Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Billur Akkaya"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/5ca41dd748354a0ca38b60a870ba493d
Autor:
Munir Akkaya, Jafar Al Souz, Daniel Williams, Rahul Kamdar, Olena Kamenyeva, Juraj Kabat, Ethan Shevach, Billur Akkaya
Publikováno v:
eLife, Vol 12 (2024)
Delineating the complex network of interactions between antigen-specific T cells and antigen presenting cells (APCs) is crucial for effective precision therapies against cancer, chronic infections, and autoimmunity. However, the existing arsenal for
Externí odkaz:
https://doaj.org/article/fa37a84c2daa401bbccbb746c12a3d89
Autor:
Bayley R. McRitchie, Billur Akkaya
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The concept of cancer immunotherapy has gained immense momentum over the recent years. The advancements in checkpoint blockade have led to a notable progress in treating a plethora of cancer types. However, these approaches also appear to have stalle
Externí odkaz:
https://doaj.org/article/8963391271814ea6bada47a0d80ee9cf
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63325 (2013)
The CD200 receptor (CD200R) is present mainly on myeloid cells and gives inhibitory signals when engaged by its ligand CD200. The interaction is currently of therapeutic interest in cancer and inflammation. However functional effects are complicated
Externí odkaz:
https://doaj.org/article/39ba6a0b6a6e4864a9b77dc5dab686b7
Autor:
Deborah D. Glass, Ryutaro Matsumura, Munir Akkaya, Ethan M. Shevach, David W. Dorward, Jafar Al Souz, Billur Akkaya, Yoshihiro Oya, Amanda H. Holstein, Juraj Kabat, Olena Kamenyeva
Publikováno v:
Nature immunology
Regulatory T cells (Treg cells) can activate multiple suppressive mechanisms in vitro after activation via the T cell antigen receptor, resulting in antigen-independent suppression. However, it remains unclear whether similar pathways operate in vivo
Autor:
Billur Akkaya, Pietro Miozzo, Susan K. Pierce, Alexander S. Roesler, Juraj Kabat, Michael N. Sack, Munir Akkaya, Margery G. Smelkinson, Jafar Al Souz, Javier Traba, Joseph Brzostowski, David W. Dorward, Mirna Pena, Brandon P. Theall
Publikováno v:
The Journal of Immunology. 201:3294-3306
Activation of CD4+ T cells to proliferate drives cells toward aerobic glycolysis for energy production while using mitochondria primarily for macromolecular synthesis. In addition, the mitochondria of activated T cells increase production of reactive
Publikováno v:
Confocal Microscopy ISBN: 9781071614013
Methods Mol Biol
Methods Mol Biol
Multiphoton microscopy has provided us the ability to visualize cell behavior and biology in intact organs due to its superiority in reaching deep into tissues. Because skin draining lymph nodes are readily accessible via minimal surgery, it is possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2530752656a3232cbd54f8868344cce7
https://doi.org/10.1007/978-1-0716-1402-0_13
https://doi.org/10.1007/978-1-0716-1402-0_13
Autor:
Ethan M. Shevach, Billur Akkaya
Publikováno v:
Cell Immunol
Treg cells are the immune system's in-house combatants against pathological immune activation. Because they are vital to maintenance of peripheral tolerance, it is important to understand how they perform their functions. To this end, various mechani
Autor:
Haewon Sohn, Jeff Skinner, Brandon P. Theall, Mirna Pena, Alexander S. Roesler, Juraj Kabat, Pietro Miozzo, Susan K. Pierce, Jinghua Lu, Ann S. Kim, David W. Dorward, Billur Akkaya, Eric Dahlstrom, Louis H. Miller, Munir Akkaya, Travis Henke
Publikováno v:
Nature immunology
Key events in T cell–dependent antibody responses, including affinity maturation, are dependent on the B cell’s presentation of antigen to helper T cells at critical checkpoints in germinal-center formation in secondary lymphoid organs. Here we f
Autor:
Mirna Pena, Susan K. Pierce, Pietro Miozzo, Billur Akkaya, Akanksha Chaturvedi, Olena Kamenyeva, Juraj Kabat, Patrick W. Sheehan, Munir Akkaya, Mukul Rawat, Ann S. Kim, Silvia Bolland
Publikováno v:
The Journal of Immunology. 199:931-940
B cells express the innate receptor, TLR9, which signals in response to unmethylated CpG sequences in microbial DNA. Of the two major classes of CpG-containing oligonucleotides, CpG-A appears restricted to inducing type 1 IFN in innate immune cells a