Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bill Leavens"'
Autor:
Svend Kjaer, Michael J. Pattison, Yasmina Soneji, David J. Powell, Steven C. Ley, Bill Leavens, Chao-Sheng Chen, David House, Carl Haslam, Probir Chakravarty, Sandra Kümper, Thorsten Gantke, Daniel Thomas
Publikováno v:
Biochemical Journal
The MKK1/2 kinase tumour progression locus 2 (TPL-2) is critical for the production of tumour necrosis factor alpha (TNFα) in innate immune responses and a potential anti-inflammatory drug target. Several earlier pharmaceutical company screens with
Autor:
Angela Bridges, Mike Rees, Peter Francis, Argyrides Argyrou, Bill Leavens, Melanie Leveridge, Chun-wa Chung, P. Hardwicke, Andrew West, Rachel Buxton, Steven J. Ratcliffe
Publikováno v:
SLAS Discovery. 19:278-286
Using mass spectrometry to detect enzymatic activity offers several advantages over fluorescence-based methods. Automation of sample handling and analysis using platforms such as the RapidFire (Agilent Technologies, Lexington, MA) has made these assa
Autor:
Peter Francis, Bill Leavens, Michelle L. Heathcote, Melanie Leveridge, Chun-wa Chung, Paul Homes, Argyrides Argyrou, Jordi Munoz-Muriedas, Michelle Gee, Laura Williams, Stuart M. Baddeley, Sue Hutchinson, Anthony Shillings, Emma J. Jones, Angela Bridges
Publikováno v:
SLAS Discovery. 17:39-48
A high-throughput RapidFire mass spectrometry assay is described for the JMJD2 family of Fe(2+), O(2), and α-ketoglutarate-dependent histone lysine demethylases. The assay employs a short amino acid peptide substrate, corresponding to the first 15 a
Autor:
Laurie J. Gordon, Andrew West, André Mateus, Michael M. Hann, Klára Valkó, Bill Leavens, Simon A. Readshaw, Morven Allen, Per Artursson, Gareth Wayne
Publikováno v:
Journal of biomolecular screening. 21(2)
One of the key challenges facing early stage drug discovery is understanding the commonly observed difference between the activity of compounds in biochemical assays and cellular assays. Traditionally, indirect or estimated cell permeability measurem
Autor:
Phil Hardwicke, Luigi Piero Stasi, Melanie Leveridge, Alan Nadin, Alastair D. Reith, Colin M. Edge, Lee Collier, Bill Leavens, Steve Ratcliffe, Mike Rees
Publikováno v:
Journal of biomolecular screening. 21(2)
LRRK2 is a large multidomain protein containing two functional enzymatic domains: a GTPase domain and a protein kinase domain. Dominant coding mutations in the LRRK2 protein are associated with Parkinson's disease (PD). Among such pathogenic mutation
Publikováno v:
Rapid Communications in Mass Spectrometry. 16:1377-1388
A system is presented that demonstrates the principle of on-line and on-chip post-column derivatisation reactions in micro-high-performance liquid chromatography (micro-HPLC) hyphenated to electrospray time-of-flight mass spectrometry (ESI-TOFMS). In
Autor:
Bill Leavens, Jonathan P. Hutchinson, Carl Haslam, Damian J. Mole, John Liddle, Scott P. Webster, Beverley A. Yard, Argyrides Argyrou, Erica Christodoulou, Margaret Binnie, Paul Hissey, P. Hardwicke, Kris Wilson, Denise M. Lowe, Tony W. Dean, Iain Uings, Michelle Gee
Publikováno v:
Journal of biomolecular screening. 19(4)
Kynurenine 3-monooxygenase (KMO) is a therapeutically important target on the eukaryotic tryptophan catabolic pathway, where it converts L-kynurenine (Kyn) to 3-hydroxykynurenine (3-HK). We have cloned and expressed the human form of this membrane pr
Publikováno v:
Journal of chromatography. A. 1056(1-2)
Both LC and capillary LC (CapLC) have been successfully interfaced with inductively coupled plasma mass spectrometry (ICP-MS). Gradients of acetonitrile and aqueous based solvents have been employed to separate several compounds of pharmaceutical int
Publikováno v:
Micro Total Analysis Systems 2001 ISBN: 9789401038935
A micromixer chip used previously for organic reaction chemistries [1] is applied for post-column derivatisation in µ-HPLC hyphenated to a Time-of-Flight mass spectrometer (TOFMS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ca665e61ad9a8091b4d072b81611b6e
https://doi.org/10.1007/978-94-010-1015-3_96
https://doi.org/10.1007/978-94-010-1015-3_96