Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Bill D. Roebuck"'
Autor:
Merricka C. Livingstone, Natalie M. Johnson, John D. Groopman, Bill D. Roebuck, Thomas W. Kensler
Publikováno v:
Mol Carcinog
Exploration of animal models leads to discoveries that can reveal candidate biomarkers for translation to human populations. Herein, a model of hepatocarcinogenesis and protection was used in which rats treated with aflatoxin (AFB1 ) daily for 28 day
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9935e104c8a28f096e8379bc02875657
https://doi.org/10.1002/mc.23093
https://doi.org/10.1002/mc.23093
Autor:
Bill D. Roebuck
Publikováno v:
Science (New York, N.Y.). 367(6478)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca356c16626414ecf12e0e27403b72e
https://pubmed.ncbi.nlm.nih.gov/32029632
https://pubmed.ncbi.nlm.nih.gov/32029632
Autor:
Bill D. Roebuck, Thomas W. Kensler, Merricka C. Livingstone, Natalie M. Johnson, John D. Groopman
Publikováno v:
Molecular Carcinogenesis. 56:2382-2390
Aflatoxin B1 (AFB1) is a potent human and animal hepatocarcinogen. To investigate the effects of aflatoxin on miRNA expression during the initiation phase of carcinogenesis, next-generation sequencing was used to analyze liver tissues from F344 rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a05acb9c0fb0edc1cda15f91e5cd8d
https://doi.org/10.1002/mc.22635
https://doi.org/10.1002/mc.22635
Autor:
Merricka C, Livingstone, Natalie M, Johnson, Bill D, Roebuck, Thomas W, Kensler, John D, Groopman
Publikováno v:
Molecular carcinogenesis. 56(11)
Aflatoxin B1 (AFB1) is a potent human and animal hepatocarcinogen. To investigate the effects of aflatoxin on miRNA expression during the initiation phase of carcinogenesis, next-generation sequencing was used to analyze liver tissues from F344 rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5fe7140436661227962bf79f215425f
https://pubmed.ncbi.nlm.nih.gov/28218475
https://pubmed.ncbi.nlm.nih.gov/28218475
Autor:
Bill D. Roebuck, Thomas W. Kensler, John D. Groopman, Merricka C. Livingstone, Natalie M. Johnson
Publikováno v:
Cancer Research. 78:5401-5401
Hepatocellular carcinoma (HCC) continues to be a major cause of cancer death globally, with aflatoxin B1 (AFB1) as a prevalent risk factor in low- and middle-income countries. MicroRNAs have been shown to be differentially expressed in HCC and may se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bab4cf6975873f2916da322bc82d762
https://doi.org/10.1158/1538-7445.am2018-5401
https://doi.org/10.1158/1538-7445.am2018-5401
Autor:
Albena T. Dinkova-Kostova, Michael B. Sporn, Hidenori Yoshizawa, Gordon W. Gribble, Chitra Sundararajan, Mark M. Yore, John D. Groopman, Melinda S. Yates, Karen J. Baumgartner, Tadashi Honda, Katherine K. Stephenson, Karen T. Liby, Charlotte R. Williams, Bill D. Roebuck, Darlene B. Royce, Patricia A. Egner, Thomas W. Kensler, Renee Risingsong
Publikováno v:
Cancer Research. 68:6727-6733
A novel acetylenic tricyclic bis-(cyano enone), TBE-31, is a lead compound in a series of tricyclic compounds with enone functionalities in rings A and C. Nanomolar concentrations of this potent multifunctional molecule suppress the induction of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5335bbad1e0982b09b3d8cde1a722ed1
https://doi.org/10.1158/0008-5472.can-08-1123
https://doi.org/10.1158/0008-5472.can-08-1123
Autor:
Laundette Knight Jones, Carrie Hayes Sutter, Thomas W. Kensler, Patricia A. Egner, Bill D. Roebuck, F. Peter Guengerich, Thomas R. Sutter, Sridevi Bodreddigari, John D. Groopman
Publikováno v:
Chemical Research in Toxicology. 21:1134-1142
The reduction of the aflatoxin B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27299cdad30708f589875c9e338016ae
https://doi.org/10.1021/tx7004458
https://doi.org/10.1021/tx7004458
Autor:
Bill D. Roebuck
Publikováno v:
Journal of Cellular Biochemistry. 91:243-249
Generalized cellular hyperplasia has long been associated as a factor in the causation of liver cancer. Parenchymal cell hyperplasia resulting from hepatotoxins, viruses, parasites, or malnutrition is exceedingly variable as to when it occurs, its ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df99b73eb1a14e7d93264d38dc0ed520
https://doi.org/10.1002/jcb.10758
https://doi.org/10.1002/jcb.10758
Autor:
Jesse K. Johnson, Thomas W. Kensler, Bill D. Roebuck, Patricia A. Egner, Christopher K. Nathasingh, John D. Groopman, Xiang Yu
Publikováno v:
Chemical Research in Toxicology. 16:1174-1180
Epidemiological studies have shown that exposure to aflatoxin B(1) (AFB(1)) and concurrent infection with hepatitis B lead to a multiplicative risk of developing liver cancer. This chemical-viral interaction can be recapitulated in the tree shrew (Tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bec76113d552f6933b3932608caeb
https://doi.org/10.1021/tx034106u
https://doi.org/10.1021/tx034106u