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Structure−Activity Relationship of (1-Aryl-2-piperazinylethyl)piperazines: Antagonists for the AGRP/Melanocortin Receptor Binding

Autor: Xiaohu Ouyang, Christopher H. Fotsch, Kevin Lee Stark, Mark H. Norman, Bill Karbon, Nuria A. Tamayo, Janet Cheetham, James W. Baumgartner, Martha Zambrano, Michael G. Kelly, Premilla Arasasingham, Clarence Hale

Publikováno v: Journal of Medicinal Chemistry. 46:9-11

Agouti-related protein (AGRP) is an endogenous antagonist of the melanocortin action.(1) In the hypothalamus, melanocortin peptide agonists act as satiety-inducing factors that mediate their action through the melanocortin-4 receptor (MC4R) whereas A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297a05d8180b0d7331be2fa82a9dd52e
https://doi.org/10.1021/jm0255522

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