Zobrazeno 1 - 10
of 379
pro vyhledávání: '"Billy Li"'
Autor:
Karthika Devi Kiran Kumar, Shubhangi Singh, Stella Maria Schmelzle, Paul Vogel, Carolin Fruhner, Alfred Hanswillemenke, Adrian Brun, Jacqueline Wettengel, Yvonne Füll, Lukas Funk, Valentin Mast, J. Josephine Botsch, Philipp Reautschnig, Jin Billy Li, Thorsten Stafforst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract RNA base editing relies on the introduction of adenosine-to-inosine changes into target RNAs in a highly programmable manner in order to repair disease-causing mutations. Here, we propose that RNA base editing could be broadly applied to per
Externí odkaz:
https://doaj.org/article/724df14e1cb54fe4a6a260b6d4615676
Autor:
Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Kundaje, Jin Billy Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.
Externí odkaz:
https://doaj.org/article/f291ffe598744dbb9b94da4931988805
Akademický článek
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Autor:
Patricia Deng, Anzer Khan, Dionna Jacobson, Nagraj Sambrani, Leeanne McGurk, Xianghua Li, Aswathy Jayasree, Jan Hejatko, Galit Shohat-Ophir, Mary A. O’Connell, Jin Billy Li, Liam P. Keegan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalia
Externí odkaz:
https://doaj.org/article/f2300f5bbdf84bf08236658c6672b294
Autor:
Anne L. Sapiro, Emily C. Freund, Lucas Restrepo, Huan-Huan Qiao, Amruta Bhate, Qin Li, Jian-Quan Ni, Timothy J. Mosca, Jin Billy Li
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in v
Externí odkaz:
https://doaj.org/article/1304ec9120344a938b611d234f8a9fe4
Autor:
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, III, Jin Billy Li
Publikováno v:
Cell Reports, Vol 31, Iss 7, Pp - (2020)
Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified. We perform BioID fol
Externí odkaz:
https://doaj.org/article/98102441b2a9423aa344b1d3f8811bfe
Autor:
Arielle L. Yablonovitch, Jeremy Fu, Kexin Li, Simpla Mahato, Lin Kang, Eugenia Rashkovetsky, Abraham B. Korol, Hua Tang, Pawel Michalak, Andrew C. Zelhof, Eviatar Nevo, Jin Billy Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Environmental adaptation is generally studied at the genomic level, but it may also be driven by transcriptional processes. Here, the authors investigate variation in gene expression and RNA editing across diverging populations of Drosophila melanoga
Externí odkaz:
https://doaj.org/article/62cead52afb44cf386776b39faa9d96a
Autor:
Carl R. Walkley, Jin Billy Li
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majo
Externí odkaz:
https://doaj.org/article/54e68c41a7ce4f1c94ae9b58ff342b09
Autor:
Jacki E. Heraud-Farlow, Alistair M. Chalk, Sandra E. Linder, Qin Li, Scott Taylor, Joshua M. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, Jin Billy Li, Carl R. Walkley
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing ca
Externí odkaz:
https://doaj.org/article/c8c14efd081c4bc3becd713fa259d069
Autor:
Jennifer H. Lumb, Qin Li, Lauren M. Popov, Siyuan Ding, Marie T. Keith, Bryan D. Merrill, Harry B. Greenberg, Jin Billy Li, Jan E. Carette
Publikováno v:
Cell Reports, Vol 20, Iss 4, Pp 819-831 (2017)
The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; howe
Externí odkaz:
https://doaj.org/article/365eb4a5ed964921a8174395e38e95a5