Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bill J. Roberts"'
Autor:
David W. Fry, William L. Elliott, Patrick W. Vincent, Dennis J. McNamara, Jeff B. Smaill, William A. Denny, Zhou Hairong, James M. Nelson, H. D. Hollis Showalter, Veronika Sherwood, Bill J. Roberts, Alexander James Bridges
Publikováno v:
Journal of Medicinal Chemistry. 44:429-440
4-Anilinoquinazoline- and 4-anilinopyrido[3,4-d]pyrimidine-6-acrylamides are potent pan-erbB tyrosine kinase inactivators, and one example (CI-1033) is in clinical trial. A series of analogues with a variety of Michael acceptor units at the 6-positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d10c67de11114be6a17fc2c444dea44
https://doi.org/10.1021/jm000372i
https://doi.org/10.1021/jm000372i
Autor:
Wayne Klohs, Denise L. Driscoll, Aneesa M. Amar, Wilbur R. Leopold, H. D. Hollis Showalter, Brian G. Hartl, William L. Elliott, Bill J. Roberts, Stacey L. Boushelle, Andrew M. Thompson, Randall W. Steinkampf, Connolly Cleo, Patrick W. Vincent, William A. Denny, James M. Hamby, Sandra J. Patmore, Alan J. Kraker
Publikováno v:
Journal of Medicinal Chemistry. 43:4200-4211
A series of 3-aryl-1,6-naphthyridine-2,7-diamines and related 2-ureas were prepared and evaluated as inhibitors of the FGF receptor-1 tyrosine kinase. Condensation of 4,6-diaminonicotinaldehyde and substituted phenylacetonitriles gave intermediate na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07718491fc8ec80795a8cc02f1071ca
https://doi.org/10.1021/jm000161d
https://doi.org/10.1021/jm000161d
Autor:
Brian G. Hartl, Randy Steinkampf, T C Major, Joan A. Keiser, Tawny K. Dahring, H. D. Hollis Showalter, Gina H. Lu, Alan J. Kraker, Robert L. Panek, Hussein Hallak, Brian L. Batley, Zhipei Wu, Bill J. Roberts, Sylvester Klutchko, Sandra J. Patmore, William L. Elliott, Laura A. Bradford, Wayne D. Klohs, Annette Marian Doherty, James Marino Hamby, Diane H. Boschelli
Publikováno v:
Journal of Medicinal Chemistry. 41:4365-4377
Screening of a compound library led to the identification of 2-amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidine (1) as a inhibitor of the platelet-derived growth factor receptor (PDGFr), fibroblast growth factor receptor (FGFr), and c-src
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc761f1e47ac7d9db7f59488360a5bd4
https://doi.org/10.1021/jm980398y
https://doi.org/10.1021/jm980398y
Autor:
Moore Richard E, Alfred J. Lawson, Lisa Polin, Wilbur R. Leopold, Bill J. Roberts, Stuart T. Hazeldine, Jerome P. Horwitz, Juiwanna Kushner, Thomas H. Corbett, James B. Rake, Kathryn White
Publikováno v:
Tumor Models in Cancer Research ISBN: 9781607619673
As preclinical chemotherapists, we are often asked to identify experimental tumor models that can accurately predict for the drug response characteristics of all tumors of a given cellular subtype or molecular target. Unfortunately, it is impossible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1545a271a635685d78dbe5bf4e50efd5
https://doi.org/10.1007/978-1-60761-968-0_3
https://doi.org/10.1007/978-1-60761-968-0_3
Autor:
Thomas H Corbett, Lisa Polin, Bill J Roberts, Alfred J Lawson, Wilbur R Leopold, Kathryn White, Juiwanna Kushner, Jennifer Paluch, Stuart Hazeldine, Richard Moore, James Rake, Jerome P Horwitz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2876c5df954d9b5def332ba4584f5586
https://doi.org/10.1385/1-59259-100-0:041
https://doi.org/10.1385/1-59259-100-0:041
Autor:
Jeffrey Bruce Smaill, Brian D. Palmer, Alexander James Bridges, Bill J. Roberts, James M. Nelson, David W. Fry, Ellen M. Dobrusin, Gordon W. Rewcastle, R. T. Winters, W. L. Elliot, H. D. H. Showalter, S. J. Patmore, Patrick W. Vincent, William A. Denny, Zhou Hairong, W. R. Leopold, Dennis J. McNamara, V. Slintak
Publikováno v:
Journal of medicinal chemistry. 42(10)
A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR) inhibitors were prepared from the corresponding amino compounds by reaction with either acryloyl ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97436fcf0b3737c2c47c6ea5c3bc1d50
https://pubmed.ncbi.nlm.nih.gov/10346932
https://pubmed.ncbi.nlm.nih.gov/10346932
Autor:
James M. Nelson, Gordon W. Rewcastle, D. K. Murray, Patrick W. Vincent, Curtis T. Howard, H. D. H. Showalter, William A. Denny, Bill J. Roberts, William L. Elliott, R. T. Winters, David W. Fry
Publikováno v:
Journal of medicinal chemistry. 41(5)
The 4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidine PD 158780 is a very potent in vitro inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50 0.08 nM), and other members of the erbB family, by competitive bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b32f47d98b700584ad8a6f6e0f0890
https://pubmed.ncbi.nlm.nih.gov/9513602
https://pubmed.ncbi.nlm.nih.gov/9513602
Autor:
David W. Fry, Andrew M. Thompson, Patrick W. Vincent, James A. Nelson, H. D. Hollis Showalter, William L. Elliott, Donna K. Murray, William A. Denny, Bill J. Roberts
Publikováno v:
Journal of medicinal chemistry. 40(24)
The general class of 4-(phenylamino)quinazolines are potent (some members with IC50 values1 nM) and selective inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR), via competitive binding at the ATP site of the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fcf5b06ae5ffa4491f15daf3b9aa73
https://pubmed.ncbi.nlm.nih.gov/9397172
https://pubmed.ncbi.nlm.nih.gov/9397172
Autor:
William L. Elliott, Anthony D. Sercel, Alan J. Kraker, Boguslawa Leja, Charles W. Moore, David W. Fry, Andrew M. Thompson, Wolfangel Craig Daniel, Patrick W. Vincent, H. D. Hollis Showalter, Gina H. Lu, Bill J. Roberts, Curtis T. Howard, James M. Nelson, Linda A. Ambroso, William A. Denny
Publikováno v:
Journal of medicinal chemistry. 40(4)
A small series of 2,2'-diselenobis(1H-indoles) was synthesized as redox-modified congeners of our earlier reported 2,2'-dithiobis(1H-indole) series. Utilizing chemistry similar to that developed earlier for the disulfur series, compounds were made fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa169b3ed4593faa06f23a6b4977a66
https://pubmed.ncbi.nlm.nih.gov/9046331
https://pubmed.ncbi.nlm.nih.gov/9046331
Autor:
Bill J. Roberts, Charles H. Mohr
Publikováno v:
Journal of Petroleum Technology. 24:1484-1490
Down-hole motors can be used successfully in conventional or straight-hole work, and are no longer limited to directional drilling. Recent development work and field tests involving hydraulics, bit design, and stabilization have defined the condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5ca8878ef77544f955bb90c31598676
https://doi.org/10.2118/3343-pa
https://doi.org/10.2118/3343-pa