Výsledky vyhledávání - "Billy Abungu"

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

Autor: Rena Feinman, Billy Abungu, Iriana Colorado, Kolenkode B. Kannan, Edwin A. Deitch, Gregg L. Semenza, Anthony C. Watkins, Xiaofa Qin, Qi Lu, Diego Reino, David Palange, Da-Zhong Xu, Francis J. Caputo

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 300:G853-G861

Gut injury and loss of normal intestinal barrier function are key elements in the paradigm of gut-origin systemic inflammatory response syndrome, acute lung injury, and multiple organ dysfunction syndrome (MODS). As hypoxia-inducible factor (HIF-1) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e281074ce75f73426dc6bee2c83caa76
https://doi.org/10.1152/ajpgi.00459.2010

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HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury

Autor: Qi Lu, Iriana Colorado, Marta Bosch-Marce, Kolenkode B. Kannan, Madhuri Ramanathan, Sharvil U. Sheth, Rena Feinman, Francis J. Caputo, Edwin A. Deitch, Chirag D. Badami, Gregg L. Semenza, Billy Abungu, Anthony C. Watkins, Danielle Doucet, Da Zhong Xu, Dimitrios Barlos, Shirhan Attan

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G833-G843

Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) are major causes of death in trauma patients. Gut inflammation and loss of gut barrier function as a consequence of splanchnic ischemia-reperfusion (I/R) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90df5e3ccbc0653b91bc5ffbbc4cc65
https://doi.org/10.1152/ajpgi.00065.2010

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Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways

Autor: Da-Zhong Xu, Qi Lu, Iriana Colorado, Billy Abungu, Rena Feinman, Dimitrios Barlos, Edwin A. Deitch, Anthony C. Watkins, Frank J. Caputo

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 296:L404-L417

Intestinal ischemia after trauma-hemorrhagic shock (T/HS) results in gut barrier dysfunction and the production/release of biologically active and tissue injurious factors in the mesenteric lymph, which, in turn, causes acute lung injury and a system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68f1521e750b435a18cf39dfb2697c2
https://doi.org/10.1152/ajplung.00491.2007

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MOLECULAR SIGNATURES OF TRAUMA-HEMORRHAGIC SHOCK-INDUCED LUNG INJURY

Autor: Patricia Soteropoulos, Da-Zhong Xu, James Dermody, Iriana Colorado, Francis J. Caputo, Rena Feinman, Qi Lu, Hung B. Chu, Billy Abungu, Deanna Streck, Virginie Aris, Anthony Galante, Edwin A. Deitch

Publikováno v: Shock. 28:360-368

The etiology of trauma-hemorrhagic shock (T/HS)-induced acute lung injury has been difficult to elucidate because of, at least in part, the inability of in vivo studies to separate the noninjurious pulmonary effects of trauma-hemorrhage from the tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceefa451f587b6b6cb9e0dcde6074524
https://doi.org/10.1097/shk.0b013e318048565b

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PERSISTENT HIF-1?? ACTIVATION IN GUT ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BACTERIA AND LIPOPOLYSACCHARIDE

Autor: Pranoti Gangurde, Qi Lu, Hiroshi Homma, Billy Abungu, Jadd Koury, Edwin A. Deitch, Rena Feinman, Da-Zhong Xu, Michael R. Condon

Publikováno v: Shock. 22:270-277

In both animal models of hemorrhagic shock and clinical settings, shock-induced gut ischemia has been implicated in the development of the systemic inflammatory response syndrome and distant organ injury, yet the factors transducing these events rema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f610401d2db7decb360df56e1ead8
https://doi.org/10.1097/01.shk.0000135256.67441.3f

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Trauma-Hemorrhagic Shock Mesenteric Lymph Induces Endothelial Apoptosis That Involves Both Caspase-Dependent and Caspase-Independent Mechanisms

Autor: Sergey B. Zaets, György Haskó, Edwin A. Deitch, Qi Lu, Lawrence D. Gaspers, Billy Abungu, Da Zhong Xu, Marson T. Davidson, Andrew P. Thomas, Zoltán Németh

Publikováno v: Annals of Surgery. 240:123-131

To determine the mechanism by which gut-derived factors present in mesenteric lymph from rats subjected to trauma-hemorrhagic shock (T/HS) induce endothelial cell death.Intestinal ischemia after hemorrhagic shock results in gut barrier dysfunction an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bd8bfc8ecf8f3430ef710dee42db2a
https://doi.org/10.1097/01.sla.0000129341.94219.cf

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Intravenous injection of trauma-hemorrhagic shock mesenteric lymph causes lung injury that is dependent upon activation of the inducible nitric oxide synthase pathway

Autor: Frank J. Caputo, Dimitrios Barlos, Qi Lu, Maheswari Senthil, Da-Zhong Xu, Rena Feinman, Anthony C. Watkins, Edwin A. Deitch, Billy Abungu

Publikováno v: Annals of surgery. 246(5)

Objective: To test the hypothesis that gut-derived factors carried in trauma-hemorrhagic shock (T/HS) lymph is sufficient to induce lung injury. Additionally, because our previous studies showed that T/HS-induced nitric oxide production was associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b3f1a06220a0163e9e89616e10b694
https://pubmed.ncbi.nlm.nih.gov/17968175

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