Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Bill R. Miller"'
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The COVID-19 pandemic was declared due to the spread of the novel coronavirus, SARS-CoV-2. Viral infection is caused by the interaction between the SARS-CoV-2 receptor binding domain (RBD) and the human ACE2 receptor (hACE2). Previous computational s
Externí odkaz:
https://doaj.org/article/7df89489dd91466b8fdbd9d69c2ec482
Autor:
Peter K. Windsor, Stephen P. Plassmeyer, Dominic S. Mattock, Jonathan C. Bradfield, Erika Y. Choi, Bill R. Miller, Byung Hee Han
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2888 (2021)
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation
Externí odkaz:
https://doaj.org/article/eb9bc6863eba4929b281895231d5e2e2
Publikováno v:
Developmental Dynamics. 251:1741-1753
Microtubule-associated proteins regulate the dynamics, organization, and function of microtubules, impacting a number of vital cellular processes. CRMPs have been shown to control microtubule assembly and axon outgrowth during neuronal differentiatio
Autor:
Wonjun Yim, Kathryn Takemura, Jiajing Zhou, Jingcheng Zhou, Zhicheng Jin, Raina M. Borum, Ming Xu, Yong Cheng, Tengyu He, William Penny, Bill R. Miller, Jesse V. Jokerst
Publikováno v:
ACS Nano
Photoacoustic (PA) imaging has proved versatile for many biomedical applications from drug delivery tracking to disease diagnostics and postoperative surveillance. It recently emerged as a tool for accurate and real-time heparin monitoring to avoid b
Publikováno v:
ACS Symposium Series ISBN: 9780841297432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4cd4618a0a5b5c496283bd216c4bde
https://doi.org/10.1021/bk-2022-1428.ch005
https://doi.org/10.1021/bk-2022-1428.ch005
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1003961 (2014)
During DNA replication, DNA polymerases follow an induced fit mechanism in order to rapidly distinguish between correct and incorrect dNTP substrates. The dynamics of this process are crucial to the overall effectiveness of catalysis. Although X-ray
Externí odkaz:
https://doaj.org/article/e4ac890b21c4473b81c2bcb6d807384b
Publikováno v:
Journal of Chemical Information and Modeling. 59:2423-2431
DNA polymerase I from Thermus aquaticus ( Taq DNA polymerase) is useful for polymerase chain reactions because of its exceptional thermostability; however, its activity at low temperatures can cause amplification of unintended products. Mutation of i
Autor:
Brendan Drouhard, Ho Leung Ng, Abby Held, Michelle Hu, Bryant Avila, Wenjie Lu, Bill R. Miller, Raul Leyva-Montes, Samson A. Souza
Publikováno v:
RSC Chemical Biology
Aromatase (CYP19) catalyzes the last biosynthetic step of estrogens in mammals and is a primary drug target for hormone-related breast cancer. However, treatment with aromatase inhibitors is often associated with adverse effects and drug resistance.
Autor:
Jonathan C. Bradfield, Stephen P. Plassmeyer, Erika Y. Choi, Byung Hee Han, Bill R. Miller, Dominic S. Mattock, Peter K. Windsor
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2888, p 2888 (2021)
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 2888, p 2888 (2021)
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation
Autor:
Carol A. Parish, Lauren M. McRae, Bill R. Miller, Justin Airas, Neda Ojaghlou, Cooper A. Taylor
Publikováno v:
Journal of chemical information and modeling. 61(1)
Recent experiments indicate that the C-Jun amino-terminal kinase-interacting protein 1 (JIP1) binds to and activates the c-Jun N-terminal kinase (JNK) protein. JNK is an integral part of cell apoptosis, and misregulation of this process is a causativ