Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Bill H Diplas"'
Autor:
Kevin J. Tu, Bill H. Diplas, Joshua A. Regal, Matthew S. Waitkus, Christopher J. Pirozzi, Zachary J. Reitman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Enzymes with novel functions are needed to enable new organic synthesis techniques. Drawing inspiration from gain-of-function cancer mutations that functionally alter proteins and affect cellular metabolism, we developed METIS (Mutated Enzym
Externí odkaz:
https://doaj.org/article/94c7355530204fc0a288b6a401f0b9e5
Autor:
Cheng Xu, Heng Liu, Christopher J. Pirozzi, Lee H. Chen, Paula K. Greer, Bill H. Diplas, Liwei Zhang, Matthew S. Waitkus, Yiping He, Hai Yan
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are high-grade tumors of the brainstem that often occur in children, with a median overall survival of less than one year. Given the fact that DIPGs are resistant to chemotherapy and are not amenable
Externí odkaz:
https://doaj.org/article/e93641f3ec424b8eb9474f91fac10d50
Autor:
Lee H. Chen, Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, Yibo Geng, Tao Sun, Yu Sun, Peng Zhang, Zhen Wu, Junting Zhang, Deling Li, Yang Zhang, Wenhao Wu, Yu Wang, Guangyu Li, Jie Yang, Xiaoyue Wang, Ce Xu, Sizhen Wang, Matthew S. Waitkus, Yiping He, Roger E. McLendon, David M. Ashley, Hai Yan, Liwei Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical
Externí odkaz:
https://doaj.org/article/20c3ed793a784a5b8bd512a9238d11e8
Autor:
Kathryn Gunn, Matti Myllykoski, John Z. Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Samuel K. McBrayer, Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman
Publikováno v:
Cancer Discovery. :OF1-OF20
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17a831bbaa9e912c12db5173510ed71
https://doi.org/10.1158/2159-8290.cd-22-0825
https://doi.org/10.1158/2159-8290.cd-22-0825
Autor:
Bill H. Diplas, Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner, Yuchen Jiao, Matthew S. Waitkus, Alan K. Meeker, Hai Yan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying
Externí odkaz:
https://doaj.org/article/dd48eac540f1490a9bb31a4f740711ca
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Characterization of isogenic TF-1 cell lines expressing TET2-targeting shRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c0253e6cb822e9454849c80b13b0b9
https://doi.org/10.1158/2159-8290.22726185
https://doi.org/10.1158/2159-8290.22726185
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Supplementary Table S9 shows the gene set enrichment analysis gene set that corresponds to Figure S6A.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1c7a0c07433053d1104ba768d7d3b7
https://doi.org/10.1158/2159-8290.22726125
https://doi.org/10.1158/2159-8290.22726125
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
List of supplementary figures and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dd59e22e8ff31e5a9fd98c7e36cc5e
https://doi.org/10.1158/2159-8290.22726188.v1
https://doi.org/10.1158/2159-8290.22726188.v1
Autor:
Julie-Aurore Losman, Peppi Koivunen, Lucy A. Godley, Cihangir Duy, Hai Yan, Samuel K. McBrayer, Harley I. Kornblum, Keith L. Ligon, John G. Doench, Ryan Looper, Michael M. Levitt, Bill H. Diplas, Betty Rouaisnel, Bofu Huang, Manna Ahmed, John Z. Cao, Matti Myllykoski, Kathryn Gunn
Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate [(R)-2HG], an oncometabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b46c54a46a79fa7c618db044703ef3e
https://doi.org/10.1158/2159-8290.c.6624819.v1
https://doi.org/10.1158/2159-8290.c.6624819.v1
Autor:
Bill H, Diplas, Patricia Mae G, Santos, Armin, Shahrokni, Andrew, Warner, Puneeth, Iyengar, Jonathan T, Yang, Daniel R, Gomez, David A, Palma, C Jillian, Tsai
Publikováno v:
Seminars in Radiation Oncology. 32:135-141
For patients with oligometastatic cancer, radiotherapy presents a promising avenue for achieving meaningful symptom relief and durable disease control. Data from recently published and ongoing randomized studies are helping to define the appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393559941ef4df4f7e399ece7ff7c00a
https://doi.org/10.1016/j.semradonc.2021.11.009
https://doi.org/10.1016/j.semradonc.2021.11.009