Protection of beta cells against cytokine-induced apoptosis by the gut microbial metabolite butyrate.

Autor: Jørgensen KS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Pedersen SS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Hjorth SA; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Billestrup N; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Prause M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Publikováno v: The FEBS journal [FEBS J] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

Autor: Urizar, A.I., Prause, M., Ingerslev, L.R., Wortham, M., Sui, Y., Sander, M., Williams, K., Barrès, R., Larsen, M.R., Christensen, G.L., Billestrup, N.

Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Lan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::ab3ff3721ebeea2897e5061785c45f81
http://edoc.mdc-berlin.de/23578/1/23578oa.pdf

Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding.

Autor: Urizar AI; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Prause M; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Ingerslev LR; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Wortham M; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, 92093, USA., Sui Y; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, 92093, USA., Sander M; Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, 92093, USA., Williams K; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Barrès R; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; Institut de Pharmacologie Moléculaire et Cellulaire, CNRS and Université de Nice Côte d'Azur, Valbonne, France., Larsen MR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Christensen GL; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark., Billestrup N; Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark. billestrup@sund.ku.dk.

Publikováno v: Cell death & disease [Cell Death Dis] 2023 Jul 05; Vol. 14 (7), pp. 399. Date of Electronic Publication: 2023 Jul 05.

Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells.

Autor: Pedersen SS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Prause M; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Williams K; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Barrès R; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur and CNRS, Valbonne, France., Billestrup N; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: billestrup@sund.ku.dk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Sep; Vol. 298 (9), pp. 102312. Date of Electronic Publication: 2022 Jul 31.

Developmental expression of proprotein convertase 1/3 in the rat

Autor: Lee, Y.C ^*, Damholt, A.B, Billestrup, N, Kisbye, T, Galante, P, Michelsen, B, Kofod, H, Nielsen, J.H

Publikováno v: In Molecular and Cellular Endocrinology 1999 155(1):27-35