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Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae

Autor: Pamela A. Silver, Billie Egan, Traude H. Beilharz, Trevor Lithgow, Kay Hofmann

Publikováno v: Monash University

Tail-anchored proteins have an NH(2)-terminal cytosolic domain anchored to intracellular membranes by a single, COOH-terminal, transmembrane segment. Sequence analysis identified 55 tail-anchored proteins in Saccharomyces cerevisiae, with several nov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7dd7447fa32408c9f85f9447d1233f
https://pubmed.ncbi.nlm.nih.gov/12514182

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Targeting of tail-anchored proteins to yeast mitochondria in vivo

Autor: Sandra Isenmann, Traude H. Beilharz, Rebecca George, Sabine Gratzer, Trevor Lithgow, Binks W. Wattenberg, Billie Egan

Publikováno v: FEBS letters. 451(3)

Tail-anchored proteins are inserted into intracellular membranes via a C-terminal transmembrane domain. The topology of the protein is such that insertion must occur post-translationally, since the insertion sequence is not available for membrane ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a858a38251cda3adba78b9f44a72063
https://pubmed.ncbi.nlm.nih.gov/10371198

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Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins

Autor: Billie Egan, Kip Gabriel, Trevor Lithgow

Publikováno v: Monash University

The Translocase of the Outer Mitochondrial membrane (TOM complex) is centred on a channel, created by Tom40, serving as the only means of entry for proteins into the mitochondrion. Proteins destined for internal mitochondrial compartments interact su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b6b45e3c76771b3ee9877aac4cbd38
https://research.monash.edu/en/publications/453931c3-0e40-4347-9334-e982467c89c1

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A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase

Autor: Trevor Lithgow, Renae Allen, Traude H. Beilharz, Billie Egan, Kip Gabriel

Publikováno v: Monash University

The TOM translocase consists of several integral membrane proteins organised around the channel forming protein Tom40. Here we show that one of these protein subunits, Tom7, is a tail-anchored protein. The carboxy-terminal 33 amino acids of Tom7 cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd571764f633abdff20eb31ecf3eeed
https://research.monash.edu/en/publications/8dc8f3a7-e9c4-4c25-b045-4c8f1db6cefb

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