constitutively active mitogen-activated protein kinase DYF-5 (DYF-5CA) in Caenorhabditis elegans that disru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e56ac51625091c4c7bf3885eae6d939
https://doi.org/10.1126/science.abd8971
https://doi.org/10.1126/science.abd8971
Autor:
Tao Sun, Qin Li, Jonathan M. Geisinger, Shi-Bin Hu, Boming Fan, Shichen Su, Waitang Tsui, Hongchao Guo, Jinbiao Ma, Jin Billy Li
The innate immune system detects viral infection via pattern recognition receptors and induces defense reactions such as production of type I interferon1. One such receptor, MDA5, is activated upon the recognition of double-stranded RNAs (dsRNAs) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6143fee41b8976551d3f9702b1e83c65
https://doi.org/10.1101/2022.08.29.505707
https://doi.org/10.1101/2022.08.29.505707
Autor:
Cameron W. Berry, Gonzalo H. Olivares, Lorenzo Gallicchio, Gokul Ramaswami, Alvaro Glavic, Patricio Olguín, Jin Billy Li, Margaret T. Fuller
Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of the 3’ cleavage site, resulting in the production of mRNA isoforms with different length 3’UTRs. Although widespread, the role of APA in the biology of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8069fcc2b308f9221cbf9db6072787
https://doi.org/10.1101/2022.05.09.489277
https://doi.org/10.1101/2022.05.09.489277
Autor:
Julia Z. Adamska, Rohit Verma, Shakti Gupta, Thomas Hagan, Florian Wimmers, Katharine Floyd, Qin Li, Erika V. Valore, Yanli Wang, Meera Trisal, José G. Vilches-Moure, Shankar Subramaniam, Carl R. Walkley, Mehul S. Suthar, Jin Billy Li, Bali Pulendran
Publikováno v:
Cell Reports. 42:112038
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1273530aa8c3c443dbfe50e3a038ddc5
https://doi.org/10.1016/j.celrep.2023.112038
https://doi.org/10.1016/j.celrep.2023.112038
Autor:
Andreas Blaha, Tobias Merkle, Qin Li, Philipp Reautschnig, Jacqueline Wettengel, Thorsten Stafforst, Paul Vogel, Jin Billy Li, Sarah Merz
Publikováno v:
Nature Biotechnology. 37:133-138
Site-directed RNA editing might provide a safer or more effective alternative to genome editing in certain clinical scenarios. Until now, RNA editing has relied on overexpression of exogenous RNA editing enzymes or of endogenous human ADAR (adenosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45a1f75874a15ad1f6f5673bee7c1ebd
https://doi.org/10.1038/s41587-019-0013-6
https://doi.org/10.1038/s41587-019-0013-6